Figure 2

Fig. 2. Properties and biogenesis of piRNAs. (A) Features of Aub- and AGO3-associated piRNAs in Drosophila. Indicated are the 5' U bias in Aub-bound piRNAs, the 10A bias in AGO3-bound piRNAs, the 5' phosphate, and the 3' O-methylation. (B) Ping-Pong model of piRNA biogenesis in Drosophila. Primary piRNAs are generated by an unknown mechanism and/or are maternally deposited. Those with a target are specifically amplified via a Slicer-dependent loop involving AGO3 and Aub. [View Larger Version of this Image (137K JPEG file)]

 

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