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Originally published in Science Express on 23 March 2006
Science 21 April 2006:
Vol. 312. no. 5772, p. 399
DOI: 10.1126/science.1125548
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Brevia

H5N1 Virus Attachment to Lower Respiratory Tract

Debby van Riel, Vincent J. Munster, Emmie de Wit, Guus F. Rimmelzwaan, Ron A. M. Fouchier, Ab D. M. E. Osterhaus and Thijs Kuiken*

Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands.


Figure 1 Fig. 1. Attachment of H5N1 virus to respiratory tissues of humans and four animal species. In the trachea, H5N1 virus—visible as red-brown staining—attached only to epithelial cells of mice. In the alveoli, H5N1 virus attached predominantly to type II pneumocytes (arrowheads) in humans and all animal species except the macaque, where attachment was predominantly to type I pneumocytes (arrows). [View Larger Version of this Image (73K GIF file)]
 

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Science. ISSN 0036-8075 (print), 1095-9203 (online)