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Science 18 September 1981:
Vol. 213. no. 4514, pp. 1394 - 1397
DOI: 10.1126/science.6267699
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Articles

Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin

W Vale, J Spiess, C Rivier, and J Rivier

No abstract or summary view of this item is available. To view the full-text version, follow this link.

Article topics:

  • Medicine..Behavioral and Psychosocial Issues


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M. O. Huising, J. M. Vaughan, S. H. Shah, K. L. Grillot, C. J. Donaldson, J. Rivier, G. Flik, and W. W. Vale (2008)
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Dopamine and Corticotropin-Releasing Factor Synergistically Alter Basolateral Amygdala-to-Medial Prefrontal Cortex Synaptic Transmission: Functional Switch after Chronic Cocaine Administration.
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Recent Findings in the Pathophysiology of Depression.
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Stress-Induced Intracellular Trafficking of Corticotropin-Releasing Factor Receptors in Rat Locus Coeruleus Neurons.
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Role of Ca2+-Independent Phospholipase A2 and Store-Operated Pathway in Urocortin-Induced Vasodilatation of Rat Coronary Artery.
T. Smani, A. Dominguez-Rodriguez, A. Hmadcha, E. Calderon-Sanchez, A. Horrillo-Ledesma, and A. Ordonez (2007)
Circ. Res. 101, 1194-1203
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Identifying Early Behavioral and Molecular Markers of Future Stress Sensitivity.
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Endocrinology 148, 4585-4591
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Impaired adaptation to repeated restraint and decreased response to cold in urocortin 1 knockout mice.
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Acute stress increases interstitial fluid amyloid-beta via corticotropin-releasing factor and neuronal activity.
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M. O Huising, L. M van der Aa, J. R Metz, A. de Fatima Mazon, B M L. V.-v. Kemenade, and G. Flik (2007)
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Expression of molecular equivalent of hypothalamic-pituitary-adrenal axis in adult retinal pigment epithelium.
M. A Zmijewski, R. K Sharma, and A. T Slominski (2007)
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Gastric Vagal Efferent Inhibition Evoked by Intravenous CRF Is Unrelated to Simultaneously Recorded Vagal Afferent Activity in Urethane-Anesthetized Rats.
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J Neurophysiol 97, 3004-3014
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Estrogen potentiates adrenocortical responses to stress in female rats.
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Am J Physiol Endocrinol Metab 292, E1173-E1182
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Structure of the N-terminal domain of a type B1 G protein-coupled receptor in complex with a peptide ligand.
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PNAS 104, 4858-4863
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Strain-specific steroidal control of pituitary function.
S.-N. Lee, B. Peng, R. Desjardins, J. E Pintar, R. Day, and I. Lindberg (2007)
J. Endocrinol. 192, 515-525
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Dehydration-induced drinking decreases Fos expression in hypothalamic paraventricular neurons expressing vasopressin but not corticotropin-releasing hormone.
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Endocrinology 148, 647-659
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Ectopic ACTH syndrome: our experience with 25 cases..
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Corticotropin-Releasing Factor within the Central Nucleus of the Amygdala Mediates Enhanced Ethanol Self-Administration in Withdrawn, Ethanol-Dependent Rats..
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Corticotropin-releasing hormone physiology.
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Corticotropin-releasing hormone receptor antagonists.
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Eur. J. Endocrinol. 155, S85-S91
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The role of corticotrophin-releasing hormone in the diagnosis of Cushing's syndrome.
C J Peters, H L Storr, A B Grossman, and M O Savage (2006)
Eur. J. Endocrinol. 155, S93-S98
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Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle.
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Corticotropin-releasing factor and its receptors in the brain of rats with insulin and corticosterone deficits..
Q. Huang, E. Timofeeva, and D. Richard (2006)
J. Mol. Endocrinol. 37, 213-226
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Regulation of corticotropin-releasing factor and its types 1 and 2 receptors by leptin in rats subjected to treadmill running-induced stress..
Q. Huang, E. Timofeeva, and D. Richard (2006)
J. Endocrinol. 191, 179-188
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Characterization of a Ultraviolet B-Induced Corticotropin-Releasing Hormone-Proopiomelanocortin System in Human Melanocytes.
