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Realizing the Potential of the Genome Revolution: The Genomes to Life Program
Marvin E. Frazier,1Gary M. Johnson,2David G. Thomassen,1*Carl E. Oliver,2Aristides Patrinos1
The systems biology revolution is proceeding along
multiple pathways as different science agencies and the private sectorhave adopted strategies suited to their particular needs and cultures.To meet this challenge, the U.S. Department of Energy has developedthe
Genomes to Life (GTL) program. A central focus of GTL is environmentalmicrobial biology as a way to approach global environmental problems,and its key goal is to achieve, over the next 10 to 20 years,a basic
understanding of thousands of microbes and microbial systemsin their
native environments. This focus demands that we addresshuge gaps in
knowledge, technology, computing, data storage andmanipulation, and
systems-level integration.
1 U.S. Department of Energy, Office of Science,
Office of Biological and Environmental Research, SC-70,
2 Office of Advanced Scientific Computing Research,
SC-30, Germantown Building, 1000 Independence Avenue, S.W., Washington,
DC 20585-1290, USA.
*
To whom correspondence should be addressed. E-mail:
david.thomassen{at}science.doe.gov
Pooled ORF Expression Technology (POET): Using Proteomics to Screen Pools of Open Reading Frames for Protein Expression.
W. K. Gillette, D. Esposito, P. H. Frank, M. Zhou, L.-R. Yu, C. Jozwik, X. Zhang, B. McGowan, D. M. Jacobowitz, H. B. Pollard, et al. (2005)
Mol. Cell. Proteomics
4, 1647-1652
|Abstract »|Full Text »|PDF »
Global profiling of Shewanella oneidensis MR-1: Expression of hypothetical genes and improved functional annotations.
E. Kolker, A. F. Picone, M. Y. Galperin, M. F. Romine, R. Higdon, K. S. Makarova, N. Kolker, G. A. Anderson, X. Qiu, K. J. Auberry, et al. (2005)
PNAS
102, 2099-2104
|Abstract »|Full Text »|PDF »
Identification and functional analysis of 'hypothetical' genes expressed in Haemophilus influenzae.
E. Kolker, K. S. Makarova, S. Shabalina, A. F. Picone, S. Purvine, T. Holzman, T. Cherny, D. Armbruster, R. S. Munson Jr, G. Kolesov, et al. (2004)
Nucleic Acids Res.
32, 2353-2361
|Abstract »|Full Text »|PDF »
