Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 2 September 2005:
Vol. 309. no. 5740, pp. 1514 - 1518
DOI: 10.1126/science.1111443
Prev | Table of Contents | Next

Review

From Birth to Death: The Complex Lives of Eukaryotic mRNAs

Melissa J. Moore

Recent work indicates that the posttranscriptional control of eukaryotic gene expression is much more elaborate and extensive than previously thought, with essentially every step of messenger RNA (mRNA) metabolism being subject to regulation in an mRNA-specific manner. Thus, a comprehensive understanding of eukaryotic gene expression requires an appreciation for how the lives of mRNAs are influenced by a wide array of diverse regulatory mechanisms.

Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, 415 South Street, Waltham, MA 02454. E-mail: mmoore{at}brandeis.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
MKP-1 mRNA Stabilization and Translational Control by RNA-Binding Proteins HuR and NF90.
Y. Kuwano, H. H. Kim, K. Abdelmohsen, R. Pullmann Jr., J. L. Martindale, X. Yang, and M. Gorospe (2008)
Mol. Cell. Biol. 28, 4562-4575
   Abstract »    Full Text »    PDF »
Nuclear HuR accumulation through phosphorylation by Cdk1.
H. H. Kim, K. Abdelmohsen, A. Lal, R. Pullmann Jr., X. Yang, S. Galban, S. Srikantan, J. L. Martindale, J. Blethrow, K. M. Shokat, et al. (2008)
Genes & Dev. 22, 1804-1815
   Abstract »    Full Text »    PDF »
Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites.
R. Sandberg, J. R. Neilson, A. Sarma, P. A. Sharp, and C. B. Burge (2008)
Science 320, 1643-1647
   Abstract »    Full Text »    PDF »
Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP.
H. Kawahara, T. Imai, H. Imataka, M. Tsujimoto, K. Matsumoto, and H. Okano (2008)
J. Cell Biol. 181, 639-653
   Abstract »    Full Text »    PDF »
The Gene for the P-Subunit of Glycine Decarboxylase from the C4 Species Flaveria trinervia: Analysis of Transcriptional Control in Transgenic Flaveria bidentis (C4) and Arabidopsis (C3).
S. Engelmann, C. Wiludda, J. Burscheidt, U. Gowik, U. Schlue, M. Koczor, M. Streubel, R. Cossu, H. Bauwe, and P. Westhoff (2008)
Plant Physiology 146, 1773-1785
   Abstract »    Full Text »    PDF »
Post-transcriptional Regulation of Neuro-oncological Ventral Antigen 1 by the Neuronal RNA-binding Proteins ELAV.
A. Ratti, C. Fallini, C. Colombrita, A. Pascale, U. Laforenza, A. Quattrone, and V. Silani (2008)
J. Biol. Chem. 283, 7531-7541
   Abstract »    Full Text »    PDF »
Cell Type-specific Post-transcriptional Regulation of Production of the Potent Antiangiogenic and Proatherogenic Protein Thrombospondin-1 by High Glucose.
S. Bhattacharyya, T. E. Marinic, I. Krukovets, G. Hoppe, and O. I. Stenina (2008)
J. Biol. Chem. 283, 5699-5707
   Abstract »    Full Text »    PDF »
Regulation of Alternative Splicing by Reversible Protein Phosphorylation.
S. Stamm (2008)
J. Biol. Chem. 283, 1223-1227
   Abstract »    Full Text »    PDF »
PTB/hnRNP I Is Required for RNP Remodeling during RNA Localization in Xenopus Oocytes.
R. A. Lewis, J. A. Gagnon, and K. L. Mowry (2008)
Mol. Cell. Biol. 28, 678-686
   Abstract »    Full Text »    PDF »
Assembly of the Yin Yang 1 Transcription Factor into Messenger Ribonucleoprotein Particles Requires Direct RNA Binding Activity.
Z. R. Belak and N. Ovsenek (2007)
J. Biol. Chem. 282, 37913-37920
   Abstract »    Full Text »    PDF »
Proteolytic Gene Expression Differs At Rest and After Resistance Exercise Between Young and Old Women.
U. Raue, D. Slivka, B. Jemiolo, C. Hollon, and S. Trappe (2007)
J. Gerontol. A Biol. Sci. Med. Sci. 62, 1407-1412
   Abstract »    Full Text »    PDF »
The p38 MAPK Pathway Mediates Aryl Propionic Acid Induced Messenger RNA Stability of p75NTR in Prostate Cancer Cells.
