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Published Online June 27, 2002
Science DOI: 10.1126/science.1070850

Reports

Submitted on February 13, 2002
Accepted on June 4, 2002

Systematic Identification of Pathways That Couple Cell Growth and Division in Yeast

Paul Jorgensen 1, Joy L. Nishikawa 1, Bobby-Joe Breitkreutz 2, Mike Tyers 1*

1 Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8; Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.
2 Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.

* To whom correspondence should be addressed. E-mail: tyers{at}mshri.on.ca.

Size homeostasis in budding yeast requires that cells grow to a critical size before commitment to division in late G1 phase of the cell cycle, an event termed Start. We determined cell size distributions for the complete set of ~6,000 Saccharomyces cerevisiae gene deletion strains and identified ~500 abnormally small (whi) or large (lge) mutants. Genetic analysis revealed a complex network of new factors that govern critical cell size at Start, the most potent of which were Sfp1, Sch9, Cdh1, Prs3, and Whi5. Ribosome biogenesis is intimately linked to cell size through Sfp1, a transcription factor that controls the expression of at least 60 genes implicated in ribosome assembly. Cell growth and division appear to be coupled by multiple conserved mechanisms.


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