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Published Online September 20, 2001
Science DOI: 10.1126/science.1064252

Research Articles

Submitted on July 10, 2001
Accepted on September 10, 2001

Patterning of the Neocortex by the Secreted Signaling Molecule FGF8

Tomomi Fukuchi-Shimogori 1 Elizabeth A. Grove 1*

1 Department of Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, IL 60637, USA.

A classic model proposes that mammalian neocortex is divided into areas early in neurogenesis, but the molecular mechanisms that generate the area map have been elusive. Here we provide evidence that FGF8 regulates development of the map from a source in the anterior telencephalon. Using electroporation-mediated gene transfer in mouse embryos we show that augmenting the endogenous anterior FGF8 signal shifts area boundaries posteriorly, reducing the signal shifts them anteriorly, and introducing a posterior source of FGF8 elicits partial area duplications, revealed by ectopic somatosensory barrel fields. These findings support a role for FGF signaling in specifying positional identity in the neocortex.


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