Science 25 July 1969: Vol. 165. no. 3891, pp. 349 - 357 DOI: 10.1126/science.165.3891.349

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Articles

microRNA miR-196a-2 and Breast Cancer: A Genetic and Epigenetic Association Study and Functional Analysis.

A. E. Hoffman, T. Zheng, C. Yi, D. Leaderer, J. Weidhaas, F. Slack, Y. Zhang, T. Paranjape, and Y. Zhu (2009)
Cancer Res. 69, 5970-5977
 |  Abstract »  |  Full Text »  |  PDF »

The discovery of eukaryotic genome design and its forgotten corollary--the postulate of gene regulation by nuclear RNA.

T. Pederson (2009)
FASEB J 23, 2019-2021
 |  Abstract »  |  Full Text »  |  PDF »

Evolution of the Vertebrate Gene Regulatory Network Controlled by the Transcriptional Repressor REST.

R. Johnson, J. Samuel, C. K. L. Ng, R. Jauch, L. W. Stanton, and I. C. Wood (2009)
Mol. Biol. Evol. 26, 1491-1507
 |  Abstract »  |  Full Text »  |  PDF »

Colloquium Papers: Adaptive radiations: From field to genomic studies.

S. A. Hodges and N. J. Derieg (2009)
PNAS 106, 9947-9954
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Regulation of Storage Protein Synthesis During Dicotyledon Seed Filling.

J. Verdier and R. D. Thompson (2008)
Plant Cell Physiol. 49, 1263-1271
 |  Abstract »  |  Full Text »  |  PDF »

MicroRNAs: components of an integrated system controlling cardiac development, physiology, and disease pathogenesis.

G. Condorelli and S. Dimmeler (2008)
Cardiovasc Res 79, 551-552
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Gene regulatory networks and embryonic specification.

L. Hood (2008)
PNAS 105, 5951-5952
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Possible involvement of SINEs in mammalian-specific brain formation.

T. Sasaki, H. Nishihara, M. Hirakawa, K. Fujimura, M. Tanaka, N. Kokubo, C. Kimura-Yoshida, I. Matsuo, K. Sumiyama, N. Saitou, et al. (2008)
PNAS 105, 4220-4225
 |  Abstract »  |  Full Text »  |  PDF »

mef2 activity levels differentially affect gene expression during Drosophila muscle development.

S. J. Elgar, J. Han, and M. V. Taylor (2008)
PNAS 105, 918-923
 |  Abstract »  |  Full Text »  |  PDF »

Purifying Selection Maintains Highly Conserved Noncoding Sequences in Drosophila.

S. Casillas, A. Barbadilla, and C. M. Bergman (2007)
Mol. Biol. Evol. 24, 2222-2234
 |  Abstract »  |  Full Text »  |  PDF »

Raising the estimate of functional human sequences.

M. Pheasant and J. S. Mattick (2007)
Genome Res. 17, 1245-1253
 |  Abstract »  |  Full Text »  |  PDF »

A generative bias towards average complexity in artificial cell lineages.

R. Lohaus, N. L Geard, J. Wiles, and R. B.R Azevedo (2007)
Proc R Soc B 274, 1741-1751
 |  Abstract »  |  Full Text »  |  PDF »

MYBS: a comprehensive web server for mining transcription factor binding sites in yeast.

H.-K. Tsai, M.-Y. Chou, C.-H. Shih, G. T.-W. Huang, T.-H. Chang, and W.-H. Li (2007)
Nucleic Acids Res. 35, W221-W226
 |  Abstract »  |  Full Text »  |  PDF »

RNA Maps Reveal New RNA Classes and a Possible Function for Pervasive Transcription.

P. Kapranov, J. Cheng, S. Dike, D. A. Nix, R. Duttagupta, A. T. Willingham, P. F. Stadler, J. Hertel, J. Hackermuller, I. L. Hofacker, et al. (2007)
Science 316, 1484-1488
 |  Abstract »  |  Full Text »  |  PDF »

Colloquium Papers: Between "design" and "bricolage": Genetic networks, levels of selection, and adaptive evolution.

A. S. Wilkins (2007)
PNAS 104, 8590-8596
 |  Abstract »  |  Full Text »  |  PDF »

From the Academy: Colloquium Perspective: In the light of evolution I: Adaptation and complex design.

J. C. Avise and F. J. Ayala (2007)
PNAS 104, 8563-8566
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A new paradigm for developmental biology.

