Science 25 November 1949: Vol. 110. no. 2865, pp. 543 - 548 DOI: 10.1126/science.110.2865.543

Table of Contents | Next

Articles

Allogeneic Hematopoietic Stem-Cell Transplantation for Sickle Cell Disease.

M. M. Hsieh, E. M. Kang, C. D. Fitzhugh, M. B. Link, C. D. Bolan, R. Kurlander, R. W. Childs, G. P. Rodgers, J. D. Powell, and J. F. Tisdale (2009)
N. Engl. J. Med. 361, 2309-2317
 |  Abstract »  |  Full Text »  |  PDF »

Medea and the Microtubule: Research Has Been Translational Ever Since Colchis.

G. Weissmann (2009)
FASEB J 23, 2791-2794
 |  Full Text »  |  PDF »

Colloquium Papers: In the light of directed evolution: Pathways of adaptive protein evolution.

J. D. Bloom and F. H. Arnold (2009)
PNAS 106, 9995-10000
 |  Abstract »  |  Full Text »  |  PDF »

A Novel High-Throughput Screening Assay for Sickle Cell Disease Drug Discovery.

E. Pais, J. S. Cambridge, C. S. Johnson, H. J. Meiselman, T. C. Fisher, and T. Alexy (2009)
J Biomol Screen 14, 330-336
 |  Abstract »  |  PDF »

Hemoglobin research and the origins of molecular medicine.

A. N. Schechter (2008)
Blood 112, 3927-3938
 |  Abstract »  |  Full Text »  |  PDF »

The biologistical construction of race: 'admixture' technology and the new genetic medicine..

D. Fullwiley (2008)
Social Studies of Science 38, 695-735
 |  Abstract »  |  PDF »

Genetic complexity in sickle cell disease.

D. R. Higgs and W. G. Wood (2008)
PNAS 105, 11595-11596
 |  Full Text »  |  PDF »

From Bioinformatics to Bioassays: Gleaning Insights into Protein Structure-Function from Disease-Associated nsSNPs.

J. L. Cmarik (2008)
Mol. Interv. 8, 162-164
 |  Abstract »  |  Full Text »  |  PDF »

Nitrite Reductase Activity of Hemoglobin S (Sickle) Provides Insight into Contributions of Heme Redox Potential Versus Ligand Affinity.

R. Grubina, S. Basu, M. Tiso, D. B. Kim-Shapiro, and M. T. Gladwin (2008)
J. Biol. Chem. 283, 3628-3638
 |  Abstract »  |  Full Text »  |  PDF »

Fifty-Eight Years of Hemoglobin Analysis.

S. O. Brennan (2008)
Clin. Chem. 54, 8-10
 |  Full Text »  |  PDF »

Mass Spectrometry: A Tool for Enhanced Detection of Hemoglobin Variants.

P. Kleinert, M. Schmid, K. Zurbriggen, O. Speer, M. Schmugge, B. Roschitzki, S. S. Durka, U. Leopold, T. Kuster, C. W. Heizmann, et al. (2008)
Clin. Chem. 54, 69-76
 |  Abstract »  |  Full Text »  |  PDF »

Sickle cell vasoocclusion and rescue in a microfluidic device.

J. M. Higgins, D. T. Eddington, S. N. Bhatia, and L. Mahadevan (2007)
PNAS 104, 20496-20500
 |  Abstract »  |  Full Text »  |  PDF »

Big Strokes in Small Persons.

R. J. Adams (2007)
Arch Neurol 64, 1567-1574
 |  Abstract »  |  Full Text »  |  PDF »

THAL for THAL?.

D. H. K. Chui (2007)
Blood 110, 2788-2789
 |  Full Text »  |  PDF »

Positive natural selection in the human lineage..

