Draft Genome of the Filarial Nematode Parasite Brugia malayi
Elodie Ghedin, Shiliang Wang, David Spiro, Elisabet Caler, Qi Zhao, Jonathan Crabtree, Jonathan E. Allen, Arthur L. Delcher, David B. Guiliano, Diego Miranda-Saavedra, Samuel V. Angiuoli, Todd Creasy, Paolo Amedeo, Brian Haas, Najib M. El-Sayed, Jennifer R. Wortman, Tamara Feldblyum, Luke Tallon, Michael Schatz, Martin Shumway, Hean Koo, Steven L. Salzberg, Seth Schobel, Mihaela Pertea, Mihai Pop, Owen White, Geoffrey J. Barton, Clotilde K. S. Carlow, Michael J. Crawford, Jennifer Daub, Matthew W. Dimmic, Chris F. Estes, Jeremy M. Foster, Mehul Ganatra, William F. Gregory, Nicholas M. Johnson, Jinming Jin, Richard Komuniecki, Ian Korf, Sanjay Kumar, Sandra Laney, Ben-Wen Li, Wen Li, Tim H. Lindblom, Sara Lustigman, Dong Ma, Claude Maina, David Martin, James P. McCarter, Larry McReynolds, Makedonka Mitreva, Thomas B. Nutman, John Parkinson, José M. Peregrín-Alvarez, Catherine Poole, Qinghu Ren, Lori Saunders, Ann E. Sluder, Katherine Smith, Mario Stanke, Thomas R. Unnasch, Jenna Ware, Aguan D. Wei, Gary Weil, Deryck J. Williams, Yinhua Zhang, Steven A. Williams, Claire Fraser-Liggett, Barton Slatko, Mark L. Blaxter, Alan L. Scott

Supporting Online Material

This supplement contains:
Materials and Methods (with Figs. A, B, and C)
SOM Text: Supplemental Analyses (with Fig. D and Tables A and B)
References
Figures S1 to S8
Tables S1 to S8 (as separate files)

This file is in Adobe Acrobat PDF format.

Other Supporting Online Material for this manuscript includes the following:
(available at www.sciencemag.org/cgi/content/full/317/5845/1756/DC1)
Table S1. List of Brugia malayi proteins coded by the predicted gene models.
Table S2. Complete list of B. malayi genes found in putative operons, with their C. elegans orthologs.
Table S3. Brugia malayi proteins that do not cluster with C. briggsae, C. elegans, and D. melanogaster.
Table S4. Clusters of orthologous genes in B. malayi and C. briggsae; not in C. elegans and D. melanogaster.
Table S5. Clusters of orthologous genes in B. malayi and C. elegans; not in C. briggsae and D. melanogaster.
Table S6. Clusters of orthologous genes in B. malayi and D. melanogaster; not in C. briggsae and C. elegans.
Table S7. Clusters of orthologous genes in B. malayi, C. briggsae and C. elegans; not in D. melanogaster.
Table S8. Clusters of orthologous genes in B. malayi, C. briggsae, C. elegans and D. melanogaster.
Table S9. Domains shared by B. malayi, C. briggsae, C. elegans, and D. melanogaster.
Table S10. Taxonomic split of B. malayi proteins.
Table S11. Molting genes discovered via C. elegans RNAi screens and their putative B. malayi orthologs.
Table S12. Nuclear Receptor genes in the B. malayi genome.
Table S13. List of collagen genes in the B. malayi genome.
Table S14. B. malayi genes involved in neuronal signaling.
Table S15. Kinases shared by all three nematodes.
Table S16. RNAi pathway genes present and missing in B. malayi.
Table S17. B. malayi genes that may interact with or protect from host immune attack.