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Assembly of Cell Regulatory Systems Through Protein Interaction Domains
T. Pawson and P. Nash
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Related STKE Articles
STKE: A Series on Protein Domains in Signal Transduction
The following related articles have been posted on Science's Signal Transduction Knowledge Environment
15 July 2003
Reviews
- SH2 and PTB Domains in Tyrosine Kinase Signaling Joseph Schlessinger and Mark A. Lemmon
Motifs that recognize phosphorylated tyrosines are essential regulators of cellular signaling events.
[Gloss] [Abstract] [Full Text] [PDF]
Perspectives
- A Kelch b-Propeller Featuring as a Gb Structural Mimic: Reinventing the Wheel?
Jan Gettemans, Kris Meerschaert, Joël Vandekerckhove, and Veerle De Corte
Structural similarity may allow proteins with diverse primary sequences to serve in the G protein heterotrimer.
[Summary] [Full Text] [PDF]
Teaching Resources
- Activation of Ras by Grb2-SOS: Demonstrating an Assembly Role of SH3 Domains Ali Zarrinpar, Roby P. Bhattacharyya, Wendell A. Lim, and Nancy R. Gough
A simple animation showing how SH3 domains participate in mitogen-activated protein kinase signaling.
[Summary] [Resource]
22 April 2003
Reviews
- Gene Regulation at the RNA Layer: RNA-Binding Proteins in Intercellular Signaling Networks Paul Lasko
How extracellular signals can regulate RNA processing, transport, and translation to control gene expression.
[Gloss] [Abstract] [Full Text] [PDF]
- PDZ Domain Proteins: Plug and Play! Claire Nourry, Seth G. N. Grant, and Jean-Paul Borg
PDZ domains provide the scaffold for functional complexes implicated in health and disease in polar cells.
[Gloss] [Abstract] [Full Text] [PDF]
- The Structure and Function of Proline Recognition Domains Ali Zarrinpar, Roby P. Bhattacharyya, and Wendell A. Lim
Understanding the structural basis of a commonly used motif present in many proteins involved in signal transduction.
[Gloss] [Abstract] [Full Text] [PDF] [Structures]
