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Science 14 July 2006:
Vol. 313. no. 5784, p. 172
DOI: 10.1126/science.1122822
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Technical Comments

Response to Comment on "Ongoing Adaptive Evolution of ASPM, a Brain Size Determinant in Homo sapiens" and "Microcephalin, a Gene Regulating Brain Size, Continues to Evolve Adaptively in Humans"

Nitzan Mekel-Bobrov,1,2 Patrick D. Evans,1,2 Sandra L. Gilbert,1 Eric J. Vallender,1,2 Richard R. Hudson,3 Bruce T. Lahn1*

Currat et al. present computer simulations to argue that the haplotype structure found at the microcephalin and ASPM genes can be better explained by demographic history rather than by selection. The demographic models they adopt, however, strongly contradict a decade of empirical research on human demographic history and do not account for the critical features of the data on which our argument for selection was based.

1 Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
2 Committee on Genetics, University of Chicago, Chicago, IL 60637, USA.
3 Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA.

* To whom correspondence should be addressed. E-mail: blahn{at}bsd.uchicago.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
From the Cover: Linguistic tone is related to the population frequency of the adaptive haplogroups of two brain size genes, ASPM and Microcephalin.
D. Dediu and D. R. Ladd (2007)
PNAS 104, 10944-10949
   Abstract »    Full Text »    PDF »
Stepping-Stone Spatial Structure Causes Slow Decay of Linkage Disequilibrium and Shifts the Site Frequency Spectrum.
A. De and R. Durrett (2007)
Genetics 176, 969-981
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)