Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Published Online July 23, 2001
Science DOI: 10.1126/science.1060638

Reports

Submitted on March 12, 2001
Accepted on June 5, 2001

Modeling Household Transmission of American Trypanosomiasis

Joel E. Cohen 1* Ricardo E. Gürtler 2

1 Laboratory of Populations, Rockefeller University and Columbia University, 1230 York Avenue, Box 20, New York, NY 10021,USA.
2 Laboratorio de Ecologia General, Faculatad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina.

* To whom correspondence should be addressed. E-mail: cohen{at}rockefeller.edu.

American trypanosomiasis, or Chagas disease, caused by the protozoan parasite Trypanosoma cruzi and transmitted by blood-feeding triatomine bugs, is a chronic, frequently fatal infection that is common in Latin America. Neither adequate drugs nor a vaccine is available. A mathematical model calibrated to detailed household data from three villages in northwest Argentina shows that householders could greatly reduce the risk of human infection by excluding domestic animals, especially infected dogs, from bedrooms; removing potential refuges for bugs from walls and ceilings; and using domestically applied insecticides. Low-cost, locally practicable environmental management combined with intermittent use of insecticides can sustainably control transmission of T. cruzi to humans in rural Argentina and probably elsewhere.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neglected tropical diseases.
N. Feasey, M. Wansbrough-Jones, D. C. W. Mabey, and A. W. Solomon (2009)
Br. Med. Bull.
   Abstract »    Full Text »    PDF »
Impregnated Netting Slows Infestation by Triatoma infestans.
M. Z. Levy, V. R. Quispe-Machaca, J. L. Ylla-Velasquez, L. A. Waller, J. M. Richards, B. Rath, K. Borrini-Mayori, J. G. C. del Carpio, E. Cordova-Benzaquen, F. E. McKenzie, et al. (2008)
Am J Trop Med Hyg 79, 528-534
   Abstract »    Full Text »    PDF »
Cost-effectiveness of Implementation Methods for ELISA Serology Testing of Trypanosoma cruzi in California Blood Banks.
L. S. Wilson, J. M. Ramsey, Y. B. Koplowicz, L. Valiente-Banuet, C. Motter, S. M. Bertozzi, and L. H. Tobler (2008)
Am J Trop Med Hyg 79, 53-68
   Abstract »    Full Text »    PDF »
Demographic and Dispersal Constraints for Domestic Infestation by Non-Domicilated Chagas Disease Vectors in the Yucatan Peninsula, Mexico.
S. Gourbiere, E. Dumonteil, J. E. Rabinovich, R. Minkoue, and F. Menu (2008)
Am J Trop Med Hyg 78, 133-139
   Abstract »    Full Text »    PDF »
Sustainable vector control and management of Chagas disease in the Gran Chaco, Argentina.
R. E. Gurtler, U. Kitron, M. C. Cecere, E. L. Segura, and J. E. Cohen (2007)
PNAS 104, 16194-16199
   Abstract »    Full Text »    PDF »
Chagas disease.
A R L Teixeira, N Nitz, M C Guimaro, C Gomes, and C A Santos-Buch (2006)
Postgrad. Med. J. 82, 788-798
   Abstract »    Full Text »    PDF »
A PROSPECTIVE STUDY OF THE EFFECTS OF SUSTAINED VECTOR SURVEILLANCE FOLLOWING COMMUNITY-WIDE INSECTICIDE APPLICATION ON TRYPANOSOMA CRUZI INFECTION OF DOGS AND CATS IN RURAL NORTHWESTERN ARGENTINA..
M. V. CARDINAL, M. B. CASTANERA, M. A. LAURICELLA, M. C. CECERE, L. A. CEBALLOS, G. M. VAZQUEZ-PROKOPEC, U. KITRON, and R. E. GURTLER (2006)
Am J Trop Med Hyg 75, 753-761
   Abstract »    Full Text »    PDF »
Host heterogeneity dominates West Nile virus transmission.
A Marm Kilpatrick, P. Daszak, M. J Jones, P. P Marra, and L. D Kramer (2006)
Proc R Soc B 273, 2327-2333
   Abstract »    Full Text »    PDF »
EXTINCTION OF EXPERIMENTAL TRIATOMA INFESTANS POPULATIONS FOLLOWING CONTINUOUS EXPOSURE TO DOGS WEARING DELTAMETHRIN-TREATED COLLARS..
R. REITHINGER, L. CEBALLOS, R. STARIOLO, C. R. DAVIES, and R. E. GURTLER (2006)
Am J Trop Med Hyg 74, 766-771
   Abstract »    Full Text »    PDF »
INCIDENCE OF TRYPANOSOMA CRUZI INFECTION AMONG CHILDREN FOLLOWING DOMESTIC REINFESTATION AFTER INSECTICIDE SPRAYING IN RURAL NORTHWESTERN ARGENTINA.
R. E. GURTLER, M. C. CECERE, M. A. LAURICELLA, R. M. PETERSEN, R. CHUIT, E. L. SEGURA, and J. E. COHEN (2005)
Am J Trop Med Hyg 73, 95-103
   Abstract »    Full Text »    PDF »
SPATIO-TEMPORAL ANALYSIS OF REINFESTATION BY TRIATOMA INFESTANS (HEMIPTERA: REDUVIIDAE) FOLLOWING INSECTICIDE SPRAYING IN A RURAL COMMUNITY IN NORTHWESTERN ARGENTINA.
M. C. CECERE, G. M. VAZQUEZ-PROKOPEC, R. E. GURTLER, and U. KITRON (2004)
Am J Trop Med Hyg 71, 803-810
   Abstract »    Full Text »    PDF »
CHAGAS DISEASE IN RURAL AREAS OF CHACO PROVINCE, ARGENTINA: EPIDEMIOLOGIC SURVEY IN HUMANS, RESERVOIRS, AND VECTORS.
P. DIOSQUE, A. M. PADILLA, R. O. CIMINO, R. M. CARDOZO, O. S. NEGRETTE, J. D. MARCO, R. ZACCA, C. MEZA, A. JUAREZ, H. ROJO, et al. (2004)
Am J Trop Med Hyg 71, 590-593
   Abstract »    Full Text »    PDF »
RATIONALIZING HISTORICAL SUCCESSES OF MALARIA CONTROL IN AFRICA IN TERMS OF MOSQUITO RESOURCE AVAILABILTY MANAGEMENT.
G. F. KILLEEN, A. SEYOUM, and B. G. J. KNOLS (2004)
Am J Trop Med Hyg 71, 87-93
   Abstract »    Full Text »    PDF »
PREDICTING TRIATOMA DIMIDIATA ABUNDANCE AND INFECTION RATE: A RISK MAP FOR NATURAL TRANSMISSION OF CHAGAS DISEASE IN THE YUCATAN PENINSULA OF MEXICO.
E. DUMONTEIL and S. GOURBIERE (2004)
Am J Trop Med Hyg 70, 514-519
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)