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Cells display a highly complex spatiotemporal
organization, required to exert a wide variety of different functions,
for example,detection, processing, and propagation of nerve impulses
by neurons;contraction and relaxation by muscle cells; movement by
leukocytes;and adsorption and secretion of nutrients and metabolites
by epithelialcells lining the gut. Successful execution of these
complex processesrequires highly dynamic information transfer between
differentregions and compartments within cells. Through the
developmentof fluorescent sensors for intracellular signaling
molecules coupledwith improved microscopic imaging techniques, it has
now becomepossible to investigate signal propagation in cells with
highspatial and temporal resolution.
School of Life Sciences, University of Dundee, Wellcome Trust
Biocentre, Dundee DD1 5EH, UK. E-mail: c.j.weijer{at}dundee.ac.uk
Daniel Zicha, Ian M. Dobbie, Mark R. Holt, James Monypenny, Daniel Y. H. Soong, Colin Gray, and Graham A. Dunn (4 April 2003) Science300 (5616), 142.
[DOI: 10.1126/science.1082026] |Abstract »|Full Text »|PDF »|Supporting Online Material »
PERSPECTIVES
Paul Martin and Susan M. Parkhurst (4 April 2003) Science300 (5616), 63.
[DOI: 10.1126/science.1084148] |Summary »|Full Text »|PDF »
INTRODUCTION TO SPECIAL ISSUE
Stella M. Hurtley and Laura Helmuth (4 April 2003) Science300 (5616), 75.
[DOI: 10.1126/science.300.5616.75] |Summary »|PDF »
NEWS
Mary Beckman (4 April 2003) Science300 (5616), 76.
[DOI: 10.1126/science.300.5616.76] |Summary »|Full Text »|PDF »
NEWS
Greg Miller (4 April 2003) Science300 (5616), 78.
[DOI: 10.1126/science.300.5616.78] |Summary »|Full Text »|PDF »
NEWS
Caroline Seydel (4 April 2003) Science300 (5616), 80.
[DOI: 10.1126/science.300.5616.80] |Summary »|Full Text »|PDF »
Characterization and application of single fluorescent nanodiamonds as cellular biomarkers.
C.-C. Fu, H.-Y. Lee, K. Chen, T.-S. Lim, H.-Y. Wu, P.-K. Lin, P.-K. Wei, P.-H. Tsao, H.-C. Chang, and W. Fann (2007)
PNAS
104, 727-732
|Abstract »|Full Text »|PDF »
Paxillin is required for cell-substrate adhesion, cell sorting and slug migration during Dictyostelium development.
T. Bukahrova, G. Weijer, L. Bosgraaf, D. Dormann, P. J. van Haastert, and C. J. Weijer (2005)
J. Cell Sci.
118, 4295-4310
|Abstract »|Full Text »|PDF »
Intravital multiphoton microscopy of dynamic renal processes.
B. A. Molitoris and R. M. Sandoval (2005)
Am J Physiol Renal Physiol
288, F1084-F1089
|Abstract »|Full Text »|PDF »
A general approach for chemical labeling and rapid, spatially controlled protein inactivation.
Roles of the Proline-rich Domain in SLP-76 Subcellular Localization and T Cell Function.
A. L. Singer, S. C. Bunnell, A. E. Obstfeld, M. S. Jordan, J. N. Wu, P. S. Myung, L. E. Samelson, and G. A. Koretzky (2004)
J. Biol. Chem.
279, 15481-15490
|Abstract »|Full Text »|PDF »