P. C. Sabeti, S. F. Schaffner, B. Fry, J. Lohmueller, P. Varilly, O. Shamovsky, A. Palma, T. S. Mikkelsen, D. Altshuler, and E. S. Lander (2006)
Science 312, 1614-1620
 |  Abstract »  |  Full Text »  |  PDF »

Anaesthesia for peculiar cells--a century of sickle cell disease.

P. G. Firth (2005)
Br. J. Anaesth. 95, 287-299
 |  Abstract »  |  Full Text »  |  PDF »

Ion Transport Pathology in the Mechanism of Sickle Cell Dehydration.

V. L. Lew and R. M. Bookchin (2005)
Physiol Rev 85, 179-200
 |  Abstract »  |  Full Text »  |  PDF »

Sickle-Cell Anemia Hemoglobin: The Molecular Biology of the First "Molecular Disease"--The Crucial Importance of Serendipity.

V. M. Ingram (2004)
Genetics 167, 1-7
 |  Full Text »  |  PDF »

Two Lessons From the Interface of Genetics and Medicine.

A. C. Allison (2004)
Genetics 166, 1591-1599
 |  Full Text »  |  PDF »

METABOLISM OF OPIOIDS IS ALTERED IN LIVER MICROSOMES OF SICKLE CELL TRANSGENIC MICE.

S. Nagar, R. P. Remmel, R. P. Hebbel, and C. L. Zimmerman (2004)
Drug Metab. Dispos. 32, 98-104
 |  Abstract »  |  Full Text »  |  PDF »

The First Sequence: Fred Sanger and Insulin.

A. O. W. Stretton (2002)
Genetics 162, 527-532
 |  Full Text »  |  PDF »

Primer on Medical Genomics Part I: History of Genetics and Sequencing of the Human Genome.

C. P. Lorentz, E. D. Wieben, A. Tefferi, D. A. H. Whiteman, and G. W. Dewald (2002)
Mayo Clin. Proc. 77, 773-782
 |  Abstract »  |  PDF »

The Challenge of Painful Crisis in Sickle Cell Disease.

R. L. Nagel (2001)
JAMA 286, 2152-2153
 |  Full Text »  |  PDF »

Sickle Cell Anemia.

G. J. Lonergan, D. B. Cline, and S. L. Abbondanzo (2001)
RadioGraphics 21, 971-994
 |  Abstract »  |  Full Text »  |  PDF »

The Acute Chest Syndrome of Sickle Cell Disease.

O. S. Platt (2000)
N. Engl. J. Med. 342, 1904-1907
 |  Full Text »

Blood: New designs for a new millennium.

K. Kaushansky (2000)
Blood 95, 1-6
 |  Full Text »  |  PDF »

Bone Marrow Transplantation for Non-Malignant Disease.

K. M. Sullivan, R. Parkman, and M. C. Walters (2000)
Hematology 2000, 319-338
 |  Abstract »  |  Full Text »  |  PDF »

Sickle Cell Acute Chest Syndrome: Pathogenesis and Rationale for Treatment.

M. J. Stuart and B.N. Y. Setty (1999)
Blood 94, 1555-1560
 |  Abstract »  |  Full Text »  |  PDF »

Detection of Nitrosyl Hemoglobin in Venous Blood in the Treatment of Sickle Cell Anemia with Hydroxyurea.

R. E. Glover, E. D. Ivy, E. P. Orringer, H. Maeda, and R. P. Mason (1999)
Mol. Pharmacol. 55, 1006-1010
 |  Abstract »  |  Full Text »

Cancer and Genetics: What We Need to Know Now.

K. Ruccione (1999)
Journal of Pediatric Oncology Nursing 16, 156-171
 |  Abstract »  |  PDF »

Transgenic knockout mice exclusively expressing human hemoglobin S after transfer of a 240-kb beta s-globin yeast artificial chromosome: A mouse model of sickle cell anemia.

