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Science 24 November 2006:
Vol. 314. no. 5803, p. 1243
DOI: 10.1126/science.1129811
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Technical Comments

Comment on Papers by Chong et al., Nishio et al., and Suri et al. on Diabetes Reversal in NOD Mice

Denise L. Faustman1*, Simon D. Tran2, Shohta Kodama3, Beatrijs M. Lodde4, Ildiko Szalayova4, Sharon Key4, Zsuzsanna E. Toth4 and Éva Mezey4*

1 Massachusetts General Hospital, Charlestown, MA 02129, USA.
2 McGill University, Montreal, Quebec, Canada.
3 Brigham and Women's Hospital, Boston, MA 02215, USA.
4 National Institutes of Health, Bethesda, MD 20892, USA.


Figure 1 Fig. 1. Pancreatic sections from successfully treated female NOD mice show insulin-containing (green) islet cells with Y chromosomes (red) (A, B, and C). Each image is from a different successfully treated NOD mouse that received live spleen cells (11, 12). A Y chromosome in each islet that is colocalized with insulin is shown with the grid in all three planes from one level of the Z stack. Arrows in each image point to additional colocalizations of Y chromosomes and insulin-producing cells. [View Larger Version of this Image (159K GIF file)]
 

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Science. ISSN 0036-8075 (print), 1095-9203 (online)