Science 24 December 1993: Vol. 262. no. 5142, pp. 1980 - 1981 DOI: 10.1126/science.8266092

Prev | Table of Contents | Next

Articles

Cancer Genome Sequencing--An Interim Analysis.

E. J. Fox, J. J. Salk, and L. A. Loeb (2009)
Cancer Res. 69, 4948-4950
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Alterations in K-ras and p53 Cancer Genes in Lung Neoplasms from B6C3F1 Mice Exposed to Cumene.

H.-H. L. Hong, T.-V. T. Ton, Y. Kim, N. Wakamatsu, N. P. Clayton, P.-C. Chan, R. C. Sills, and S. A. Lahousse (2008)
Toxicol Pathol 36, 720-726
 |  Abstract »  |  Full Text »  |  PDF »

Methylation-Acetylation Interplay Activates p53 in Response to DNA Damage.

G. S. Ivanov, T. Ivanova, J. Kurash, A. Ivanov, S. Chuikov, F. Gizatullin, E. M. Herrera-Medina, F. Rauscher III, D. Reinberg, and N. A. Barlev (2007)
Mol. Cell. Biol. 27, 6756-6769
 |  Abstract »  |  Full Text »  |  PDF »

p53-Dependent NDRG1 expression induces inhibition of intestinal epithelial cell proliferation but not apoptosis after polyamine depletion.

A.-H. Zhang, J. N. Rao, T. Zou, L. Liu, B. S. Marasa, L. Xiao, J. Chen, D. J. Turner, and J.-Y. Wang (2007)
Am J Physiol Cell Physiol 293, C379-C389
 |  Abstract »  |  Full Text »  |  PDF »

172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant.

J. Lu, L.-E Wang, P. Xiong, E. M. Sturgis, M. R. Spitz, and Q. Wei (2007)
Carcinogenesis 28, 988-994
 |  Abstract »  |  Full Text »  |  PDF »

The p53 Isoform {Delta}p53 Lacks Intrinsic Transcriptional Activity and Reveals the Critical Role of Nuclear Import in Dominant-Negative Activity.

W. M. Chan and R. Y.C. Poon (2007)
Cancer Res. 67, 1959-1969
 |  Abstract »  |  Full Text »  |  PDF »

Ubiquitination of p53 at Multiple Sites in the DNA-Binding Domain.

W. M. Chan, M. C. Mak, T. K. Fung, A. Lau, W. Y. Siu, and R. Y.C. Poon (2006)
Mol. Cancer Res. 4, 15-25
 |  Abstract »  |  Full Text »  |  PDF »

{Delta}Np63{alpha} Up-Regulates the Hsp70 Gene in Human Cancer.

G. Wu, M. Osada, Z. Guo, A. Fomenkov, S. Begum, M. Zhao, S. Upadhyay, M. Xing, F. Wu, C. Moon, et al. (2005)
Cancer Res. 65, 758-766
 |  Abstract »  |  Full Text »  |  PDF »

The adaptive imbalance to genotoxic stress: genome guardians rear their ugly heads.

L. J. Hofseth (2004)
Carcinogenesis 25, 1787-1793
 |  Abstract »  |  Full Text »  |  PDF »

How Many Mutant p53 Molecules Are Needed To Inactivate a Tetramer?.

W. M. Chan, W. Y. Siu, A. Lau, and R. Y. C. Poon (2004)
Mol. Cell. Biol. 24, 3536-3551
 |  Abstract »  |  Full Text »  |  PDF »

The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations: A role for UVA in human skin carcinogenesis.

N. S. Agar, G. M. Halliday, R. StC. Barnetson, H. N. Ananthaswamy, M. Wheeler, and A. M. Jones (2004)
PNAS 101, 4954-4959
 |  Abstract »  |  Full Text »  |  PDF »

Sequential Alteration of Apoptosis, p53 Expression, and Cell Proliferation in the Rat Pancreas Treated with 4-Hydroxyaminoquinoline 1-Oxide.

T. Imazawa, A. Nishikawa, K. Toyoda, F. Furukawa, M. Mitsui, and M. Hirose (2003)
Toxicol Pathol 31, 625-631
 |  Abstract »  |  PDF »

p53 facilitates degradation of human T-cell leukaemia virus type I Tax-binding protein through a proteasome-dependent pathway.

I. H. Chowdhury, M. Radonovich, R. Mahieux, C. Pise-Masison, S. Muralidhar, and J. N. Brady (2003)
J. Gen. Virol. 84, 897-906
 |  Abstract »  |  Full Text »  |  PDF »

p53 Mutations in Human Aggressive and Nonaggressive Basal and Squamous Cell Carcinomas.

S. Bolshakov, C. M. Walker, S. S. Strom, M. S. Selvan, G. L. Clayman, A. El-Naggar, S. M. Lippman, M. L. Kripke, and H. N. Ananthaswamy (2003)
Clin. Cancer Res. 9, 228-234
 |  Abstract »  |  Full Text »  |  PDF »

Lung cancer * 1: Prevention of lung cancer.