J. C. Chang, R. Lu, C. Lin, S.-M. Xu, Y. W. Kan, S. Porcu, E. Carlson, M. Kitamura, S. Yang, L. Flebbe-Rehwaldt, et al. (1998)
PNAS 95, 14886-14890
 |  Abstract »  |  Full Text »  |  PDF »

An Electronic Database of Human Hemoglobin Variants on the World Wide Web.

D. H.K. Chui, R. Hardison, C. Riemer, W. Miller, M.F.H. Carver, T.P. Molchanova, G.D. Efremov, and T. H.J. Huisman (1998)
Blood 91, 2643-2644
 |  Full Text »  |  PDF »

A New Intellectual Framework for Psychiatry.

E. R. Kandel (1998)
Am J Psychiatry 155, 457-469
 |  Abstract »  |  Full Text »

Transgenic Knockout Mice with Exclusively Human Sickle Hemoglobin and Sickle Cell Disease.

C. Pászty, C. M. Brion, E. Manci, H. E. Witkowska, M. E. Stevens, N. Mohandas, and E. M. Rubin (1997)
Science 278, 876-878
 |  Abstract »  |  Full Text »

Pathogenesis and Treatment of Sickle Cell Disease.

H. F. Bunn (1997)
N. Engl. J. Med. 337, 762-769
 |  Full Text »  |  PDF »

Recombinant Sickle Hemoglobin Containing a Lysine Substitution at Asp-85(alpha ): Expression in Yeast, Functional Properties, and Participation in Gel Formation.

J.-P. Himanen, A. M. Popowicz, and J. M. Manning (1997)
Blood 89, 4196-4203
 |  Abstract »  |  Full Text »  |  PDF »

A Recombinant Sickle Hemoglobin Triple Mutant with Independent Inhibitory Effects on Polymerization.

J.-P. Himanen, U. A. Mirza, B. T. Chait, R. M. Bookchin, and J. M. Manning (1996)
J. Biol. Chem. 271, 25152-25156
 |  Abstract »  |  Full Text »  |  PDF »

Participation and Strength of Interaction of Lysine 95([IMAGE]) in the Polymerization of Hemoglobin S as Determined by Its Site-directed Substitution by Isoleucine.

J.-P. Himanen, K. Schneider, B. Chait, and J. M. Manning (1995)
J. Biol. Chem. 270, 13885-13891
 |  Abstract »  |  Full Text »  |  PDF »

The biophysics of sickle cell hydroxyurea therapy.

W. Eaton and J Hofrichter (1995)
Science 268, 1142-1143
 |  PDF »

Molecular Medicine: A Spin-off From the Helix.

C. T. Caskey (1993)
JAMA 269, 1986-1992
 |  Abstract »  |  PDF »

A Short-Term Trial of Butyrate to Stimulate Fetal-Globin-Gene Expression in the {beta}-Globin Disorders.

S. P. Perrine, G. D. Ginder, D. V. Faller, G. H. Dover, T. Ikuta, H. E. Witkowska, S.-p. Cai, E. P. Vichinsky, and N. F. Olivieri (1993)
N. Engl. J. Med. 328, 81-86
 |  Abstract »  |  Full Text »

A receptor-mediated pathway for cholesterol homeostasis.

M. Brown and J. Goldstein (1986)
Science 232, 34-47
 |  PDF »

Sickle Cell Anemia.

C. S. Johnson (1985)
JAMA 254, 1958-1963
 |  Abstract »  |  PDF »

Life-Threatening Complications of Sickle Cell Disease in Children.

M. L. Mills (1985)
JAMA 254, 1487-1491
 |  Abstract »  |  PDF »

Separation Techniques Based on the Opposition of Two Counteracting Forces to Produce a Dynamic Equilibrium.

P. H. O'FARRELL (1985)
Science 227, 1586-1589
 |  Abstract »  |  PDF »

Rational approaches to chemotherapy: antisickling agents.

I. Klotz, D. Haney, and L. King (1981)
Science 213, 724-731
 |  PDF »

Aggregation effects on oxygen binding of sickle cell hemoglobin.

