An in Vivo Map of the Yeast Protein Interactome
Kirill Tarassov, Vincent Messier, Christian R. Landry, Stevo Radinovic, Mercedes M. Serna Molina, Igor Shames, Yelena Malitskaya, Jackie Vogel, Howard Bussey, Stephen W. Michnick

Supporting Online Material

This supplement contains:
Materials and Methods
Figs. S1 to S11
References

This file is in Adobe Acrobat PDF format.

Other Supporting Online Material for this manuscript includes the following: (available at www.sciencemag.org/cgi/content/full/1153878/DC1)
Tables S1 to S9 as zipped archives
Data Set S1 as zipped archive
Software package for viewing Data Set S1; versions for Windows, Mac OSX, and Linux
PDF documentation for above software package

Tables S1 to S9. Data tables, in PDF and Microsoft Excel format, supporting the presentation in the main paper; descriptions of tables appear in main SOM file. Files are packaged as a compressed archive, in *.zip format; users should download the compressed file to their machine and decompress the file on their local hard drive, using the instructions below.

• 1153878s_tables.zip (1.1 MB)

Dataset S1 ASCII file containing clustered DHFR PCA network as described in Fig. 4 of main paper. File is packaged in a compressed archive, in *.zip format; users should download the compressed file to their machine and decompress the file on their local hard drive, using the instructions below. [Note: The file is in a format designed to be opened and visualized using iVici, a software package written by the authors. Please see below for details.

• 1153878s_data.zip (< 0.1 MB)

Instructions for downloading and decompressing files:

1. Create a temporary folder on your machine's hard drive.
2. Save the compressed archive to the temporary folder you created, using the links above.
3. Decompress the compressed file in the temporary folder using decompression software such as WinZip (Windows; www.winzip.com) or StuffIt Expander (Windows and Mac; www.stuffit.com).

Excel files can be opened and viewed using Microsoft Excel, the spreadsheet module of the freely downloadable Open Office suite, or the freely downloadable Excel Viewer available from Microsoft. PDF files can be opened using Adobe Reader software. ASCII files can be opened with any text editor or word processor.

Note on Dataset S1. The ASCII data file provided above is formatted to be visualized using iVici, a Java software package written by the authors. The links below provide access to zip files containing versions of the software for Windows, Mac OSX, and Linux, as well as a PDF file of the authors' software documentation. (The software also requires that the Java 2 Platform, 1.4 or above, be installed on the user's machine.) More recent versions and further information may be available at http://michnick.bcm.umontreal.ca/ivici/. [Note: Science takes no responsibility for the software or its function, and is providing these links solely for the convenience of readers. Users should download and use the software at their own risk. Any questions regarding the software and its function should be directed to the authors.]

iVici Software Packages:

• Windows version
• Mac OSX version
• Linux version
• PDF Documentation