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Published Online September 27, 2001
Science DOI: 10.1126/science.1064344

Research Articles

Submitted on July 12, 2001
Accepted on September 12, 2001

Induction of Pancreatic Differentiation by Signals from Blood Vessels

Eckhard Lammert 1, Ondine Cleaver 1, Douglas Melton 1*

1 Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.

Blood vessels supply developing organs with metabolic sustenance. Here we demonstrate a role for blood vessels as a source of developmental signals during pancreatic organogenesis. In vitro experiments with embryonic mouse tissues demonstrate that blood vessel endothelium induces insulin expression in isolated endoderm. Removal of the dorsal aorta in Xenopus embryos results in the failure of insulin expression in vivo. Furthermore, using transgenic mice, we show that ectopic vascularization in the posterior foregut leads to ectopic insulin expression and islet hyperplasia. These results indicate that vessels not only provide metabolic sustenance but also provide inductive signals for organ development.


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J. Histochem. Cytochem. 51, 697-706
   Abstract »    Full Text »    PDF »
Human embryonic stem cells for cardiovascular repair.
S. G. Nir, R. David, M. Zaruba, W.-M. Franz, and J. Itskovitz-Eldor (2003)
Cardiovasc Res 58, 313-323
   Abstract »    Full Text »    PDF »
Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad.
J. Brennan, C. Tilmann, and B. Capel (2003)
Genes & Dev. 17, 800-810
   Abstract »    Full Text »    PDF »
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors.
G. Gu, J. Dubauskaite, and D. A. Melton (2003)
Development 129, 2447-2457
   Abstract »    Full Text »    PDF »
Modulation of VEGFR-2-mediated endothelial-cell activity by VEGF-C/VEGFR-3.
K. Matsumura, M. Hirashima, M. Ogawa, H. Kubo, H. Hisatsune, N. Kondo, S. Nishikawa, T. Chiba, and S.-I. Nishikawa (2003)
Blood 101, 1367-1374
   Abstract »    Full Text »    PDF »


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