J. S. Mattick (2007)
J. Exp. Biol. 210, 1526-1547
 |  Abstract »  |  Full Text »  |  PDF »

Variable gene expression in eukaryotes: a network perspective.

P. J. Wittkopp (2007)
J. Exp. Biol. 210, 1567-1575
 |  Abstract »  |  Full Text »  |  PDF »

Coregulators: From Whence Came These "Master Genes".

B. W. O'Malley (2007)
Mol. Endocrinol. 21, 1009-1013
 |  Abstract »  |  Full Text »  |  PDF »

Small dsRNAs induce transcriptional activation in human cells.

L.-C. Li, S. T. Okino, H. Zhao, D. Pookot, R. F. Place, S. Urakami, H. Enokida, and R. Dahiya (2006)
PNAS 103, 17337-17342
 |  Abstract »  |  Full Text »  |  PDF »

Ribo-gnome: The Big World of Small RNAs.

P. D. Zamore and B. Haley (2005)
Science 309, 1519-1524
 |  Abstract »  |  Full Text »  |  PDF »

Disparity, adaptation, exaptation, bookkeeping, and contingency at the genome level.

J. Brosius (2005)
Paleobiology 31, 1-16
 |  Abstract »  |  Full Text »  |  PDF »

Meeting Report: The Future and Limits of Systems Biology.

E. Werner (2005)
Sci. STKE 2005, pe16
 |  Abstract »  |  Full Text »  |  PDF »

Comparative Methods for the Analysis of Gene-Expression Evolution: An Example Using Yeast Functional Genomic Data.

T. H. Oakley, Z. Gu, E. Abouheif, N. H. Patel, and W.-H. Li (2005)
Mol. Biol. Evol. 22, 40-50
 |  Abstract »  |  Full Text »  |  PDF »

Conservation and Coevolution in the Scale-Free Human Gene Coexpression Network.

I. K. Jordan, L. Marino-Ramirez, Y. I. Wolf, and E. V. Koonin (2004)
Mol. Biol. Evol. 21, 2058-2070
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Similarities, Dissimilarities, and Conservation of cis-Elements in Duplicated Genes of Arabidopsis.

G. Haberer, T. Hindemitt, B. C. Meyers, and K. F.X. Mayer (2004)
Plant Physiology 136, 3009-3022
 |  Abstract »  |  Full Text »  |  PDF »

RNA Interference and mRNA Silencing, 2004: How Far Will They Reach?.

T. Pederson (2004)
Mol. Biol. Cell 15, 407-410
 |  Abstract »  |  Full Text »  |  PDF »

The Evolution of Transcriptional Regulation in Eukaryotes.

G. A. Wray, M. W. Hahn, E. Abouheif, J. P. Balhoff, M. Pizer, M. V. Rockman, and L. A. Romano (2003)
Mol. Biol. Evol. 20, 1377-1419
 |  Abstract »  |  Full Text »  |  PDF »

Hairpin RNAs and Retrotransposon LTRs Effect RNAi and Chromatin-Based Gene Silencing.

V. Schramke and R. Allshire (2003)
Science 301, 1069-1074
 |  Abstract »  |  Full Text »  |  PDF »

Rapid evolution of male-biased gene expression in Drosophila.

C. D. Meiklejohn, J. Parsch, J. M. Ranz, and D. L. Hartl (2003)
PNAS 100, 9894-9899
 |  Abstract »  |  Full Text »  |  PDF »

Convergent evolution of perenniality in rice and sorghum.

F. Y. Hu, D. Y. Tao, E. Sacks, B. Y. Fu, P. Xu, J. Li, Y. Yang, K. McNally, G. S. Khush, A. H. Paterson, et al. (2003)
PNAS 100, 4050-4054
 |  Abstract »  |  Full Text »  |  PDF »

Abundant Raw Material for Cis-Regulatory Evolution in Humans.

M. V. Rockman and G. A. Wray (2002)
Mol. Biol. Evol. 19, 1991-2004
 |  Abstract »  |  Full Text »  |  PDF »

Exploring genetic regulatory networks in metazoan development: methods and models.

M. S. Halfon and A. M. Michelson (2002)
Physiol Genomics 10, 131-143
 |  Abstract »  |  Full Text »  |  PDF »

Evolution of a Polymorphic Regulatory Element in Interferon-{gamma} Through Transposition and Mutation.

