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Science 24 November 2006:
Vol. 314. no. 5803, p. 1243
DOI: 10.1126/science.1129811
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Technical Comments

Comment on Papers by Chong et al., Nishio et al., and Suri et al. on Diabetes Reversal in NOD Mice

Denise L. Faustman,1* Simon D. Tran,2 Shohta Kodama,3 Beatrijs M. Lodde,4 Ildiko Szalayova,4 Sharon Key,4 Zsuzsanna E. Toth,4 Éva Mezey4*

Chong et al., Nishio et al., and Suri et al. (Reports, 24 March 2006, pp. 1774, 1775, and 1778) confirmed that treating nonobese diabetic (NOD) mice with an immune adjuvant and semisyngenic spleen cells can reverse the disease but found that spleen cells did not contribute to the observed recovery of pancreatic islets. We show that islet regeneration predominately originates from endogenous cells but that introduced spleen cells can also contribute to islet recovery.

1 Massachusetts General Hospital, Charlestown, MA 02129, USA.
2 McGill University, Montreal, Quebec, Canada.
3 Brigham and Women's Hospital, Boston, MA 02215, USA.
4 National Institutes of Health, Bethesda, MD 20892, USA.

* To whom correspondence should be addressed. E-mail: faustman{at}helix.mgh.harvard.edu (D.L.F.); mezeye{at}mail.nih.gov (E.M.)

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Science. ISSN 0036-8075 (print), 1095-9203 (online)