G E Goodman (2002)
Thorax 57, 994-999
 |  Abstract »  |  Full Text »  |  PDF »

Estrogen Up-Regulation of p53 Gene Expression in MCF-7 Breast Cancer Cells Is Mediated by Calmodulin Kinase IV-Dependent Activation of a Nuclear Factor {kappa}B/CCAAT-Binding Transcription Factor-1 Complex.

C. Qin, T. Nguyen, J. Stewart, I. Samudio, R. Burghardt, and S. Safe (2002)
Mol. Endocrinol. 16, 1793-1809
 |  Abstract »  |  Full Text »  |  PDF »

Correlation between cathepsin D expression and p53 protein nuclear accumulation in oesophageal squamous cell carcinoma.

M Ikeguchi, T Sakatani, T Ueta, K Fukuda, S Oka, K Hisamitsu, K Yamaguchi, S Tsujitani, and N Kaibara (2002)
J. Clin. Pathol. 55, 121-126
 |  Abstract »  |  Full Text »  |  PDF »

Polyamine depletion stabilizes p53 resulting in inhibition of normal intestinal epithelial cell proliferation.

L. Li, J. N. Rao, X. Guo, L. Liu, R. Santora, B. L. Bass, and J.-Y. Wang (2001)
Am J Physiol Cell Physiol 281, C941-C953
 |  Abstract »  |  Full Text »  |  PDF »

Modeling multi-component protein-DNA complexes: the role of bending and dimerization in the complex of p53 dimers with DNA.

A. Lebrun, R. Lavery, and H. Weinstein (2001)
Protein Eng. Des. Sel. 14, 233-243
 |  Abstract »  |  Full Text »  |  PDF »

A Mutator Phenotype in Cancer.

L. A. Loeb (2001)
Cancer Res. 61, 3230-3239
 |  Abstract »  |  Full Text »

Detection of p53 Gene Mutations in Human Esophageal Squamous Cell Carcinomas Using a p53 Yeast Functional Assay: Possible Difference in Esophageal Carcinogenesis Between the Young and the Elderly Group.

E. Okuda, H. Osugi, K. Morimura, N. Takada, M. Takemura, S. Fukushima, M. Higashino, and H. Kinoshita (2001)
Clin. Cancer Res. 7, 600-606
 |  Abstract »  |  Full Text »

The p53 Codon 72 Polymorphism and Lung Cancer Risk.

R. Fan, M.-T. Wu, D. Miller, J. C. Wain, K. T. Kelsey, J. K. Wiencke, and D. C. Christiani (2000)
Cancer Epidemiol. Biomarkers Prev. 9, 1037-1042
 |  Abstract »  |  Full Text »

p53 Mutations in Primary and Metastatic Tumors and Circulating Tumor Cells from Colorectal Carcinoma Patients.

Z. A. J. Khan, S. K. Jonas, N. Le-Marer, H. Patel, R. Q. Wharton, A. Tarragona, A. Ivison, and T. G. Allen-Mersh (2000)
Clin. Cancer Res. 6, 3499-3504
 |  Abstract »  |  Full Text »

Tumor progression and metastasis.

J. Yokota (2000)
Carcinogenesis 21, 497-503
 |  Abstract »  |  Full Text »  |  PDF »

p53 mutations experimentally induced by 8-methoxypsoralen plus UVA (PUVA) differ from those found in human skin cancers in PUVA-treated patients.

P. Monti, A. Inga, A. Aprile, P. Campomenosi, P. Menichini, L. Ottaggio, S. Viaggi, G. Ghigliotti, A. Abbondandolo, and G. Fronza (2000)
Mutagenesis 15, 127-132
 |  Abstract »  |  Full Text »  |  PDF »

Immunohistochemical Detection of p53 Tumor-Suppressor Protein is a Poor Indicator of Prognosis for Canine Cutaneous Mast Cell Tumors.

P. E. Ginn, L. E. Fox, J. C. Brower, A. Gaskin, I. D. Kurzman, and P. S. Kubilis (2000)
Vet. Pathol. 37, 33-39
 |  Abstract »  |  Full Text »  |  PDF »

Meta-Analyses of p53 Tumor Suppressor Gene Alterations and Clinicopathological Features in Resected Lung Cancers.

M. C. Tammemagi, J. R. McLaughlin, and S. B. Bull (1999)
Cancer Epidemiol. Biomarkers Prev. 8, 625-634
 |  Abstract »  |  Full Text »

Influence of p53 tumor suppressor protein on bias of DNA repair and apoptotic response in human cells.

M.A. Wani, Q.Z. Zhu, M. El-Mahdy, and A.A. Wani (1999)
Carcinogenesis 20, 765-772
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of polyamine synthesis induces p53 gene expression but not apoptosis.

L. Li, J. Li, J. N. Rao, M. Li, B. L. Bass, and J.-Y. Wang (1999)
Am J Physiol Cell Physiol 276, C946-C954
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism-Based Cancer Prevention Approaches: Targets, Examples, and the Use of Transgenic Mice.