H. Ackerman, I. Udalova, J. Hull, and D. Kwiatkowski (2002)
Mol. Biol. Evol. 19, 884-890
 |  Abstract »  |  Full Text »  |  PDF »

Review ArticleThe Evolution of Controlled Multitasked Gene Networks: The Role of Introns and Other Noncoding RNAs in the Development of Complex Organisms.

J. S. Mattick and M. J. Gagen (2001)
Mol. Biol. Evol. 18, 1611-1630
 |  Abstract »  |  Full Text »  |  PDF »

Adaptive variation in lactate dehydrogenase-B gene expression: Role of a stress-responsive regulatory element.

P. M. Schulte, H. C. Glemet, A. A. Fiebig, and D. A. Powers (2000)
PNAS 97, 6597-6602
 |  Abstract »  |  Full Text »  |  PDF »

Special Feature: Evolution of biological complexity.

C. Adami, C. Ofria, and T. C. Collier (2000)
PNAS 97, 4463-4468
 |  Abstract »  |  Full Text »  |  PDF »

KAP-1 Corepressor Protein Interacts and Colocalizes with Heterochromatic and Euchromatic HP1 Proteins: a Potential Role for Kruppel-Associated Box-Zinc Finger Proteins in Heterochromatin-Mediated Gene Silencing.

R. F. Ryan, D. C. Schultz, K. Ayyanathan, P. B. Singh, J. R. Friedman, W. J. Fredericks, and F. J. Rauscher III (1999)
Mol. Cell. Biol. 19, 4366-4378
 |  Abstract »  |  Full Text »  |  PDF »

Genes and Chromomeres: A Puzzle in Three Dimensions.

B. H. Judd (1998)
Genetics 150, 1-9
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Transcriptional Regulators and the Evolution of Plant Form.

J. Doebley and L. Lukens (1998)
PLANT CELL 10, 1075-1082
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Three novel families of miniature inverted-repeat transposable elements are associated with genes of the yellow fever mosquito, Aedes aegypti.

Z. Tu (1997)
PNAS 94, 7475-7480
 |  Abstract »  |  Full Text »  |  PDF »

The hardwiring of development: organization and function of genomic regulatory systems.

M. Arnone and E. Davidson (1997)
Development 124, 1851-1864
 |  Abstract »  |  PDF »

An Alu Element in the Myeloperoxidase Promoter Contains a Composite SP1-Thyroid Hormone-Retinoic Acid Response Element.

F. J. Piedrafita, R. B. Molander, G. Vansant, E. A. Orlova, M. Pfahl, and W. F. Reynolds (1996)
J. Biol. Chem. 271, 14412-14420
 |  Abstract »  |  Full Text »  |  PDF »

A Haploid Expressed Gene Cluster Exists as a Single Chromatin Domain in Human Sperm.

S. K. Choudhary, S. M. Wykes, J. A. Kramer, A. N. Mohamed, F. Koppitch, J. E. Nelson, and , a. S. A. Krawetz (1995)
J. Biol. Chem. 270, 8755-8762
 |  Abstract »  |  Full Text »  |  PDF »

Intersecting batteries of differentially expressed genes in the early sea urchin embryo..

P Thiebaud, M Goodstein, F J Calzone, N Theze, R J Britten, and E H Davidson (1990)
Genes & Dev. 4, 1999-2010
 |  Abstract »  |  PDF »

Inhibition of DNA binding proteins by oligonucleotide-directed triple helix formation.

L. Maher 3rd, B Wold, and P. Dervan (1989)
Science 245, 725-730
 |  Abstract »  |  PDF »

Site-specific oligonucleotide binding represses transcription of the human c-myc gene in vitro.

M Cooney, G Czernuszewicz, E. Postel, S. Flint, and M. Hogan (1988)
Science 241, 456-459
 |  Abstract »  |  PDF »

The Human Genome and Its Evolutionary Context.

G. Bernardi and G. Bernardi (1986)
Cold Spring Harb Symp Quant Biol 51, 479-487
 |  Abstract »  |  PDF »

Lineage-specific Gene Expression in the Sea Urchin Embryo.

E.H. Davidson, C.N. Flytzanis, J.J. Lee, J.J. Robinson, S.J. Rose III, and H.M. Sucov (1985)
Cold Spring Harb Symp Quant Biol 50, 321-328
 |  Abstract »  |  PDF »

Control of neuronal gene expression.

