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Submitted on September 17, 2001
Accepted on September 17, 2001
Stress, NK Receptors and Immune Surveillance
Drew M. Pardoll 1*
1 Department of Oncology, the Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
* To whom correspondence should be addressed. E-mail: dmpardol{at}jhmi.edu.
It has long been suspected that natural killer (NK) cells are involved in immune surveillance. Now comes new work, described by Drew Pardoll in his Perspective, showing that T cells expressing an NK cell receptor called NKG2D are important for detecting precancerous skin epithelial cells in mice (Girardi et al.). Engagement of NKG2D with its ligands Rae1 or H60 expressed on mouse epidermal cells treated with carcinogens results in activation of T cells, which eliminate the precancerous epidermal cells before they become established as tumors.
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REPORTS
Michael Girardi, David E. Oppenheim, Carrie R. Steele, Julia M. Lewis, Earl Glusac, Renata Filler, Paul Hobby, Brian Sutton, Robert E. Tigelaar, and Adrian C. Hayday (19 October 2001) Science294 (5542), 605.
[DOI: 10.1126/science.1063916] |Abstract »|Full Text »|PDF »|Supplemental Data »
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