E. J. Quann, F. Khwaja, and D. Djakiew (2007)
Cancer Res. 67, 11402-11410
   Abstract »    Full Text »    PDF »
Reply to Dr. Heinemeier.
M. M. Bamman (2007)
J Appl Physiol 103, 1915
   Full Text »    PDF »
Time course of proteolytic, cytokine, and myostatin gene expression after acute exercise in human skeletal muscle.
E. Louis, U. Raue, Y. Yang, B. Jemiolo, and S. Trappe (2007)
J Appl Physiol 103, 1744-1751
   Abstract »    Full Text »    PDF »
Effects of rehabilitative exercise on peripheral muscle TNF{alpha}, IL-6, IGF-I and MyoD expression in patients with COPD.
I. Vogiatzis, G. Stratakos, D. C M Simoes, G. Terzis, O. Georgiadou, C. Roussos, and S. Zakynthinos (2007)
Thorax 62, 950-956
   Abstract »    Full Text »    PDF »
Splicing- and cleavage-independent requirement of RNA polymerase II CTD for mRNA release from the transcription site.
N. Custodio, M. Vivo, M. Antoniou, and M. Carmo-Fonseca (2007)
J. Cell Biol. 179, 199-207
   Abstract »    Full Text »    PDF »
Kaposi's Sarcoma-Associated Herpesvirus ORF57 Protein Enhances mRNA Accumulation Independently of Effects on Nuclear RNA Export.
M. Nekorchuk, Z. Han, T.-T. Hsieh, and S. Swaminathan (2007)
J. Virol. 81, 9990-9998
   Abstract »    Full Text »    PDF »
Analysis of Turnover and Translation Regulatory RNA-Binding Protein Expression through Binding to Cognate mRNAs.
R. Pullmann Jr., H. H. Kim, K. Abdelmohsen, A. Lal, J. L. Martindale, X. Yang, and M. Gorospe (2007)
Mol. Cell. Biol. 27, 6265-6278
   Abstract »    Full Text »    PDF »
An Interaction between Two RNA Binding Proteins, Nab2 and Pub1, Links mRNA Processing/Export and mRNA Stability.
L. H. Apponi, S. M. Kelly, M. T. Harreman, A. N. Lehner, A. H. Corbett, and S. R. Valentini (2007)
Mol. Cell. Biol. 27, 6569-6579
   Abstract »    Full Text »    PDF »
FRET-detectable interactions between the ARE binding proteins, HuR and p37AUF1.
P. S. David, R. Tanveer, and J. D. Port (2007)
RNA 13, 1453-1468
   Abstract »    Full Text »    PDF »
Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs.
Y. Yuan, S. A. Compton, K. Sobczak, M. G. Stenberg, C. A. Thornton, J. D. Griffith, and M. S. Swanson (2007)
Nucleic Acids Res.
   Abstract »    Full Text »    PDF »
Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function.
O. Isken and L. E. Maquat (2007)
Genes & Dev. 21, 1833-3856
   Abstract »    Full Text »    PDF »
Recognition of polyadenosine RNA by zinc finger proteins.
S. M. Kelly, S. A. Pabit, C. M. Kitchen, P. Guo, K. A. Marfatia, T. J. Murphy, A. H. Corbett, and K. M. Berland (2007)
PNAS 104, 12306-12311
   Abstract »    Full Text »    PDF »
RNABindR: a server for analyzing and predicting RNA-binding sites in proteins.
M. Terribilini, J. D. Sander, J.-H. Lee, P. Zaback, R. L. Jernigan, V. Honavar, and D. Dobbs (2007)
Nucleic Acids Res. 35, W578-W584
   Abstract »    Full Text »    PDF »
The 3' Untranslated Region Complex Involved in Stabilization of Human {alpha}-globin mRNA Assembles in the Nucleus and Serves an Independent Role as a Splice Enhancer.
X. Ji, J. Kong, R. P. Carstens, and S. A. Liebhaber (2007)
Mol. Cell. Biol. 27, 3290-3302
   Abstract »    Full Text »    PDF »
Molecular Composition of IMP1 Ribonucleoprotein Granules.
L. Jonson, J. Vikesaa, A. Krogh, L. K. Nielsen, T. vO. Hansen, R. Borup, A. H. Johnsen, J. Christiansen, and F. C. Nielsen (2007)
Mol. Cell. Proteomics 6, 798-811
   Abstract »    Full Text »    PDF »
Interaction of yeast RNA-binding proteins Nrd1 and Nab3 with RNA polymerase II terminator elements.
