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GE and Science Prize for Young Life Scientists

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Science 7 March 2008:
Vol. 319. no. 5868, pp. 1387 - 1391
DOI: 10.1126/science.1152692


De Novo Computational Design of Retro-Aldol Enzymes
Lin Jiang, Eric A. Althoff, Fernando R. Clemente, Lindsey Doyle, Daniela Röthlisberger, Alexandre Zanghellini, Jasmine L. Gallaher, Jamie L. Betker, Fujie Tanaka, Carlos F. Barbas III, Donald Hilvert, Kendall N. Houk, Barry L. Stoddard, David Baker

Supporting Online Material

This supplement contains:
Materials and Methods
SOM Text
Figs. S1 to S8
Tables S1 to S8
References

Download supplement

This file is in Adobe Acrobat PDF format.

Other Supporting Online Material for this manuscript includes the following:
(available at www.sciencemag.org/cgi/content/full/319/5868/1387/DC1)
Design Model Coordinates in PDB Format

Supporting data set. Design model coordinates, in Protein Data Bank (PDB) format. Files are packaged as a compressed archive, in *.zip format; users should download the compressed file to their machine and decompress the file on their local hard drive, using the instructions below.


Instructions for downloading and decompressing files:

  1. Create a temporary folder on your machine's hard drive.
  2. Save the compressed archive to the temporary folder you created, using the links above.
  3. Decompress the compressed file in the temporary folder using decompression software such as WinZip (Windows; www.winzip.com) or StuffIt Expander (Windows and Mac; www.stuffit.com).

PDB files can be opened in any text editor, word processor, or Web browser, and can also be used as input to a variety of molecular modeling and visualization packages.





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