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Science 20 December 1996:
Vol. 274. no. 5295, pp. 2057 - 2059
DOI: 10.1126/science.274.5295.2057
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Reports

Loss of Heterozygosity in Normal Tissue Adjacent to Breast Carcinomas

Guoren Deng, You Lu, Galina Zlotnikov, Ann D. Thor, Helene S. Smith *

Loss of heterozygosity (LOH) was detected in morphologically normal lobules adjacent to breast cancers. The most frequent aberration was at chromosome 3p22-25; of ten cases with this LOH in the carcinoma, six displayed the same LOH in adjacent normal lobules. This suggests that in a subset of sporadic breast cancers, a tumor suppresser gene at 3p22-25 may be important in initiation or early progression of tumorigenesis. Among sixteen breast cancers with LOH at 17p13.1 and five breast cancers with LOH at 11p15.5, one case each displayed the same LOH in adjacent normal lobules. Thus the molecular heterogeneity that characterizes invasive breast cancers may occur at the earliest detectable stages of progression.

G. Deng, Y. Lu, G. Zlotnikov, Geraldine Brush Cancer Research Institute, California Pacific Medical Center, 2330 Clay Street, San Francisco, CA 94619, USA.
A. D. Thor, Department of Pathology, Northwestern University School of Medicine, Evanston Hospital, 2650 Ridge Avenue, Evanston, IL 60201, USA.
H. S. Smith, Geraldine Brush Cancer Research Institute, California Pacific Medical Center, 2330 Clay Street, San Francisco, CA 94619, and Department of Medicine, University of California, San Francisco, CA 94143, USA.
*   To whom correspondence should be addressed.


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Loss of Heterozygosity at D14S62 and Metastatic Potential of Breast Cancer.
P. O'Connell, K. Fischbach, S. Hilsenbeck, S. K. Mohsin, S. A. W. Fuqua, G. M. Clark, C. K. Osborne, and D. C. Allred (1999)
J Natl Cancer Inst 91, 1391-1397
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Elevated retinoic acid receptor beta 4 protein in human breast tumor cells with nuclear and cytoplasmic localization.
K. M. Sommer, L. I. Chen, P. M. Treuting, L. T. Smith, and K. Swisshelm (1999)
PNAS 96, 8651-8656
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Presence of Tumor DNA in Plasma of Breast Cancer Patients: Clinicopathological Correlations.
J. M. Silva, G. Dominguez, J. M. Garcia, R. Gonzalez, M. J. Villanueva, F. Navarro, M. Provencio, S. San Martin, P. Espana, and F. Bonilla (1999)
Cancer Res. 59, 3251-3256
   Abstract »    Full Text »    PDF »
Retinoic Acid-mediated G1-S-Phase Arrest of Normal Human Mammary Epithelial Cells Is Independent of the Level of p53 Protein Expression.
V. L. Seewaldt, E. C. Dietze, B. S. Johnson, S. J. Collins, and M. B. Parker (1999)
Cell Growth Differ. 10, 49-59
   Abstract »    Full Text »
Immuno-LCM: Laser Capture Microdissection of Immunostained Frozen Sections for mRNA Analysis.
F. Fend, M. R. Emmert-Buck, R. Chuaqui, K. Cole, J. Lee, L. A. Liotta, and M. Raffeld (1999)
Am. J. Pathol. 154, 61-66
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Phenotype and Genotype of Advanced Premalignant Head and Neck Lesions After Chemopreventive Therapy.
L. Mao, A. K. El-Naggar, V. Papadimitrakopoulou, D. M. Shin, H. C. Shin, Y. Fan, X. Zhou, G. Clayman, J. J. Lee, J. S. Lee, et al. (1998)
J Natl Cancer Inst 90, 1545-1551
   Abstract »    PDF »
The Long and Short of Chromosome 11 in Breast Cancer.
I. F. Newsham (1998)
Am. J. Pathol. 153, 5-9
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Loss of Heterozygosity on Chromosome 11p15 during Histological Progression in Microdissected Ductal Carcinoma of the Breast.
J. H. Lichy, M. Zavar, M. M. Tsai, T. J. O'Leary, and J. K. Taubenberger (1998)
Am. J. Pathol. 153, 271-278
   Abstract »    Full Text »    PDF »
Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis.
T. Yamada, A. T. De Souza, S. Finkelstein, and R. L. Jirtle (1997)
PNAS 94, 10351-10355
   Abstract »    Full Text »    PDF »
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging.
A. Krtolica, S. Parrinello, S. Lockett, P.-Y. Desprez, and J. Campisi (2001)
PNAS 98, 12072-12077
   Abstract »    Full Text »    PDF »


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