S. Gill, R Skold, L Fall, T Shaeffer, P Spokane, and J Wyman (1978)
Science 201, 362-364
 |  Abstract »  |  PDF »

Sickle hemoglobin aggregation: a new class of inhibitors.

Votano JR, M Gorecki, and A Rich (1977)
Science 196, 1216-1219
 |  Abstract »  |  PDF »

Highlights of Two Centuries of American Pediatrics, 1776-1976.

T. E. Cone Jr (1976)
Arch Pediatr Adolesc Med 130, 762-775
 |  Abstract »  |  PDF »

Optimal vs Optional Testing For Sickle Cell Disease.

E. L. Bemis (1975)
JAMA 234, 855-856
 |  Abstract »  |  PDF »

Sickle Cell Anemia 1910-1973: An Overview.

L. S. Lessin and W. N. Jensen (1974)
Arch Intern Med 133, 529-532
 |  Abstract »  |  PDF »

Hemoglobin Interaction and Molecular Basis of Sickling.

J. F. Bertles (1974)
Arch Intern Med 133, 538-543
 |  Abstract »  |  PDF »

Ultrastructural Features of Erythrocyte and Hemoglobin Sickling.

J. G. White (1974)
Arch Intern Med 133, 545-562
 |  Abstract »  |  PDF »

The Genetics of Sickle Cell Anemia and Related Syndromes.

D. L. Rucknagel (1974)
Arch Intern Med 133, 595-606
 |  Abstract »  |  PDF »

Hemolysis in Sickle Cell Disease.

T. A. Bensinger and P. N. Gillette (1974)
Arch Intern Med 133, 624-631
 |  Abstract »  |  PDF »

New Prospects for Understanding and Control of Genetic Diseases.

J. E. Seegmiller (1972)
Arch Intern Med 130, 181-185
 |  Abstract »  |  PDF »

Health Care Priority and Sickle Cell Anemia.

R. B. Scott (1970)
JAMA 214, 731-734
 |  Abstract »  |  PDF »

Hemoglobin Interaction: Modification of Solid Phase Composition in the Sickling Phenomenon.

J. F. Bertles, R. Rabinowitz, and J. Dobler (1970)
Science 169, 375-377
 |  Abstract »  |  PDF »

Origins of Molecular Biology.

E. L. Hess (1970)
Science 168, 664-669
 |  PDF »

Oxidative and Photosynthetic Phosphorylation Mechanisms.

J. H. Wang (1970)
Science 167, 25-30
 |  PDF »

Hemoglobin M--An Early Chapter in the Saga of Molecular Pathology.

P. HELLER (1969)
Ann Intern Med 70, 1038-1041
 |  Abstract »  |  PDF »

Orthomolecular Psychiatry: Varying the concentrations of substances normally present in the human body may control mental disease.

L. Pauling (1968)
Science 160, 265-271
 |  Abstract »  |  PDF »

Clinical Features of Hemoglobin CHarlem, A New Sickling Hemoglobin Variant.

R. M. BOOKCHIN, R. P. DAVIS, and H. M. RANNEY (1968)
Ann Intern Med 68, 8-18
 |  Abstract »  |  PDF »

Tonsillectomy and Hemoglobin C-C Disease: A Case Report.

A. M. FULLER, R. HUNT, and P. A. BARELLI (1967)
Arch Otolaryngol Head Neck Surg 85, 99-101
 |  Abstract »  |  PDF »

Hemoglobin Freiburg: Abnormal Hemoglobin Due to Deletion of a Single Amino Acid Residue.

R. T. Jones, B. Brimhall, T. H. J. Huisman, E. Kleihauer, and K. Betke (1966)
Science 154, 1024-1027
 |  Abstract »  |  PDF »

Sickle-Cell Hemoglobin and Its Relation to Fundus Abnormality.