S. D. Hursting, T. J. Slaga, S. M. Fischer, J. DiGiovanni, and J. M. Phang (1999)
J Natl Cancer Inst 91, 215-225
 |  Abstract »  |  Full Text »  |  PDF »

The light at the end of the tunnel for chemical-specific biomarkers: daylight or headlight?.

J. D. Groopman and T. W. Kensler (1999)
Carcinogenesis 20, 1-11
 |  Full Text »  |  PDF »

Putative susceptibility markers of coronary artery disease: association between VDR genotype, smoking, and aromatic DNA adduct levels in human right atrial tissue.

F. J. Van schooten, A. Hirvonen, L. M. Maas, B. A. De mol, J. C. S. kleinjans, D. A. Bell, and J. D. Durrer (1998)
FASEB J 12, 1409-1417
 |  Abstract »  |  Full Text »

Analysis of p53 Gene Mutations in Keloids Using Polymerase Chain Reaction-Based Single-Strand Conformational Polymorphism and DNA Sequencing.

G. M. Saed, D. Ladin, J. Olson, X. Han, Z. Hou, and D. Fivenson (1998)
Arch Dermatol 134, 963-967
 |  Abstract »  |  Full Text »  |  PDF »

p53 in Dermatology.

F. P. Gasparro (1998)
Arch Dermatol 134, 1029-1032
 |  Full Text »  |  PDF »

Review : p53 in the pathogenesis, diagnosis, and treatment of cancer.

E. Perz and J. G. Kuhn (1998)
Journal of Oncology Pharmacy Practice 4, 75-102
 |  Abstract »  |  PDF »

Architectural Accommodation in the Complex of Four p53 DNA Binding Domain Peptides with the p21/waf1/cip1 DNA Response Element.

A. K. Nagaich, V. B. Zhurkin, H. Sakamoto, A. A. Gorin, G. M. Clore, A. M. Gronenborn, E. Appella, and R. E. Harrington (1997)
J. Biol. Chem. 272, 14830-14841
 |  Abstract »  |  Full Text »  |  PDF »

DNA Bending Is Essential for the Site-specific Recognition of DNA Response Elements by the DNA Binding Domain of the Tumor Suppressor Protein p53.

A. K. Nagaich, E. Appella, and R. E. Harrington (1997)
J. Biol. Chem. 272, 14842-14849
 |  Abstract »  |  Full Text »  |  PDF »

p53 Oncoprotein Expression and Gene Mutations in Some Keratoacanthomas.

M. I. Perez, P. Robins, S. Biria, J. Roco, E. Siegel, and A. Pellicer (1997)
Arch Dermatol 133, 189-193
 |  Abstract »  |  PDF »

Cell Cycle Control of Ovarian Granulosa Cells in Tumors and Cysts.

M. J. Costa, J. Walls, A. Dickerman, P. F. Ames, L. M. Roth, and D. Guinee Jr (1996)
International Journal of Surgical Pathology 4, 61-69
 |  Abstract »  |  PDF »

MOLECULAR GENETIC DIFFERENTIATION BETWEEN PRIMARY LUNG CANCERS AND LUNG METASTASES OF OTHER TUMORS.

D. Kandioler, G. Dekan, A. End, E. Paschinga, H. Buchmayer, M. Gnant, F. Langmann, C. Mannhalter, F. Eckersberger, and E. Wolner (1996)
J. Thorac. Cardiovasc. Surg. 111, 827-832
 |  Abstract »  |  Full Text »

Mechanisms of Toxicity and Carcinogenesis.

B. F. Trump (1995)
Toxicol Pathol 23, 775-827
 |  PDF »

Regulation of the Sequence-specific DNA Binding Function of p53 by Protein Kinase C and Protein Phosphatases.

I. Takenaka, F. Morin, B. R. Seizinger, and N. Kley (1995)
J. Biol. Chem. 270, 5405-5411
 |  Abstract »  |  Full Text »  |  PDF »

p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60.

C. Thut, J. Chen, R Klemm, and R Tjian (1995)
Science 267, 100-104
 |  Abstract »  |  PDF »

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations.

Y Cho, S Gorina, P. Jeffrey, and N. Pavletich (1994)
Science 265, 346-355
 |  Abstract »  |  PDF »

High-resolution structure of the oligomerization domain of p53 by multidimensional NMR.

G. Clore, J. Omichinski, K Sakaguchi, N Zambrano, H Sakamoto, E Appella, and A. Gronenborn (1994)
Science 265, 386-391
 |  Abstract »  |  PDF »

Identification of p53 Mutations in Endometrial Adenocarcinoma by Polymerase Chain Reaction-Single-Strand Conformation Polymorphism.

S. S. Wachtel, G. Wachtel, L. P. Shulman, O. Phillips, B. Miller, and G. Photopulos (1994)
Reproductive Sciences 1, 234-237
 |  Abstract »  |  PDF »

A cell cycle regulator potentially involved in genesis of many tumor types.

A Kamb, N. Gruis, J Weaver-Feldhaus, Q Liu, K Harshman, S. Tavtigian, E Stockert, R. Day 3rd, B. Johnson, and M. Skolnick (1994)
Science 264, 436-440
 |  Abstract »  |  PDF »

To Advertise   |   Find Products