B. Zbytek, J. Wortsman, and A. Slominski (2006)
Mol. Endocrinol. 20, 2539-2547
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Urocortin 3 Modulates the Neuroendocrine Stress Response and Is Regulated in Rat Amygdala and Hypothalamus by Stress and Glucocorticoids.
P. M. Jamieson, C. Li, C. Kukura, J. Vaughan, and W. Vale (2006)
Endocrinology 147, 4578-4588
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The Effect of Lateral Septum Corticotropin-Releasing Factor Receptor 2 Activation on Anxiety Is Modulated by Stress.
B. Henry, W. Vale, and A. Markou (2006)
J. Neurosci. 26, 9142-9152
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Urocortin Induces Interleukin-6 Gene Expression via Cyclooxygenase-2 Activity in Aortic Smooth Muscle Cells.
K. Kageyama, K. Hanada, T. Nigawara, T. Moriyama, K. Terui, S. Sakihara, and T. Suda (2006)
Endocrinology 147, 4454-4462
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Endocrinology: the next 60 years..
W. S Dhillo, K. G Murphy, and S. Bloom (2006)
J. Endocrinol. 190, 7-10
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Oxytocin actions within the supraoptic and paraventricular nuclei: differential effects on peripheral and intranuclear vasopressin release.
I. D. Neumann, L. Torner, N. Toschi, and A. H. Veenema (2006)
Am J Physiol Regulatory Integrative Comp Physiol 291, R29-R36
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Stress and the colon: central-vagal or direct peripheral effect of CRF?.
R. C. Rogers, G. E. Hermann, and R. A. Travagli (2006)
Am J Physiol Regulatory Integrative Comp Physiol 290, R1535-R1536
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Impact of state of arousal and stress neuropeptides on urodynamic function in freely moving rats.
D. A. Kiddoo, R. J. Valentino, S. Zderic, A. Ganesh, S. C. Leiser, L. Hale, and D. E. Grigoriadis (2006)
Am J Physiol Regulatory Integrative Comp Physiol 290, R1697-R1706
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Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior..
A. Chen, E. Zorrilla, S. Smith, D. Rousso, C. Levy, J. Vaughan, C. Donaldson, A. Roberts, K.-F. Lee, and W. Vale (2006)
J. Neurosci. 26, 5500-5510
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The Molecular Mechanisms Underlying the Regulation of the Biological Activity of Corticotropin-Releasing Hormone Receptors: Implications for Physiology and Pathophysiology.
E. W. Hillhouse and D. K. Grammatopoulos (2006)
Endocr. Rev. 27, 260-286
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Dynamic Expression and Regulation of the Corticotropin-Releasing Hormone/Urocortin-Receptor-Binding Protein System in the Primate Ovary during the Menstrual Cycle.
J. Xu, J. D. Hennebold, and R. L. Stouffer (2006)
J. Clin. Endocrinol. Metab. 91, 1544-1553
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Can modulating corticotropin releasing hormone receptors alter visceral sensitivity?.
S Fukudo, K Saito, Y Sagami, and M Kanazawa (2006)
Gut 55, 146-148
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Urocortin II enhances contractility in rabbit ventricular myocytes via CRF2 receptor-mediated stimulation of protein kinase A.
L.-Z. Yang, J. Kockskamper, F. R. Heinzel, M. Hauber, S. Walther, J. Spiess, and B. Pieske (2006)
Cardiovasc Res 69, 402-411
   Abstract »    Full Text »    PDF »
G Protein-Coupled Receptor Kinase 2 Involvement in Desensitization of Corticotropin-Releasing Factor (CRF) Receptor Type 1 by CRF in Murine Corticotrophs.
K. Kageyama, K. Hanada, T. Moriyama, T. Nigawara, S. Sakihara, and T. Suda (2006)
Endocrinology 147, 441-450
   Abstract »    Full Text »    PDF »
Urocortins of the South African Clawed Frog, Xenopus laevis: Conservation of Structure and Function in Tetrapod Evolution.
G. C. Boorse, E. J. Crespi, F. M. Dautzenberg, and R. J. Denver (2005)
Endocrinology 146, 4851-4860
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Corticotropin-releasing hormone effects on human pregnant vs. nonpregnant myometrium explants estimated from a mathematical model of uterine contraction.
