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Science 24 November 2006:
Vol. 314. no. 5803, p. 1243
DOI: 10.1126/science.1129919
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Technical Comments

Response to Comment on Nishio et al. on Diabetes Reversal in NOD Mice

Junko Nishio, Jason L. Gaglia, Stuart E. Turvey*, Christopher Campbell, Christophe Benoist{dagger} and Diane Mathis{dagger}

Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, and Harvard Stem Cell Institute, 1 Joslin Place, Boston, MA 02215, USA.


Figure 1 Fig. 1. Mixing experiments demonstrating the sensitivity of the SNP assay used in (2). The values shown indicate the ratio of NOD to B6 DNA mixed in one tube. Results are shown for the PCR assay specific for SNP rs4151928; the NOD versus B6 allele is detected as FAM or VIC fluorescence, respectively. Ratios of 97:3 are detectable at 600 pg of mixed DNA. Similar results were observed for the other two SNPs used in (2). [View Larger Version of this Image (17K GIF file)]
 

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Science. ISSN 0036-8075 (print), 1095-9203 (online)