R. B. WELCH and M. F. GOLDBERG (1966)
Arch Ophthalmol 75, 353-362
 |  Abstract »  |  PDF »

Biochemical Genetics and Man: Accomplishments and Problems.

H. E. Sutton (1965)
Science 150, 858-862
 |  PDF »

Fatal Hemoglobin S-C Disease Crises Following Tonsillectomy.

J. M. ROSENBAUM (1965)
Arch Otolaryngol Head Neck Surg 82, 307-309
 |  Abstract »  |  PDF »

Genetic Aspects of Neurological Disease.

H. ZELLWEGER (1965)
Arch Intern Med 115, 387-397
 |  Abstract »  |  PDF »

Hemoglobin Polymorphism: Its Relation to Sickling of Erythrocytes in White-Tailed Deer.

H. Kitchen, F. W. Putnam, and W. J. Taylor (1964)
Science 144, 1237-1239
 |  Abstract »  |  PDF »

Compensatory Effects in the Synthesis of Hemoglobin Polypeptide Chains.

E. Zuckerkandl (1964)
Cold Spring Harb Symp Quant Biol 29, 357-374
 |  Abstract »  |  PDF »

Pseudoxanthoma Elasticum and Sickle Cell Anemia.

K. C. SUERIG and F. E. SIEFERT (1964)
Arch Intern Med 113, 135-141
 |  Abstract »  |  PDF »

JAMES B. HERRICK (1861-1954).

(1963)
JAMA 186, 722-723
 |  Abstract »  |  PDF »

Cholelithiasis in a Child with Sickle Cell Anemia: Case Report and Review.

E. A. DAINKO, A. F. BOWYER, F. R. JOHNSON, and E. J. BEATTIE (1963)
Arch Surg 86, 203-208
 |  Abstract »  |  PDF »

Congenital Nonspherocytic Hemolytic Anemia: Studies on a Family with a Qualitative Defect in Glucose-6-Phosphate Dehydrogenase.

H. N. KIRKMAN and H. D. RILEY JR. (1961)
Arch Pediatr Adolesc Med 102, 313-320
 |  Abstract »  |  PDF »

Sickle-Cell Anemia: Comment on Diagnosis and a Report on Splenectomy in Two Sisters.

G. HILKOVITZ and W. W. MARTIN JR. (1961)
Arch Intern Med 108, 109-113
 |  Abstract »  |  PDF »

Effect of Carbonic Anhydrase Inhibitors on the Course of Sickle-Cell Disease.

A. B. HENDERSON, E. J. CROCKETT, and C. H. WRIGHT (1959)
Arch Intern Med 104, 68-71
 |  Abstract »  |  PDF »

Multiple Hemoglobins in Fishes.

D. R. BUHLER and W. E. SHANKS (1959)
Science 129, 899-900
 |  Abstract »  |  PDF »

SICKLE CELL-HEMOGLOBIN D DISEASE.

E. W. SMITH and C. L. CONLEY (1959)
Ann Intern Med 50, 94-105
 |  Abstract »  |  PDF »

Milestones in Scientific Pediatrics.

A. A. WEECH (1958)
Arch Pediatr Adolesc Med 96, 553-558
 |  Abstract »  |  PDF »

HEMOLYTIC DISORDERS: SOME HIGHLIGHTS OF TWENTY YEARS OF PROGRESS.

L. E. YOUNG (1958)
Ann Intern Med 49, 1073-1089
 |  Abstract »  |  PDF »

INCIDENCE OF THYROTOXICOSIS AMONG REFUGEES FROM NAZI PRISON CAMPS.

S. A. WEISMAN (1958)
Ann Intern Med 48, 747-752
 |  Abstract »  |  PDF »

SURGICAL MANAGEMENT OF SICKLE CELL ANEMIA: THE USE OF PACKED RED BLOOD CELL TRANSFUSIONS.

J. A. NADEL and A. P. SPIVACK (1958)
Ann Intern Med 48, 399-406
 |  Abstract »  |  PDF »

Ocular Manifestations of Sickle-Cell Disease.

