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TheGlobalCirculationofSeasonal Influenza A (H3N2) Viruses
Colin A. Russell,1Terry C. Jones,1,2,3Ian G. Barr,4Nancy J. Cox,5Rebecca J. Garten,5Vicky Gregory,6Ian D. Gust,4Alan W. Hampson,4Alan J. Hay,6Aeron C. Hurt,4Jan C. de Jong,2Anne Kelso,4Alexander I. Klimov,5Tsutomu Kageyama,7Naomi Komadina,4Alan S. Lapedes,8Yi P. Lin,6Ana Mosterin,1,3Masatsugu Obuchi,7Takato Odagiri,7Albert D. M. E. Osterhaus,2Guus F. Rimmelzwaan,2Michael W. Shaw,5Eugene Skepner,1Klaus Stohr,9Masato Tashiro,7Ron A. M. Fouchier,2Derek J. Smith1,2*
Antigenic and genetic analysis ofthe hemagglutinin of13,000human influenza A (H3N2) viruses from six continents during2002–2007 revealed that there was continuous circulationin east and Southeast Asia (E-SE Asia) via a region-wide networkof temporally overlapping epidemics and that epidemics in thetemperate regions were seeded from this network each year. Seedstrains generally first reached Oceania, North America, andEurope, and later South America. This evidence suggests thatonce A (H3N2) viruses leave E-SE Asia, they are unlikely tocontribute to long-term viral evolution. If the trends observedduring this period are an accurate representation of overallpatterns of spread, then the antigenic characteristics of A(H3N2) viruses outside E-SE Asia may be forecast each year basedon surveillance within E-SE Asia, with consequent improvementsto vaccine strain selection.
1 Department of Zoology, University of Cambridge, Cambridge, UK. 2 Department of Virology, Erasmus Medical Centre, Rotterdam, Netherlands. 3 Universitat Pompeu Fabra, Barcelona, Spain. 4 World Health Organization (WHO) Collaborating Centre for Reference and Research on Influenza, Melbourne, Australia. 5 WHO Collaborating Center for Influenza, Centers for Disease Control and Prevention, Atlanta, GA, USA. 6 WHO Collaborating Centre for Influenza, National Institute for Medical Research (NIMR), London, UK. 7 WHO Collaborating Center for Influenza, National Institute for Infectious Diseases, Tokyo, Japan. 8Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, USA. 9 Novartis Vaccines and Diagnostics, Cambridge, MA, USA.
* To whom correspondence should be addressed. E-mail: dsmith{at}zoo.cam.ac.uk
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S.-W. Huang, Y.-W. Hsu, D. J. Smith, D. Kiang, H.-P. Tsai, K.-H. Lin, S.-M. Wang, C.-C. Liu, I.-J. Su, and J.-R. Wang (2009)
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47, 3653-3662
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Mixed Infection and the Genesis of Influenza Virus Diversity.
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J. Virol.
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301, 1066-1069
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Influenza seasonality: Lifting the fog.
M. Lipsitch and C. Viboud (2009)
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106, 3645-3646
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Y. Suzuki, K. Taira, R. Saito, M. Nidaira, S. Okano, H. Zaraket, and H. Suzuki (2009)
J. Clin. Microbiol.
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Influenza sequence and epitope database.
S. Yang, J.-Y. Lee, J. S. Lee, W. P. Mitchell, H.-B. Oh, C. Kang, and K. H. Kim (2009)
Nucleic Acids Res.
37, D423-D430
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Churchill's flu poem.
A. Nicoll, K. Mori, and M. Tashiro (2008)
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Studies Reveal How Influenza Virus Antigenic Variation Develops and Spreads.
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13,000 human influenza A (H3N2) viruses from six continents during 2002–2007 revealed that there was continuous circulation in east and Southeast Asia (E-SE Asia) via a region-wide network of temporally overlapping epidemics and that epidemics in the temperate regions were seeded from this network each year. Seed strains generally first reached Oceania, North America, and Europe, and later South America. This evidence suggests that once A (H3N2) viruses leave E-SE Asia, they are unlikely to contribute to long-term viral evolution. If the trends observed during this period are an accurate representation of overall patterns of spread, then the antigenic characteristics of A (H3N2) viruses outside E-SE Asia may be forecast each year based on surveillance within E-SE Asia, with consequent improvements to vaccine strain selection. 
