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Reliability of Protocol Reviews for Animal Research
Scott Plous and Harold Herzog
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Supplementary Material
| Supplemental Table 1. Description of animal research protocols submitted by IACUCs. Table cells contain frequency of protocols, with parenthetical numbers indicating column percentages within each cell. |
| Research animal* |
| Type of protocol | Cats, dogs, or primates | Rats | Other mammals | Nonmammals | Total |
Drug or alcohol study
Yes
No | 1 (12.5)
7 (87.5) | 54 (72.0)
21 (28.0) | 11 (32.4)
23 (67.6) | 10 (30.3)
23 (69.7) | 76 (50.7)
74 (49.3) |
Involved surgery
Yes
No | 5 (62.5)
3 (37.5) | 48 (64.0)
27 (36.0) | 6 (17.6)
28 (82.4) | 7 (21.2)
26 (78.8) | 66 (44.0)
84 (56.0) |
Involved food or water deprivation
Yes
No | 4 (50.0)
4 (50.0) | 24 (32.0)
51 (68.0) | 6 (17.6)
28 (82.4) | 8 (24.2)
25 (75.8) | 42 (28.0)
108 (72.0) |
Animals euthanized
Yes
No | 5 (62.5)
3 (37.5) | 70 (93.3)
5 (6.7) | 18 (52.9)
16 (47.1) | 15 (45.5)
18 (54.5) | 108 (72.0)
42 (28.0) |
Main funding was external
Yes
No | 4 (50.0)
4 (50.0) | 36 (48.0)
39 (52.0) | 18 (52.9)
16 (47.1) | 14 (42.4)
19 (57.6) | 72 (48.0)
78 (52.0) |
Approved as written by original IACUC
Yes
No | 4 (50.0)
4 (50.0) | 30 (40.0)
45 (60.0) | 17 (50.0)
17 (50.0) | 21 (63.6)
12 (36.4) | 72 (48.0)
78 (52.0) |
| Total number of protocols | 8 | 75 | 34 | 33 | 150 |
*In one case, a protocol involved both rats and primates (categorized in the table as "primates") and in four cases, protocols involved rats and other mammals (categorized as "other mammals").
Funding source as described in protocols. |
Supplemental Figure 1. Pain classification scale, adapted from (7).

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