G. GOODMAN, L. von SALLMANN, and M. G. HOLLAND (1957)
Arch Ophthalmol 58, 655-682
 |  Abstract »  |  PDF »

Leg Ulcers Associated with Mediterranean Anemia (Thalassemia Major and Minor).

A. S. ZELICKSON (1957)
Arch Dermatol 76, 351-356
 |  Abstract »  |  PDF »

MOLECULAR DISEASES OF HEMOGLOBIN. I. INTRODUCTION AND INCIDENCE.

T. P. HAYNIE, H. L. DOBSON, and R. A. HETTIG (1957)
Ann Intern Med 46, 1031-1038
 |  Abstract »  |  PDF »

Clinical Diagnosis of Sickle-C Disease.

W. F. DENNY, T. O. FINN, and R. M. BIRD (1957)
Arch Intern Med 99, 214-217
 |  Abstract »  |  PDF »

mechanisms of Destruction of Red Cells in Certain Hemolytic Conditions.

T. H. HAM, R. WEISMAN Jr., and C. F. HINZ Jr. (1956)
Arch Intern Med 98, 574-592
 |  Abstract »  |  PDF »

Studies on the Destruction of Red Blood Cells: X. The Biophysics and Biology of Sickle-Cell Disease.

J. W. HARRIS, H. H. BREWSTER, T. H. HAM, and W. B. CASTLE (1956)
Arch Intern Med 97, 145-168
 |  Abstract »  |  PDF »

SICKLE-CELL-HEMOGLOBIN-C DISEASE: Report of a Case with Electrophoretic Studies of Hemoglobin in Family Members.

N. B. SCHELL and J. M. McGINLEY (1956)
Arch Pediatr Adolesc Med 91, 38-44
 |  Abstract »  |  PDF »

Studies in Sickle-Cell Anemia: VIII. Further Observations on the Clinical Manifestations of Sickle-Cell Anemia in Children.

R. B. SCOTT, A. D. FERGUSON, M. E. JENKINS, and H. M. CLARK (1955)
Arch Pediatr Adolesc Med 90, 682-691
 |  Abstract »  |  PDF »

The Hematuria of Abnormal Hemoglobin Diseases.

S. M. GOLDMAN, A. Z. CHAPMAN, and R. R. CROSS Jr. (1955)
Arch Surg 71, 881-884
 |  Abstract »  |  PDF »

Clinical States Associated with Alterat of the Hemoglobin Molecule: The Minot Lecture.

H. A. ITANO (1955)
Arch Intern Med 96, 287-297
 |  Abstract »  |  PDF »

New Hemoglobin in Normal Adult Blood.

H. G. KUNKEL and G. WALLENIUS (1955)
Science 122, 288
 |  PDF »

SICKLE CELL-HEMOGLOBIN C DISEASE.

E. F. HAYS and R. L. ENGLE JR. (1955)
Ann Intern Med 43, 412-418
 |  Abstract »  |  PDF »

Sickle Cell Trait and Disease in Pulmonary Tuberculosis.

R. ROSENBLUM, B. KABAKOW, H. C. LICHTMAN, and H. A. LYONS (1955)
Arch Intern Med 95, 540-542
 |  Abstract »  |  PDF »

New Hemoglobin Possessing a Higher Electrophoretic Mobility than Normal Adult Hemoglobin.

D. A. RIGAS, R. D. KOLER, and E. E. OSGOOD (1955)
Science 121, 372
 |  PDF »

ASPECTS OF POLYMORPHISM IN MAN.

A. C. Allison (1955)
Cold Spring Harb Symp Quant Biol 20, 239-255
 |  Abstract »  |  PDF »

TREATMENT OF SICKLE CELL ANEMIA.

B. S. LEAVELL (1954)
Arch Intern Med 94, 801-805
 |  Abstract »  |  PDF »

To Advertise   |   Find Products