Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 9 February 2007:
Vol. 315. no. 5813, p. 766
DOI: 10.1126/science.1137136
Prev | Table of Contents | Next

Technical Comments

Response to Comment on "Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake"

Jian V. Zhang,1 Cynthia Klein,1 Pei-Gen Ren,1 Stefan Kass,2 Luc Ver Donck,2 Dieder Moechars,2 Aaron J. W. Hsueh1*

We cannot reproduce our original findings on obestatin binding and activation of GPR39 receptors in vitro. However, we can reproduce our original findings on the in vivo effects of obestatin in mice (decreases in food intake, gastric emptying responses, and body weight gain) under precise experimental conditions. Further studies are needed to reveal the exact relation between obestatin and the G protein–coupled receptor GPR39.

1 Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305, USA.
2 Johnson and Johnson Pharmaceutical Research and Development, a Division of Janssen Pharmaceutica NV, Beerse, Belgium.

* To whom correspondence should be addressed. E-mail: aaron.hsueh{at}stanford.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Two alternatively spliced GPR39 transcripts in seabream: molecular cloning, genomic organization, and regulation of gene expression by metabolic signals.
Y. Zhang, Y. Liu, X. Huang, X. Liu, B. Jiao, Z. Meng, P. Zhu, S. Li, H. Lin, and C. H K Cheng (2008)
J. Endocrinol. 199, 457-470
   Abstract »    Full Text »    PDF »
Obestatin inhibits motor activity in the antrum and duodenum in the fed state of conscious rats.
K. Ataka, A. Inui, A. Asakawa, I. Kato, and M. Fujimiya (2008)
Am J Physiol Gastrointest Liver Physiol 294, G1210-G1218
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)