K. L. Carroll, R. Ghirlando, J. M. Ames, and J. L. Corden (2007)
RNA 13, 361-373
   Abstract »    Full Text »    PDF »
Antiviral Protein APOBEC3G Localizes to Ribonucleoprotein Complexes Found in P Bodies and Stress Granules.
S. Gallois-Montbrun, B. Kramer, C. M. Swanson, H. Byers, S. Lynham, M. Ward, and M. H. Malim (2007)
J. Virol. 81, 2165-2178
   Abstract »    Full Text »    PDF »
Functional overlap between conserved and diverged KH domains in Saccharomyces cerevisiae SCP160.
M. A. Brykailo, A. H. Corbett, and J. L. Fridovich-Keil (2007)
Nucleic Acids Res. 35, 1108-1118
   Abstract »    Full Text »    PDF »
Cell stress modulates the function of splicing regulatory protein RBM4 in translation control.
J.-C. Lin, M. Hsu, and W.-Y. Tarn (2007)
PNAS 104, 2235-2240
   Abstract »    Full Text »    PDF »
LARK activates posttranscriptional expression of an essential mammalian clock protein, PERIOD1.
S. Kojima, K. Matsumoto, M. Hirose, M. Shimada, M. Nagano, Y. Shigeyoshi, S.-i. Hoshino, K. Ui-Tei, K. Saigo, C. B. Green, et al. (2007)
PNAS 104, 1859-1864
   Abstract »    Full Text »    PDF »
The PROGINS polymorphism of the human progesterone receptor diminishes the response to progesterone.
A. Romano, B. Delvoux, D.-C. Fischer, and P. Groothuis (2007)
J. Mol. Endocrinol. 38, 331-350
   Abstract »    Full Text »    PDF »
Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Regulates the Expression of PACAP in Cultured Tilapia Astrocytes.
L. Chi-Wei, S.-L. Chang, and C.-F. Weng (2007)
Experimental Biology and Medicine 232, 262-276
   Abstract »    Full Text »    PDF »
Stabilization of Cellular mRNAs and Up-Regulation of Proteins by Oligoribonucleotides Homologous to the Bcl2 Adenine-Uridine Rich Element Motif.
A. Bevilacqua, L. Ghisolfi, S. Franzi, G. Maresca, R. Gherzi, S. Capaccioli, A. Nicolin, and G. Canti (2007)
Mol. Pharmacol. 71, 531-538
   Abstract »    Full Text »    PDF »
Adenovirus Ubiquitin-Protein Ligase Stimulates Viral Late mRNA Nuclear Export.
J. L. Woo and A. J. Berk (2007)
J. Virol. 81, 575-587
   Abstract »    Full Text »    PDF »
Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment.
C. Merz, H. Urlaub, C. L. Will, and R. Luhrmann (2007)
RNA 13, 116-128
   Abstract »    Full Text »    PDF »
ApoB mRNA editing is mediated by a coordinated modulation of multiple apoB mRNA editing enzyme components.
Z. Chen, T. L. Eggerman, and A. P. Patterson (2007)
Am J Physiol Gastrointest Liver Physiol 292, G53-G65
   Abstract »    Full Text »    PDF »
RAP55, a Cytoplasmic mRNP Component, Represses Translation in Xenopus Oocytes.
K. J. Tanaka, K. Ogawa, M. Takagi, N. Imamoto, K. Matsumoto, and M. Tsujimoto (2006)
J. Biol. Chem. 281, 40096-40106
   Abstract »    Full Text »    PDF »
Identification and Stage-specific Association with the Translational Apparatus of TbZFP3, a CCCH Protein That Promotes Trypanosome Life-cycle Development.
A. Paterou, P. Walrad, P. Craddy, K. Fenn, and K. Matthews (2006)
J. Biol. Chem. 281, 39002-39013
   Abstract »    Full Text »    PDF »
Amino acid residue doublet propensity in the protein-RNA interface and its application to RNA interface prediction.
O. T. P. Kim, K. Yura, and N. Go (2006)
Nucleic Acids Res.
   Abstract »    Full Text »    PDF »
Both introns and long 3'-UTRs operate as cis-acting elements to trigger nonsense-mediated decay in plants.
S. Kertesz, Z. Kerenyi, Z. Merai, I. Bartos, T. Palfy, E. Barta, and D. Silhavy (2006)
Nucleic Acids Res. 34, 6147-6157
   Abstract »    Full Text »    PDF »
The RNA-binding protein Rrm4 is essential for polarity in Ustilago maydis and shuttles along microtubules.
