Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
GoGreen Membership

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 23 May 2008:
Vol. 320. no. 5879, p. 1012
DOI: 10.1126/science.1152620
Prev | Table of Contents | Next

Technical Comments

Response to Comment on "Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis"

Akiko Taguchi and Morris F. White*

Differences in reported life span of mice heterozygous for a null allele of the insulin receptor substrate–2 (Irs2) might involve the effects of diet, breeding strategies, and genetic background on insulin-like signaling cascades. A better understanding will emerge from studies focusing on the coordination of nutrient homeostasis and life span by insulin-like signaling in specific peripheral tissues and the central nervous system.

Howard Hughes Medical Institute, Division of Endocrinology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

* To whom correspondence should be addressed. E-mail: morris.white{at}childrens.harvard.edu

Read the Full Text

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)