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Science 1 August 2008:
Vol. 321. no. 5889, p. 640
DOI: 10.1126/science.1153997
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Technical Comments

Comment on "Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain"

Jacobus F. A. Jansen,1,2* John D. Gearhart,3,5 Jeff W. M. Bulte4,5

Manganas et al. (Reports, 9 November 2007, p. 980) reported the discovery of a biomarker specific for neural progenitor cells detectable using magnetic resonance spectroscopy. A new algorithm was developed to extract the biomarker from noisy in vivo data. We question how this algorithm was validated, because the biomarker overlaps with peaks from nonspecific lipid signals.

1 Departments of Medical Physics and Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
2 Department of Radiology, Maastricht University Hospital, Post Office Box 5800, 6202 AZ Maastricht, Netherlands.
3 Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Broadway Research Building, Room 779, 733 North Broadway, Baltimore, MD 21205, USA.
4 Departments of Radiology and Chemical and Biomolecular Engineering, Johns Hopkins University School of Medicine, 217 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA.
5 Cellular Imaging Section, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Broadway Research Building, Suite 643, 733 North Broadway, Baltimore, MD 21205, USA.

* To whom correspondence should be addressed. E-mail: jansenjfa{at}gmail.com

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Science. ISSN 0036-8075 (print), 1095-9203 (online)