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Science 8 September 2006:
Vol. 313. no. 5792, p. 1389
DOI: 10.1126/science.1128745
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Technical Comments

Response to Comment on "Transitions to Asexuality Result in Excess Amino Acid Substitutions"

Susanne Paland1* and Michael Lynch2

Asexual populations experience a reduction in the efficiency of selection when compared with sexual populations. Because asexual lineages of Daphnia pulex exhibit no consistent change in mitochondrial base-composition bias, Butlin suggests that this bias is not maintained by selection. On the basis of frequencies of polymorphic directional base changes, we suggest that it predominantly reflects mutation bias.

1 Center for Genomics and Bioinformatics, Indiana University, 1001 East 3rd Street, Bloomington, IN 47405, USA.
2 Department of Biology, Indiana University, 1001 East 3rd Street, Bloomington, IN 47405, USA.

* To whom correspondence should be addressed. E-mail: spaland{at}indiana.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)