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Science 20 December 1996:
Vol. 274. no. 5295, pp. 2097 - 2100
DOI: 10.1126/science.274.5295.2097
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Reports

Enhancement of Class II-Restricted T cell Responses by Costimulatory NK Receptors for Class I MHC Proteins

Ofer Mandelboim, * Daniel M. Davis, * Hugh T. Reyburn, * Mar Valés-Gómez, Eric G. Sheu, Laszlo Pazmany, Jack L. Strominger dagger

An important feature of the human immune system is the ability of T cells to respond to small quantities of antigen. Class II major histocompatibility complex (MHC)-restricted T cells that expressed a costimulatory natural killer (NK) cell receptor for class I MHC proteins were cloned. In the presence of low doses of superantigen, the proliferative response of these T cell clones was three- to ninefold greater when the T cells were costimulated by way of the NK receptor. Thus, the action of costimulatory NK receptors on T cells may play a significant role in initiating and sustaining immune responses.

Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: jlstrom{at}fas.harvard.edu


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