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Science 29 March 1946:
Vol. 103. no. 2674, pp. 399 - 401
DOI: 10.1126/science.103.2674.399
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Articles

Interference With the Antibacterial Action of Streptomycin by Reducing Agents

AMEDEO BONDI JR. 1, CATHERINE C. DIETZ 1, and EARLE H. SPAULDING 1

1 Temple University School of Medicine, Philadelphia

The antibacterial activity of streptomycin in infusion agar plate cultures of E. coli and other bacteria is diminished by anaerobic incubation. The bacteriostatic activity of this antibiotic for E. coli is reduced in the presence of cysteine, sodium thioglycollate, stannous chloride, sodium bisulfite, sodium hydrosulfite, sodium formate, and sodium thiosulfate. Cysteine was the most active of the agents tested. Further investigation is necessary to determine the nature of this interference. It is possible that this phenomenon is related to the mode of action of streptomycin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
MICROBIAL SENSITIVITY TEST IN MANAGEMENT OF URINARY TRACT INFECTIONS.
K. A. Mian (1959)
JAMA 170, 934-938
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