P. Becht, J. Konig, and M. Feldbrugge (2006)
J. Cell Sci. 119, 4964-4973
   Abstract »    Full Text »    PDF »
The Polypyrimidine Tract-binding Protein (PTB) Is Involved in the Post-transcriptional Regulation of Human Inducible Nitric Oxide Synthase Expression.
A. Pautz, K. Linker, T. Hubrich, R. Korhonen, S. Altenhofer, and H. Kleinert (2006)
J. Biol. Chem. 281, 32294-32302
   Abstract »    Full Text »    PDF »
Post-transcriptional control of nuclear-encoded cytochrome oxidase subunits in Trypanosoma brucei: evidence for genome-wide conservation of life-cycle stage-specific regulatory elements.
M. Mayho, K. Fenn, P. Craddy, S. Crosthwaite, and K. Matthews (2006)
Nucleic Acids Res. 34, 5312-5324
   Abstract »    Full Text »    PDF »
Genome-wide analysis of mRNAs bound to the histone stem-loop binding protein.
W.H. D. Townley-Tilson, S. A. Pendergrass, W. F. Marzluff, and M. L. Whitfield (2006)
RNA 12, 1853-1867
   Abstract »    Full Text »    PDF »
Differential Stability of Thymidylate Synthase 3'-Untranslated Region Polymorphic Variants Regulated by AUF1.
R. Pullmann Jr., K. Abdelmohsen, A. Lal, J. L. Martindale, R. D. Ladner, and M. Gorospe (2006)
J. Biol. Chem. 281, 23456-23463
   Abstract »    Full Text »    PDF »
Efficacy of 3 days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. older adults.
D. J. Kosek, J.-s. Kim, J. K. Petrella, J. M. Cross, and M. M. Bamman (2006)
J Appl Physiol 101, 531-544
   Abstract »    Full Text »    PDF »
Myogenic gene expression at rest and after a bout of resistance exercise in young (18-30 yr) and old (80-89 yr) women.
U. Raue, D. Slivka, B. Jemiolo, C. Hollon, and S. Trappe (2006)
J Appl Physiol 101, 53-59
   Abstract »    Full Text »    PDF »
Thoc1/Hpr1/p84 Is Essential for Early Embryonic Development in the Mouse..
X. Wang, Y. Chang, Y. Li, X. Zhang, and D. W. Goodrich (2006)
Mol. Cell. Biol. 26, 4362-4367
   Abstract »    Full Text »    PDF »
Mg2+-Induced Compaction of Single RNA Molecules Monitored by Tethered Particle Microscopy.
M. Newby Lambert, E. Vocker, S. Blumberg, S. Redemann, A. Gajraj, J.-C. Meiners, and N. G. Walter (2006)
Biophys. J. 90, 3672-3685
   Abstract »    Full Text »    PDF »
Translational Control of Cytochrome c by RNA-Binding Proteins TIA-1 and HuR.
T. Kawai, A. Lal, X. Yang, S. Galban, K. Mazan-Mamczarz, and M. Gorospe (2006)
Mol. Cell. Biol. 26, 3295-3307
   Abstract »    Full Text »    PDF »
Non-coding RNA..
J. S. Mattick and I. V. Makunin (2006)
Hum. Mol. Genet. 15, R17-R29
   Abstract »    Full Text »    PDF »
RNA granules.
P. Anderson and N. Kedersha (2006)
J. Cell Biol. 172, 803-808
   Abstract »    Full Text »    PDF »
Standing guard: Perinuclear localization of an RNA-dependent RNA polymerase.
W. G. Kelly (2006)
PNAS 103, 2007-2008
   Full Text »    PDF »
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.
I. Kashima, A. Yamashita, N. Izumi, N. Kataoka, R. Morishita, S. Hoshino, M. Ohno, G. Dreyfuss, and S. Ohno (2006)
Genes & Dev. 20, 355-367
   Abstract »    Full Text »    PDF »
Metazoan oocyte and early embryo development program: a progression through translation regulatory cascades.
S. Vasudevan, E. Seli, and J. A. Steitz (2006)
Genes & Dev. 20, 138-146
   Full Text »    PDF »
NAB1 Is an RNA Binding Protein Involved in the Light-Regulated Differential Expression of the Light-Harvesting Antenna of Chlamydomonas reinhardtii.
J. H. Mussgnug, L. Wobbe, I. Elles, C. Claus, M. Hamilton, A. Fink, U. Kahmann, A. Kapazoglou, C. W. Mullineaux, M. Hippler, et al. (2005)
PLANT CELL 17, 3409-3421
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)