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Science 14 September 2007:
Vol. 317. no. 5844, p. 1500
DOI: 10.1126/science.1138179
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Technical Comments

Comment on "The Consensus Coding Sequences of Human Breast and Colorectal Cancers"

William F. Forrest1 and Guy Cavet2*

1 Department of Biostatistics, Genentech, Inc., South San Francisco, CA 94080, USA.
2 Department of Bioinformatics, Genentech, Inc., South San Francisco, CA 94080, USA.


Figure 1 Fig. 1. CaMP scores from original and revised analyses. Black circles indicate CaMP scores calculated according to (1). Green squares indicate CaMP scores calculated using P values reflecting whether a gene has more mutations than expected by chance. Blue diamonds indicate CaMP scores calculated using P values reflecting whether a gene's mutational profile is consistent with the background mutation rates. Dotted lines indicate the CaMP score threshold for CAN genes. (A) Results for breast cancer (results for TP53 are off scale and not shown). (B) Results for colorectal cancer (results for TP53, APC, and KRAS are off scale and not shown). [View Larger Version of this Image (14K GIF file)]
 

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Science. ISSN 0036-8075 (print), 1095-9203 (online)