T.-M. Mignot, B. Paris, B. Carbonne, C. Vauge, F. Ferre, and D. Vaiman (2005)
J Appl Physiol 99, 1157-1163
   Abstract »    Full Text »    PDF »
Corticotrophin-Releasing Factor Augments the IH in Rat Hypothalamic Paraventricular Nucleus Parvocellular Neurons In Vitro.
D.-L. Qiu, C.-P. Chu, T. Shirasaka, H. Tsukino, H. Nakao, K. Kato, T. Kunitake, T. Katoh, and H. Kannan (2005)
J Neurophysiol 94, 226-234
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Origin of Cocaine- and Amphetamine-Regulated Transcript-Containing Axons Innervating Hypophysiotropic Corticotropin-Releasing Hormone-Synthesizing Neurons in the Rat.
G. Wittmann, Z. Liposits, R. M. Lechan, and C. Fekete (2005)
Endocrinology 146, 2985-2991
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Expression and effects of metabotropic CRF1 and CRF2 receptors in rat small intestine.
C. Porcher, A. Juhem, A. Peinnequin, V. Sinniger, and B. Bonaz (2005)
Am J Physiol Gastrointest Liver Physiol 288, G1091-G1103
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Hypercortisolemia and Depression.
C. F. Gillespie and C. B. Nemeroff (2005)
Psychosom Med 67, S26-S28
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Distinct Conformations of the Corticotropin Releasing Factor Type 1 Receptor Adopted following Agonist and Antagonist Binding Are Differentially Regulated.
S. J. Perry, S. Junger, T. A. Kohout, S. R. J. Hoare, R. S. Struthers, D. E. Grigoriadis, and R. A. Maki (2005)
J. Biol. Chem. 280, 11560-11568
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Corticotropin-Releasing Factor Receptor 1 and Central Heart Rate Regulation in Mice during Expression of Conditioned Fear.
O. Stiedl, M. Meyer, O. Jahn, S. O. Ogren, and J. Spiess (2005)
J. Pharmacol. Exp. Ther. 312, 905-916
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Discovery of LH-regulated genes in the primate corpus luteum.
J. Xu, R.L. Stouffer, R.P. Searles, and J.D. Hennebold (2005)
Mol. Hum. Reprod. 11, 151-159
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Urocortin-induced relaxation in the human internal mammary artery.
Z.-W. Chen, Y. Huang, Q. Yang, X. Li, W. Wei, and G.-W. He (2005)
Cardiovasc Res 65, 913-920
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A soluble mouse brain splice variant of type 2{alpha} corticotropin-releasing factor (CRF) receptor binds ligands and modulates their activity.
A. M. Chen, M. H. Perrin, M. R. DiGruccio, J. M. Vaughan, B. K. Brar, C. M. Arias, K. A. Lewis, J. E. Rivier, P. E. Sawchenko, and W. W. Vale (2005)
PNAS 102, 2620-2625
   Abstract »    Full Text »    PDF »
Mouse Corticotropin-Releasing Factor Receptor Type 2{alpha} Gene: Isolation, Distribution, Pharmacological Characterization and Regulation by Stress and Glucocorticoids.
A. Chen, M. Perrin, B. Brar, C. Li, P. Jamieson, M. DiGruccio, K. Lewis, and W. Vale (2005)
Mol. Endocrinol. 19, 441-458
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Hypothalamic hormones a.k.a. hypothalamic releasing factors.
R. Guillemin (2005)
J. Endocrinol. 184, 11-28
   Abstract »    Full Text »    PDF »
Regional Hemodynamic Actions of Selective Corticotropin-Releasing Factor Type 2 Receptor Ligands in Conscious Rats.
S. M. Gardiner, J. E. March, P. A. Kemp, A. P. Davenport, K. E. Wiley, and T. Bennett (2005)
J. Pharmacol. Exp. Ther. 312, 53-60
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Role of Corticotropin-Releasing Factor Receptor-2 in Stress-Induced Suppression of Pulsatile Luteinizing Hormone Secretion in the Rat.
