Fig. 4. Dynamic regulation of menin and its target genes during facultative islet growth in obese A^y mice. (A) Blood glucose concentration and (B) body mass in 12-week-old control and A^y littermate mice fed ad libitum. (C) Real-time RT-PCR analysis of Men1, p18, and p27 mRNA levels in islets from control or A^y littermate mice. (D) Western blot analysis of the indicated proteins in islets from control and A^y littermate mice. (E and F) Detection of insulin (green) and menin (red) in islet ß-cells from control (E) and A^y littermate (F) mice. Scale bar, 50 µm. [View Larger Version of this Image (177K JPEG file)]

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