J. Sutcliffe, R. Milner, J. Gottesfeld, and W Reynolds (1984)
Science 225, 1308-1315
 |  Abstract »  |  PDF »

Replication timing of genes and middle repetitive sequences.

M. Goldman, G. Holmquist, M. Gray, L. Caston, and A Nag (1984)
Science 224, 686-692
 |  Abstract »  |  PDF »

Gene expression in eukaryotes.

D. Brown (1981)
Science 211, 667-674
 |  Abstract »  |  PDF »

Genes Are Things You Have Whether You Want Them or Not.

C. Sapienza and W. F. Doolittle (1981)
Cold Spring Harb Symp Quant Biol 45, 177-182
 |  Abstract »  |  PDF »

Regulation of gene expression: possible role of repetitive sequences.

E. Davidson and R. Britten (1979)
Science 204, 1052-1059
 |  Abstract »  |  PDF »

Plasmid DNA Replication: RK2- and R6K-encoded Trans-acting Factors and Their Sites of Action.

R. Kolter, M. Inuzuka, D. Figurski, C. Thomas, D. Stalker, and D. R. Helinski (1979)
Cold Spring Harb Symp Quant Biol 43, 91-97
 |  Abstract »  |  PDF »

Low repetitive DNA content in Aspergillus nidulans.

W. Timberlake (1978)
Science 202, 973-975
 |  Abstract »  |  PDF »

Purification of a Protein from Unfertilized Eggs of Drosophila with Specific Affinity for a Defined DNA Sequence and the Cloning of This DNA Sequence in Bacterial Plasmids.

H. Weideli, P. Schedl, S. Artavanis-Tsakonas, R. Steward, R. Yuan, and W. J. Gehring (1978)
Cold Spring Harb Symp Quant Biol 42, 693-700
 |  Abstract »  |  PDF »

Studies on the DNA Fragments of Mammals and Drosophila Containing Structural Genes and Adjacent Sequences.

Y. V. Ilyin, N. A. Tchurikov, E. V. Ananiev, A. P. Ryskov, G. N. Yenikolopov, S. A. Limborska, N. E. Maleeva, V. A. Gvozdev, and G. P. Georgiev (1978)
Cold Spring Harb Symp Quant Biol 42, 959-969
 |  Abstract »  |  PDF »

Physical Mapping of Repetitive DNA Sequences Neighboring the Rabbit {beta}-Globin Gene.

R. A. Flavell, A. J. Jeffreys, and G. C. Grosveld (1978)
Cold Spring Harb Symp Quant Biol 42, 1003-1010
 |  Abstract »  |  PDF »

Repeated Gene Families in Drosophila melanogaster.

D. J. Finnegan, G. M. Rubin, M. W. Young, and D. S. Hogness (1978)
Cold Spring Harb Symp Quant Biol 42, 1053-1063
 |  Abstract »  |  PDF »

Newly evolved repeated DNA sequences in primates.

D Gillespie (1977)
Science 196, 889-891
 |  Abstract »  |  PDF »

RNA processing and RNA tumor virus origin and evolution.

D Gillespie and R. Gallo (1975)
Science 188, 802-811
 |  Abstract »  |  PDF »

DNA modification mechanisms and gene activity during development.

R Holliday and J. Pugh (1975)
Science 187, 226-232
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Arrangement and Characterization of Repetitive Sequence Elements in Animal DNAs.

E. H. Davidson, D. E. Graham, B. R. Neufeld, M. E. Chamberlin, C. S. Amenson, B. R. Hough, and R. J. Britten (1974)
Cold Spring Harb Symp Quant Biol 38, 295-301
 |  Abstract »  |  PDF »

Organization and Transcription of DNA in Chromosomes and Mitochondria of Drosophila.

C. D. Laird, W. Y. Chooi, E. H. Cohen, E. Dickson, N. Hutchinson, and S. H. Turner (1974)
Cold Spring Harb Symp Quant Biol 38, 311-327
 |  Abstract »  |  PDF »

Cleavage of Mouse DNA by a Restriction Enzyme as a Clue to the Arrangement of Genes.

M. Botchan, G. McKenna, and P. A. Sharp (1974)
Cold Spring Harb Symp Quant Biol 38, 383-395
 |  Abstract »  |  PDF »

Repetitive DNA in Polytene Chromosomes of Drosophila melanogaster.