X. F. Li, J. E. Bowe, S. L. Lightman, and K. T. O'Byrne (2005)
Endocrinology 146, 318-322
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Calcium/calmodulin kinase IV pathway is involved in the transcriptional regulation of the corticotropin-releasing hormone gene promoter in neuronal cells.
E Yamamori, M Asai, M Yoshida, K Takano, K Itoi, Y Oiso, and Y Iwasaki (2004)
J. Mol. Endocrinol. 33, 639-649
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Stress and dysmenorrhoea: a population based prospective study.
L Wang, X Wang, W Wang, C Chen, A G Ronnennberg, W Guang, A Huang, Z Fang, T Zang, L Wang, et al. (2004)
Occup. Environ. Med. 61, 1021-1026
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Coexpression of Corticotropin-Releasing Hormone and Urotensin I Precursor Genes in the Caudal Neurosecretory System of the Euryhaline Flounder (Platichthys flesus): A Possible Shared Role in Peripheral Regulation.
W. Lu, L. Dow, S. Gumusgoz, M. J. Brierley, J. M. Warne, C. R. McCrohan, R. J. Balment, and D. Riccardi (2004)
Endocrinology 145, 5786-5797
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Estrogen Receptor (ER){beta} Isoforms Rather Than ER{alpha} Regulate Corticotropin-Releasing Hormone Promoter Activity through an Alternate Pathway.
W. J. S. Miller, S. Suzuki, L. K. Miller, R. Handa, and R. M. Uht (2004)
J. Neurosci. 24, 10628-10635
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Tissue plasminogen activator promotes the effects of corticotropin-releasing factor on the amygdala and anxiety-like behavior.
T. Matys, R. Pawlak, E. Matys, C. Pavlides, B. S. McEwen, and S. Strickland (2004)
PNAS 101, 16345-16350
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Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus.
Y. Chen, R. A. Bender, K. L. Brunson, J. K. Pomper, D. E. Grigoriadis, W. Wurst, and T. Z. Baram (2004)
PNAS 101, 15782-15787
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Cocaine- and Amphetamine-Regulated Transcript Activates the Hypothalamic-Pituitary-Adrenal Axis through a Corticotropin-Releasing Factor Receptor-Dependent Mechanism.
S. M. Smith, J. M. Vaughan, C. J. Donaldson, J. Rivier, C. Li, A. Chen, and W. W. Vale (2004)
Endocrinology 145, 5202-5209
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Prenatal Exposure to Interleukin-6 Results in Hypertension and Increased Hypothalamic-Pituitary-Adrenal Axis Activity in Adult Rats.
A.-M. Samuelsson, I. Ohrn, J. Dahlgren, E. Eriksson, B. Angelin, B. Folkow, and A. Holmang (2004)
Endocrinology 145, 4897-4911
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Corticotropin-Releasing Hormone Directly Activates Noradrenergic Neurons of the Locus Ceruleus Recorded In Vitro.
H. P. Jedema and A. A. Grace (2004)
J. Neurosci. 24, 9703-9713
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Neuronal activity and CRF receptor gene transcription in the brains of rats with colitis.
C. Porcher, V. Sinniger, A. Juhem, P. Mouchet, and B. Bonaz (2004)
Am J Physiol Gastrointest Liver Physiol 287, G803-G814
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Regulation of the Coupling to Different G Proteins of Rat Corticotropin-releasing Factor Receptor Type 1 in Human Embryonic Kidney 293 Cells.
D. Wietfeld, N. Heinrich, J. Furkert, K. Fechner, M. Beyermann, M. Bienert, and H. Berger (2004)
J. Biol. Chem. 279, 38386-38394
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Human Urocortin 2, a Corticotropin-Releasing Factor (CRF)2 Agonist, and Ovine CRF, a CRF1 Agonist, Differentially Alter Feeding and Motor Activity.
E. P. Zorrilla, L. E. Reinhardt, G. R. Valdez, K. Inoue, J. E. Rivier, W. W. Vale, and G. F. Koob (2004)
J. Pharmacol. Exp. Ther. 310, 1027-1034
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Hexa-histidin tag position influences disulfide structure but not binding behavior of in vitro folded N-terminal domain of rat corticotropin-releasing factor receptor type 2a.
