Assembly of Cell Regulatory Systems Through Protein Interaction Domains T. Pawson and P. Nash

STKE: A Series on Protein Domains in Signal Transduction

The following related articles have been posted on Science's Signal Transduction Knowledge Environment

15 July 2003

Reviews

• SH2 and PTB Domains in Tyrosine Kinase Signaling Joseph Schlessinger and Mark A. Lemmon
  Motifs that recognize phosphorylated tyrosines are essential regulators of cellular signaling events.
  [Gloss] [Abstract] [Full Text] [PDF]

• A Kelch b-Propeller Featuring as a Gb Structural Mimic: Reinventing the Wheel? Jan Gettemans, Kris Meerschaert, Joël Vandekerckhove, and Veerle De Corte
  Structural similarity may allow proteins with diverse primary sequences to serve in the G protein heterotrimer.
  [Summary] [Full Text] [PDF]

Teaching Resources

• Activation of Ras by Grb2-SOS: Demonstrating an Assembly Role of SH3 Domains Ali Zarrinpar, Roby P. Bhattacharyya, Wendell A. Lim, and Nancy R. Gough
  A simple animation showing how SH3 domains participate in mitogen-activated protein kinase signaling.
  [Summary] [Resource]

22 April 2003

• Gene Regulation at the RNA Layer: RNA-Binding Proteins in Intercellular Signaling Networks Paul Lasko
  How extracellular signals can regulate RNA processing, transport, and translation to control gene expression.
  [Gloss] [Abstract] [Full Text] [PDF]



• PDZ Domain Proteins: Plug and Play! Claire Nourry, Seth G. N. Grant, and Jean-Paul Borg
  PDZ domains provide the scaffold for functional complexes implicated in health and disease in polar cells.
  [Gloss] [Abstract] [Full Text] [PDF]



• The Structure and Function of Proline Recognition Domains Ali Zarrinpar, Roby P. Bhattacharyya, and Wendell A. Lim
  Understanding the structural basis of a commonly used motif present in many proteins involved in signal transduction.
  [Gloss] [Abstract] [Full Text] [PDF] [Structures]