Response to Comment on "Evidence for Positive Epistasis in HIV-1"

doi:10.1126/science.1110994

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Response to Comment on "Evidence for Positive Epistasis in HIV-1"

Sebastian Bonhoeffer,¹^* Colombe Chappey,² Neil T. Parkin,² Jeannette M. Whitcomb,² Christos J. Petropoulos²

Wang et al. analyzed artificially biased data to show that ourresults can be explained by a bias against sequences with lowfitness. We explicitly acknowledged this potential caveat inour original study. Showing that an artificially introducedbias can produce a spurious signal of positive epistasis doesnot demonstrate that such bias exists in our original data.

¹ Institute of Integrative Biology, ETH Zurich, ETH Zentrum CHN, CH-8092 Zurich, Switzerland.
² Monogram BioSciences, Inc., 345 Oyster Point Boulevard, South San Francisco, CA 94080–1913, USA.

^* To whom correspondence should be addressed. E-mail: sebastian.bonhoeffer{at}env.ethz.ch

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In Science Magazine

TECHNICAL COMMENTS Comment on "Evidence for Positive Epistasis in HIV-1": Kai Wang, John E. Mittler, and Ram Samudrala (12 May 2006)
Science 312 (5775), 848b. [DOI: 10.1126/science.1109904]
| Abstract » | Full Text » | PDF »

REPORTS Evidence for Positive Epistasis in HIV-1: Sebastian Bonhoeffer, Colombe Chappey, Neil T. Parkin, Jeanette M. Whitcomb, and Christos J. Petropoulos (26 November 2004)
Science 306 (5701), 1547. [DOI: 10.1126/science.1101786]
| Abstract » | Full Text » | PDF » | Supporting Online Material »