J. Klose, N. Wendt, S. Kubald, E. Krause, K. Fechner, M. Beyermann, M. Bienert, R. Rudolph, and S. Rothemund (2004)
Protein Sci. 13, 2470-2475
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NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor.
C. R. R. Grace, M. H. Perrin, M. R. DiGruccio, C. L. Miller, J. E. Rivier, W. W. Vale, and R. Riek (2004)
PNAS 101, 12836-12841
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Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques.
C. S. Barr, T. K. Newman, M. Schwandt, C. Shannon, R. L. Dvoskin, S. G. Lindell, J. Taubman, B. Thompson, M. Champoux, K. P. Lesch, et al. (2004)
PNAS 101, 12358-12363
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Promoter Analysis of Human Corticotropin-Releasing Factor (CRF) Type 1 Receptor and Regulation by CRF and Urocortin.
K. L. Parham, S. Zervou, E. Karteris, R. D. Catalano, R. W. Old, and E. W. Hillhouse (2004)
Endocrinology 145, 3971-3983
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Corticotropin-Releasing Factor Receptors CRF1 and CRF2 Exert Both Additive and Opposing Influences on Defensive Startle Behavior.
V. B. Risbrough, R. L. Hauger, A. L. Roberts, W. W. Vale, and M. A. Geyer (2004)
J. Neurosci. 24, 6545-6552
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Effect of a corticotropin releasing hormone receptor antagonist on colonic sensory and motor function in patients with irritable bowel syndrome.
Y Sagami, Y Shimada, J Tayama, T Nomura, M Satake, Y Endo, T Shoji, K Karahashi, M Hongo, and S Fukudo (2004)
Gut 53, 958-964
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Cortagine, a specific agonist of corticotropin-releasing factor receptor subtype 1, is anxiogenic and antidepressive in the mouse model.
H. Tezval, O. Jahn, C. Todorovic, A. Sasse, K. Eckart, and J. Spiess (2004)
PNAS 101, 9468-9473
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Estrogen Receptor-Mediated Down-Regulation of Corticotropin-Releasing Hormone Gene Expression Is Dependent on a Cyclic Adenosine 3',5'-Monophosphate Regulatory Element in Human Placental Syncytiotrophoblast Cells.
X. Ni, Y. Hou, B. R. King, X. Tang, M. A. Read, R. Smith, and R. C. Nicholson (2004)
J. Clin. Endocrinol. Metab. 89, 2312-2318
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Urocortin II Gene Is Highly Expressed in Mouse Skin and Skeletal Muscle Tissues: Localization, Basal Expression in Corticotropin-Releasing Factor Receptor (CRFR) 1- and CRFR2-Null Mice, and Regulation by Glucocorticoids.
A. Chen, A. Blount, J. Vaughan, B. Brar, and W. Vale (2004)
Endocrinology 145, 2445-2457
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Corticotropin-Releasing Factor and Urocortin I Modulate Excitatory Glutamatergic Synaptic Transmission.
J. Liu, B. Yu, V. Neugebauer, D. E. Grigoriadis, J. Rivier, W. W. Vale, P. Shinnick-Gallagher, and J. P. Gallagher (2004)
J. Neurosci. 24, 4020-4029
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Corticotrophin Releasing Factor-Induced Synaptic Plasticity in the Amygdala Translates Stress into Emotional Disorders.
D. G. Rainnie, R. Bergeron, T. J. Sajdyk, M. Patil, D. R. Gehlert, and A. Shekhar (2004)
J. Neurosci. 24, 3471-3479
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Specificity and Regulation of Extracellularly Regulated Kinase1/2 Phosphorylation through Corticotropin-Releasing Factor (CRF) Receptors 1 and 2{beta} by the CRF/Urocortin Family of Peptides.
B. K. Brar, A. Chen, M. H. Perrin, and W. Vale (2004)
Endocrinology 145, 1718-1729
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Stress and the genesis of diabetes mellitus in schizophrenia.
T. G. Dinan (2004)
The British Journal of Psychiatry 184, s72-s75
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NF-{kappa}B Participates in the Corticotropin-releasing, Hormone-induced Regulation of the Pituitary Proopiomelanocortin Gene.
K. P. K