The Flavivirus Precursor Membrane-Envelope Protein Complex: Structure and Maturation
Long Li, Shee-Mei Lok, I-Mei Yu, Ying Zhang, Richard J. Kuhn, Jue Chen, Michael G. Rossmann

Supporting Online Material

This supplement contains:
Materials and Methods
Figs. S1 to S3
Tables S1 to S4
References

This file is in Adobe Acrobat PDF format.

Other Supporting Online Material for this manuscript includes the following:
Movie S1

Movie s1
Movie showing one trimeric spike of the immature virus at neutral pH. The three prM-E glycoprotein heterodimers, represented by their Ca backbones, are colored red, green and blue. The pr peptides are highlighted in bold. The extended polypeptide chain of the M protein connecting the pr peptide with the M helical, membrane-associated regions are colored black in each heterodimer. The furin cleavage site, marked with a sphere, is hidden inside the spike and, therefore, inaccessible to furin when the virus is in this conformation.

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