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Rapid Erasure of Long-Term Memory Associations in the Cortex by an Inhibitor of PKM
Reut Shema,1Todd Charlton Sacktor,2Yadin Dudai1*
Little is known about the neuronal mechanisms that subservelong-term memory persistence in the brain. The components ofthe remodeled synaptic machinery, and how they sustain the newsynaptic or cellwide configuration over time, are yet to beelucidated. In the rat cortex, long-term associative memoriesvanished rapidly after local application of an inhibitor ofthe protein kinase C isoform, protein kinase M zeta (PKM). Theeffect was observed for at least several weeks after encodingand may be irreversible. In the neocortex, which is assumedto be the repository of multiple types of long-term memory,persistence of memory is thus dependent on ongoing activityof a protein kinase long after that memory is considered tohave consolidated into a long-term stable form.
1 Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel. 2 Departments of Physiology, Pharmacology, and Neurology, The Robert F. Furchgott Center for Neural and Behavioral Science, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.
* To whom correspondence should be addressed. E-mail: yadin.dudai{at}weizmann.ac.il
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). The effect was observed for at least several weeks after encoding and may be irreversible. In the neocortex, which is assumed to be the repository of multiple types of long-term memory, persistence of memory is thus dependent on ongoing activity of a protein kinase long after that memory is considered to have consolidated into a long-term stable form. 
