Modulation of Neuronal Interactions Through Neuronal Synchronization
Thilo Womelsdorf1*
,
Jan-Mathijs Schoffelen1*,
Robert Oostenveld1,
Wolf Singer2,3,
Robert Desimone4,5,
Andreas K. Engel6 and
Pascal Fries1,7
1 F. C. Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, Netherlands.
2 Department of Neurophysiology, Max Planck Institute for Brain Research, 60528 Frankfurt, Germany.
3 Frankfurt Institute for Advanced Studies, Johann Wolfgang Goethe University, 60438 Frankfurt, Germany.
4 Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.
5 McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
6 Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
7 Department of Biophysics, Radboud University Nijmegen, 6525 EZ Nijmegen, Netherlands.
|
Fig. 1. Precise timing between rhythmic neuronal activities determines the strength of their mutual influence. (A) Sketch of three groups of neurons, each rhythmically active (LFP oscillations with spikes in troughs). Time windows for effective communication are either aligned (red and blue group) or not aligned (red and gray group). (B and C) Average phase-coherence spectrum across all (B) MUA-MUA and (C) MUA-LFP pairs (area 17 data) and corresponding distributions of mean phase relations at 60 Hz. (D) Trialwise phase relations from an example MUA-MUA pair. Phase relations were sorted into bins (light and dark gray ring segments) aligned to the mean phase relation (red line). (E) Spearman rank correlation coefficients between the two MUAs' 60-Hz power as a function of their phase relation. (The solid line indicates a cosine fit.) (F and G) Same as (D) and (E), but with one MUA substituted by the respective LFP. (H and I) Example MUA-LFP pair from the area 17 data set demonstrating that coherence does not necessarily result in phase-relation–dependent power correlations. (H) Coherence with a clear peak around 60 Hz. (I) Power correlations as a function of phase relations, showing no consistent relation.
[View Larger Version of this Image (47K GIF file)]
|
|
|
Fig. 2. Phase-relation–dependent modulation of power correlations is frequency specific. (A) Average power correlation as a function of phase relation (x axis) and frequency (y axis) for MUA-MUA pairs recorded in cat area 17. (B) Same as (A), but for MUA-LFP pairs. (C) Modulation depth of the cosine function fitted to the phase-relation–dependent power correlations. Gray bars indicate significant frequencies (P < 0.05, multiple comparisons corrected). (Right) Average phase-relation–dependent power correlation at 60 Hz. (D and E) Same as (C), but for (D) cat area 18x21a and (E) monkey area V1.
[View Larger Version of this Image (42K GIF file)]
|
|
|
Fig. 3. Good phase relations precede strong power correlations. (A) Spearman rank correlation coefficient (y axis) between the power correlation and the "goodness" of the phase relation across all MUA-LFP pairs of all data sets for relative time lags (x axis) between –200 and 200 ms. (B) Detail from (A), demonstrating the peak of the cross-correlation function at –5 ms. A latency of the peak outside the gray shaded area is significant at P < 0.05.
[View Larger Version of this Image (16K GIF file)]
|
|
|
Fig. 4. Spatial selectivity of phase-relation–dependent power correlation. (A) Scatterplot shows the distribution of trialwise phase relations between groups A and B (y axis) and between groups A and C (x axis) for an example triplet at 60 Hz. Equations define how A-B power correlations from each quadrant were combined for the results shown in (B to D). In the equations, c(ABq) denotes the A-B power correlation across trials in quadrant q (where q is 1, 2, 3, or 4). (B) A-B power correlation as a function of the A-B phase relation [irrespective of the A-C phase relation (red line)] and as a function of the A-C phase relation [irrespective of the A-B phase relation (blue line)]. Gray bars indicate frequencies with significant differences (P < 0.05, multiple comparisons corrected). The y axis denotes the differences in power correlations according to the equators shown in (A). (C and D) Same as (B), but for (C) monkey area V1 and (D) monkey area V4.
[View Larger Version of this Image (31K GIF file)]
|
|
