Chronobiology: Reducing Time

doi:10.1126/science.1063296

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Published Online July 5, 2001
Science DOI: 10.1126/science.1063296

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Submitted on June 26, 2001
Accepted on June 26, 2001

Chronobiology: Reducing Time

Ueli Schibler ¹^*, Juergen A. Ripperger ¹, Steven A. Brown ¹

¹ Department of Molecular Biology, Sciences II, University of Geneva, CH-1211 Geneva-4, Switzerland.

^* To whom correspondence should be addressed. E-mail: Ueli.Schibler{at}molbio.unige.ch.

The physiology and behavior of mammals are subject to daily oscillations. These oscillations are driven by a master clock in the suprachiasmatic nucleus (SCN) of the brain's hypothalamus and by clocks in most other cell types that contain many of the same protein components. But what regulates the activity of these clocks? The answer, according to Schibler, Ripperger and Brown reporting in their Perspective on new work from Steve McKnight's group, may lie in cellular metabolism. It turns out that two crucial clock proteins (transcription factors that switch on target genes involved in circadian oscillations) are regulated in vitro by the ratio between reduced and oxidized forms of the respiratory chain electron carrier NAD that fluctuate according to the metabolic state of the cell.

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REPORTS Regulation of Clock and NPAS2 DNA Binding by the Redox State of NAD Cofactors: Jared Rutter, Martin Reick, Leeju C. Wu, and Steven L. McKnight (20 July 2001)
Science 293 (5529), 510. [DOI: 10.1126/science.1060698]
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REPORTS NPAS2: An Analog of Clock Operative in the Mammalian Forebrain: Martin Reick, Joseph A. Garcia, Carol Dudley, and Steven L. McKnight (20 July 2001)
Science 293 (5529), 506. [DOI: 10.1126/science.1060699]
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