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Published Online September 27, 2001
Science DOI: 10.1126/science.1066282

Perspectives

Submitted on September 17, 2001
Accepted on September 26, 2001

Endothelium--Chicken Soup for the Endoderm

Nathan Bahary 1 Leonard I. Zon 2*

1 Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
2 Department of Hematology/Oncology, Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.

* To whom correspondence should be addressed. E-mail: zon{at}genetics.med.harvard.edu.

Endothelial cells in blood vessels are known to be important during the later stages of organ development in the embryo. However, their involvement at the induction stage of organ formation has not been previously documented. As Bahary and Zon explain in their Perspective, new work demonstrates that endothelial cells secrete factors early in development that induce embryonic endoderm to become liver or pancreas (Matsumoto et al., Lammert et al.).


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