Figure 1

Fig. 1. Linkage disequilibrium decay around A44871G in European Americans. (A) Haplotype frequency in European Americans (CEU). Blue bars are the derived haplotypes marked by the G allele. (B) Decay of extended haplotype homozygosity (EHH) around A44871G. (C) The significance of the LRH test at each marker is evaluated empirically by comparing with the genome-wide data from HapMap, matched with regard to breakdown of homozygosity. The most extreme P value of 0.03 is not striking when compared against the lowest P value seen in 1000 comparison regions, 90% of which show stronger evidence for selection at some distance. (D) The extent of the haplotype around the G allele (red dot, defined as the span for which EHH > 0.35), in comparison with alleles of matched frequency in CEU from HapMap on chromosome 1. This is well within the 95% central range of HapMap, whether plotted by physical distance (this figure) or genetic distance (fig. S3). To match the marker density of HapMap Phase I, we randomly dropped SNPs from ASPM until we had 1 SNP every 5 kb. With this lower density, the span of the G haplotype is 285 kb. [View Larger Version of this Image (108K JPEG file)]

 

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