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Science 8 August 2008:
Vol. 321. no. 5890, pp. 824 - 826
DOI: 10.1126/science.1157312
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Reports

Programming DNA Tube Circumferences

Peng Yin,1,2,3{dagger} Rizal F. Hariadi,4 Sudheer Sahu,6 Harry M. T. Choi,2 Sung Ha Park,1,5* Thomas H. LaBean,6,7 John H. Reif6

Synthesizing molecular tubes with monodisperse, programmable circumferences is an important goal shared by nanotechnology, materials science, and supermolecular chemistry. We program molecular tube circumferences by specifying the complementarity relationships between modular domains in a 42-base single-stranded DNA motif. Single-step annealing results in the self-assembly of long tubes displaying monodisperse circumferences of 4, 5, 6, 7, 8, 10, or 20 DNA helices.

1 Department of Computer Science, California Institute of Technology, Pasadena, CA 91125, USA.
2 Department of Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA.
3 Center for Biological Circuit Design, California Institute of Technology, Pasadena, CA 91125, USA.
4 Department of Applied Physics, California Institute of Technology, Pasadena, CA 91125, USA.
5 Center for the Physics of Information, California Institute of Technology, Pasadena, CA 91125, USA.
6 Department of Computer Science, Duke University, Durham, NC 27708, USA.
7 Department of Chemistry, Duke University, Durham, NC 27708, USA.

* Present address: Department of Physics, SKKU Advanced Institute of Nanotechnology, Sungkyunkwan University, Suwon, 440-746, Korea.

{dagger} To whom correspondence should be addressed. E-mail: py{at}caltech.edu

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