Samuel Aparicio, ^{2, 1 *} Jarrod Chapman, ³ Elia Stupka, ^{1 *} Nik Putnam, ³ Jer-ming Chia, ¹ Paramvir Dehal, ³ Alan Christoffels, ¹ Sam Rash, ³ Shawn Hoon, ¹ Arian F. Smit, ⁴ Maarten D. Sollewijn Gelpke, ³ Jared Roach, ⁴ Tania Oh, ¹ Isaac Y. Ho, ³ Marie Wong, ¹ Chris Detter, ³ Frans Verhoef, ¹ Paul Predki, ³ Alice Tay, ¹ Susan Lucas, ³ Paul Richardson, ³ Sarah F. Smith, ⁵ Melody S. Clark, ⁵ Yvonne J. K. Edwards, ⁵ Norman Doggett, ⁶ Andrey Zharkikh, ⁷ Sean V. Tavtigian, ⁷ Dmitry Pruss, ⁷ Mary Barnstead, ⁸ Cheryl Evans, ⁸ Holly Baden, ⁸ Justin Powell, ⁹ Gustavo Glusman, ⁴ Lee Rowen, ⁴ Leroy Hood, ⁴ Y. H. Tan, ¹ Greg Elgar, ^{5 *} Trevor Hawkins, ^{3 *} Byrappa Venkatesh, ^{1 *} Daniel Rokhsar, ^{3 *} Sydney Brenner ^{1, 10 *}

¹Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609.
²University of Cambridge, Department of Oncology, Hutchison–MRC Research Centre, Cambridge CB2 2XZ, UK.
³U.S. DoE Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.
⁴Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA.
⁵MRC UK HGMP Resource Centre, Hinxton, Cambridge CB10 1SB, UK.
⁶Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
⁷Myriad Genetics Inc, 320 Wakara Way, Salt Lake City, UT 84108, USA.
⁸Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA.
⁹Paradigm Therapeutics Ltd, Physiological Laboratory, Cambridge CB2 3EG, UK.
¹⁰Salk Institute, 10010 North Torrey Pines Road, La Jolla, San Diego CA 92037–1099, USA.

*To whom correspondence and requests for material should be addressed: E-mail: saa1000@cam.ac.uk (S.A.), elia@fugu-sg.org (E.S.), gelgar@hgmp.mrc.ac.uk (G.E.), trevor.hawkins@am.amershambiosciences.com (T.H.), mcbbv@imcb.nus.edu.sg (B.V), dsrokhsar@lbl.gov (D.R.), sbrenner@salk.edu (S.B.)

Present address: Amersham Biosciences, 928 East Arques Avenue, Sunnyvale CA 945085, USA.