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Science 4 April 2003: Vol. 300. no. 5616, pp. 96 - 100 DOI: 10.1126/science.1082830
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Review
Visualizing Signals Moving in Cells
Cornelis J. Weijer
Cells display a highly complex spatiotemporal
organization, required to exert a wide variety of different functions,
for example, detection, processing, and propagation of nerve impulses
by neurons; contraction and relaxation by muscle cells; movement by
leukocytes; and adsorption and secretion of nutrients and metabolites
by epithelial cells lining the gut. Successful execution of these
complex processes requires highly dynamic information transfer between
different regions and compartments within cells. Through the
development of fluorescent sensors for intracellular signaling
molecules coupled with improved microscopic imaging techniques, it has
now become possible to investigate signal propagation in cells with
high spatial and temporal resolution.
School of Life Sciences, University of Dundee, Wellcome Trust
Biocentre, Dundee DD1 5EH, UK. E-mail: c.j.weijer{at}dundee.ac.uk
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