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Science 12 May 2006:
Vol. 312. no. 5775, p. 848
DOI: 10.1126/science.1110994
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Technical Comments

Response to Comment on "Evidence for Positive Epistasis in HIV-1"

Sebastian Bonhoeffer1*, Colombe Chappey2, Neil T. Parkin2, Jeannette M. Whitcomb2 and Christos J. Petropoulos2

1 Institute of Integrative Biology, ETH Zurich, ETH Zentrum CHN, CH-8092 Zurich, Switzerland.
2 Monogram BioSciences, Inc., 345 Oyster Point Boulevard, South San Francisco, CA 94080–1913, USA.


Figure 1 Fig. 1. Correction of figure 1B in (2), showing mean and standard error (gray dots and bars) of log fitness as a function of the number of amino acids differing from the reference virus (Hamming distance) for all sequences in the data set. The original figure mistakenly showed the standard deviation divided by the number of observations rather than the standard error. This figure reproduces the graph with the correct standard errors. Our mistake does not affect mean and 95% confidence intervals of the shown nonparametric regression, because these were calculated based on the actual data. [View Larger Version of this Image (17K GIF file)]
 

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