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Science 26 March 2004:
Vol. 303. no. 5666, pp. 2019 - 2022
DOI: 10.1126/science.1093137
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Reports

Envelope-Constrained Neutralization-Sensitive HIV-1 After Heterosexual Transmission

Cynthia A. Derdeyn,1,7 Julie M. Decker,3 Frederic Bibollet-Ruche,2,7 John L. Mokili,4 Mark Muldoon,5 Scott A. Denham,1 Marintha L. Heil,1 Francis Kasolo,8 Rosemary Musonda,9 Beatrice H. Hahn,1,2,7 George M. Shaw,1,2,3,7 Bette T. Korber,4,10 Susan Allen,6,7 Eric Hunter1,7*

Heterosexual transmission accounts for the majority of human immunodeficiency virus–1 (HIV-1) infections worldwide, yet the viral properties that determine transmission fitness or outgrowth have not been elucidated. Here we show, for eight heterosexual transmission pairs, that recipient viruses were monophyletic, encoding compact, glycan-restricted envelope glycoproteins. These viruses were also uniquely sensitive to neutralization by antibody from the transmitting partner. Thus, the exposure of neutralizing epitopes, which are lost in chronic infection because of immune escape, appears to be favored in the newly infected host. This reveals characteristics of the envelope glycoprotein that influence HIV-1 transmission and may have implications for vaccine design.

1 Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 USA.
2 Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 USA.
3 Howard Hughes Medical Institute, University of Alabama at Birmingham, Birmingham, AL 35294 USA.
4 HIV Sequence Database, Los Alamos National Laboratory, Los Alamos, NM 87544, USA.
5 Department of Mathematics, University of Manchester Institute of Science and Technology, Manchester, UK.
6 Department of Epidemiology and International Health, School of Public Health; University of Alabama at Birmingham, Birmingham, AL 35294, USA.
7 University of Alabama at Birmingham Center for AIDS Research; University of Alabama at Birmingham, Birmingham, AL 35294, USA.
8 Department of Pathology and Microbiology, University Teaching Hospital, Lusaka, Zambia.
9 Tropical Disease Research Center, Ndola, Zambia.
10 Santa Fe Institute, Santa Fe, NM 87501, USA.

* To whom correspondence should be addressed. E-mail: ehunter{at}uab.edu

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Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection.
S. D. W. Frost, T. Wrin, D. M. Smith, S. L. K. Pond, Y. Liu, E. Paxinos, C. Chappey, J. Galovich, J. Beauchaine, C. J. Petropoulos, et al. (2005)
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Y. Shi, E. Brandin, E. Vincic, M. Jansson, A. Blaxhult, K. Gyllensten, L. Moberg, C. Brostrom, E. M. Fenyo, and J. Albert (2005)
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Human Immunodeficiency Virus Type 1 Variants Isolated from Single Plasma Samples Display a Wide Spectrum of Neutralization Sensitivity.
K. Skrabal, S. Saragosti, J.-L. Labernardiere, F. Barin, F. Clavel, and F. Mammano (2005)
J. Virol. 79, 11848-11857
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J. R. Mascola, P. D'Souza, P. Gilbert, B. H. Hahn, N. L. Haigwood, L. Morris, C. J. Petropoulos, V. R. Polonis, M. Sarzotti, and D. C. Montefiori (2005)
J. Virol. 79, 10103-10107
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Human Immunodeficiency Virus Type 1 env Clones from Acute and Early Subtype B Infections for Standardized Assessments of Vaccine-Elicited Neutralizing Antibodies.
M. Li, F. Gao, J. R. Mascola, L. Stamatatos, V. R. Polonis, M. Koutsoukos, G. Voss, P. Goepfert, P. Gilbert, K. M. Greene, et al. (2005)
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P. Rusert, H. Kuster, B. Joos, B. Misselwitz, C. Gujer, C. Leemann, M. Fischer, G. Stiegler, H. Katinger, W. C. Olson, et al. (2005)
J. Virol. 79, 8454-8469
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Biologic and Genetic Characterization of a Panel of 60 Human Immunodeficiency Virus Type 1 Isolates, Representing Clades A, B, C, D, CRF01_AE, and CRF02_AG, for the Development and Assessment of Candidate Vaccines.
B. K. Brown, J. M. Darden, S. Tovanabutra, T. Oblander, J. Frost, E. Sanders-Buell, M. S. de Souza, D. L. Birx, F. E. McCutchan, and V. R. Polonis (2005)
J. Virol. 79, 6089-6101
   Abstract »    Full Text »    PDF »
Characterization of Human Immunodeficiency Virus Type 1 (HIV-1) Envelope Variation and Neutralizing Antibody Responses during Transmission of HIV-1 Subtype B.
S. D. W. Frost, Y. Liu, S. L. K. Pond, C. Chappey, T. Wrin, C. J. Petropoulos, S. J. Little, and D. D. Richman (2005)
J. Virol. 79, 6523-6527
   Abstract »    Full Text »    PDF »
Selection for Human Immunodeficiency Virus Type 1 Envelope Glycosylation Variants with Shorter V1-V2 Loop Sequences Occurs during Transmission of Certain Genetic Subtypes and May Impact Viral RNA Levels.
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J. Virol. 79, 6528-6531
   Abstract »    Full Text »    PDF »
Antigenic conservation and immunogenicity of the HIV coreceptor binding site.
J. M. Decker, F. Bibollet-Ruche, X. Wei, S. Wang, D. N. Levy, W. Wang, E. Delaporte, M. Peeters, C. A. Derdeyn, S. Allen, et al. (2005)
J. Exp. Med. 201, 1407-1419
   Abstract »    Full Text »    PDF »
Retroviral Recombination In Vivo: Viral Replication Patterns and Genetic Structure of Simian Immunodeficiency Virus (SIV) Populations in Rhesus Macaques after Simultaneous or Sequential Intravaginal Inoculation with SIVmac239{Delta}vpx/{Delta}vpr and SIVmac239{Delta}nef.
E.-Y. Kim, M. Busch, K. Abel, L. Fritts, P. Bustamante, J. Stanton, D. Lu, S. Wu, J. Glowczwskie, T. Rourke, et al. (2005)
J. Virol. 79, 4886-4895
   Abstract »    Full Text »    PDF »
Semen-Specific Genetic Characteristics of Human Immunodeficiency Virus Type 1 env.
S. K. Pillai, B. Good, S. K. Pond, J. K. Wong, M. C. Strain, D. D. Richman, and D. M. Smith (2005)
J. Virol. 79, 1734-1742
   Abstract »    Full Text »    PDF »
Multiple V1/V2 env Variants Are Frequently Present during Primary Infection with Human Immunodeficiency Virus Type 1.
K. Ritola, C. D. Pilcher, S. A. Fiscus, N. G. Hoffman, J. A. E. Nelson, K. M. Kitrinos, C. B. Hicks, J. J. Eron Jr., and R. Swanstrom (2004)
J. Virol. 78, 11208-11218
   Abstract »    Full Text »    PDF »


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