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Science 4 April 2003:
Vol. 300. no. 5616, pp. 91 - 96
DOI: 10.1126/science.1082177
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Review

Mitosis Through the Microscope: Advances in Seeing Inside Live Dividing Cells

Conly L. Rieder,* Alexey Khodjakov*

The most visually spectacular events in the life of a cell occur when it divides. This is especially true in higher eukaryotes, where the size and geometry of cells allow the division process to be followed through a microscope with considerable clarity. In these organisms, the membrane surrounding the nucleus breaks down after the replicated DNA has condensed to form discrete chromosomes. Several new structures are then assembled to separate the chromosomes and partition the cytoplasm into two separate cells.

Lab of Cell Regulation, Division of Molecular Medicine, Wadsworth Center, Albany, NY 12201-0509, USA. Department of Biomedical Sciences, State University of New York, Albany, NY 12222, USA. Marine Biology Laboratory, Woods Hole, MA 02543, USA.
*   To whom correspondence should be addressed. Molecular Medicine, Wadsworth Center, Post Office Box 509, Albany, NY 12201-0509, USA. E-mail: rieder{at}wadsworth.org, khodj{at}wadsworth.org

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