G. T. Rudkin and K. D. Tartof (1974)
Cold Spring Harb Symp Quant Biol 38, 397-403
 |  Abstract »  |  PDF »

An Examination of the One Cistron: One Chromomere Concept.

B. H. Judd and M. W. Young (1974)
Cold Spring Harb Symp Quant Biol 38, 573-579
 |  Abstract »  |  PDF »

Analysis of a Whole Chromosome in Drosophila.

B. Hochman (1974)
Cold Spring Harb Symp Quant Biol 38, 581-589
 |  Abstract »  |  PDF »

Genetic Organization and Regulation of the Drosophila Y Chromosome.

T. G. Sanders and G. B. Ayles (1974)
Cold Spring Harb Symp Quant Biol 38, 685-691
 |  Abstract »  |  PDF »

Transcription and Structure of the Genome of the Cellular Slime Mold Dictyostelium discoideum.

H. F. Lodish, R. A. Firtel, and A. Jacobson (1974)
Cold Spring Harb Symp Quant Biol 38, 899-914
 |  Abstract »  |  PDF »

Molecular Models and Combinatorial Principles in Cell Differentiation and Morphogenesis.

A. Gierer (1974)
Cold Spring Harb Symp Quant Biol 38, 951-961
 |  Abstract »  |  PDF »

The Organization of Genetic Material in Eukaryotes: Progress and Prospects.

H. Swift (1974)
Cold Spring Harb Symp Quant Biol 38, 963-979
 |  Abstract »  |  PDF »

Biogenesis of mRNA: Genetic Regulation in Mammalian Cells.

J. E. Darnell, W. R. Jelinek, and G. R. Molloy (1973)
Science 181, 1215-1221
 |  PDF »

The Development of a Molecular Model of Lung.

H. G. Boren (1970)
Arch Intern Med 126, 491-495
 |  Abstract »  |  PDF »

A Facultative Gymnosperm from an Interspecific Cotton Hybrid.

V. G. Meyer (1970)
Science 169, 886-888
 |  Abstract »  |  PDF »

Phage, Colicins, and Macroregulatory Phenomena.

S. E. Luria (1970)
Science 168, 1166-1170
 |  PDF »

Satellite DNA in Constitutive Heterochromatin of the Guinea Pig.

J. J. Yunis and W. G. Yasmineh (1970)
Science 168, 263-265
 |  Abstract »  |  PDF »

Induction of Glutamine Synthetase in Embryonic Retina: Its Dependence on Cell Interactions.

J. E. Morris and A. A. Moscona (1970)
Science 167, 1736-1738
 |  Abstract »  |  PDF »

A Prodromus to the Genetic Analysis of Puffing in Drosophila.

M. Ashburner (1970)
Cold Spring Harb Symp Quant Biol 35, 533-538
 |  Abstract »  |  PDF »

Nuclear and Cytoplasmic Messenger-like RNA and Their Relation to the Active Messenger RNA in Polyribosomes of HeLa Cells.

K. Scherrer, G. Spohr, N. Granboulan, C. Morel, J. Grosclaude, and C. Chezzi (1970)
Cold Spring Harb Symp Quant Biol 35, 539-554
 |  Abstract »  |  PDF »

Studies on the Relationship of mRNA to Heterogeneous Nuclear RNA in Mammalian Cells.

J. E. Darnell, G. N. Pagoulatos, U. Lindberg, and R. Balint (1970)
Cold Spring Harb Symp Quant Biol 35, 555-560
 |  Abstract »  |  PDF »

RNA Polymerase of Lymphoid Tissue: A Preliminary Characterization of the Enzyme and the RNA It Synthesizes.

J. J. Furth and G. E. Austin (1970)
Cold Spring Harb Symp Quant Biol 35, 641-648
 |  Abstract »  |  PDF »

Ectopic Polypeptide Hormone Production by Tumors.

G. S. OMENN (1970)
Ann Intern Med 72, 136-138
 |  Abstract »  |  PDF »

Control of specific gene expression in higher organisms. Expression of mammalian genes may be controlled by repressors acting on the translation of messenger RNA..

G. M. Tomkins, T. D. Gelehrter, D. Granner, D. Martin Jr., H. H. Samuels, and E. B. Thompson (1969)
Science 166, 1474-1480
 |  PDF »

Gene Regulation in Higher Cells.

C. H. Waddington (1969)
Science 166, 639-640
 |  PDF »

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