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In its earliest clinical phase, Alzheimer's disease
characteristically produces a remarkably pure impairment of memory.
Mountingevidence suggests that this syndrome begins with subtle
alterationsof hippocampal synaptic efficacy prior to frank neuronal
degeneration,and that the synaptic dysfunction is caused by diffusible
oligomericassemblies of the amyloid protein.
Center for Neurologic Diseases, Brigham and Women's Hospital, and
the Harvard Center for Neurodegeneration and Repair, Boston, MA 02115, USA. E-mail: selkoe{at}cnd.bwh.harvard.edu
The editors suggest the following Related Resources on Science sites:
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Peter Stern (25 October 2002) Science298 (5594), 769.
[DOI: 10.1126/science.298.5594.769] |Summary »|PDF »
REVIEW
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Morgan Sheng and Myung Jong Kim (25 October 2002) Science298 (5594), 776.
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VIEWPOINT
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[DOI: 10.1126/science.1076386] |Abstract »|Full Text »|PDF »
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D. Rossi, L. Brambilla, C. F. Valori, A. Crugnola, G. Giaccone, R. Capobianco, M. Mangieri, A. E. Kingston, A. Bloc, P. Bezzi, et al. (2005)
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Soluble {beta}-Amyloid1-40 Induces NMDA-Dependent Degradation of Postsynaptic Density-95 at Glutamatergic Synapses.
F. Roselli, M. Tirard, J. Lu, P. Hutzler, P. Lamberti, P. Livrea, M. Morabito, and O. F. X. Almeida (2005)
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|Abstract »|Full Text »|PDF »
Brain Microarray: Finding Needles in Molecular Haystacks.
N. M. Lewandowski and S. A. Small (2005)
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25, 10341-10346
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{beta}-Amyloid Immunotherapy Prevents Synaptic Degeneration in a Mouse Model of Alzheimer's Disease.
M. Buttini, E. Masliah, R. Barbour, H. Grajeda, R. Motter, K. Johnson-Wood, K. Khan, P. Seubert, S. Freedman, D. Schenk, et al. (2005)
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APOE related alterations in cerebral activation even at college age.
N Scarmeas, C G Habeck, J Hilton, K E Anderson, J Flynn, A Park, and Y Stern (2005)
J. Neurol. Neurosurg. Psychiatry
76, 1440-1444
|Abstract »|Full Text »|PDF »
Neuritogenesis and neuronal differentiation promoted by 2,4-dinitrophenol, a novel anti-amyloidogenic compound.
A. P. Wasilewska-Sampaio, M. S. Silveira, O. Holub, R. Goecking, F. C. A. Gomes, V. M. Neto, R. Linden, S. T. Ferreira, and F. G. De Felice (2005)
FASEB J
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|Abstract »|Full Text »|PDF »
{beta}-Amyloid-induced Dynamin 1 Depletion in Hippocampal Neurons: A POTENTIAL MECHANISM FOR EARLY COGNITIVE DECLINE IN ALZHEIMER DISEASE.
B. L. Kelly, R. Vassar, and A. Ferreira (2005)
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280, 31746-31753
|Abstract »|Full Text »|PDF »
Protofibril Formation of Amyloid {beta}-Protein at Low pH via a Non-cooperative Elongation Mechanism.
R. Carrotta, M. Manno, D. Bulone, V. Martorana, and P. L. S. Biagio (2005)
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280, 30001-30008
|Abstract »|Full Text »|PDF »
Specific inhibition of CBP/{beta}-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation.
J.-L. Teo, H. Ma, C. Nguyen, C. Lam, and M. Kahn (2005)
PNAS
102, 12171-12176
|Abstract »|Full Text »|PDF »
Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD.
B. C. Dickerson, D. H. Salat, D. N. Greve, E. F. Chua, E. Rand-Giovannetti, D. M. Rentz, L. Bertram, K. Mullin, R. E. Tanzi, D. Blacker, et al. (2005)
Neurology
65, 404-411
|Abstract »|Full Text »|PDF »
Amyloid-{beta} Peptide Inhibits Activation of the Nitric Oxide/cGMP/cAMP-Responsive Element-Binding Protein Pathway during Hippocampal Synaptic Plasticity.
D. Puzzo, O. Vitolo, F. Trinchese, J. P. Jacob, A. Palmeri, and O. Arancio (2005)
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|Abstract »|Full Text »|PDF »
Age-Related Loss of Synaptophysin Immunoreactive Presynaptic Boutons within the Hippocampus of APP751SL, PS1M146L, and APP751SL/PS1M146L Transgenic Mice.
B. P.F. Rutten, N. M. Van der Kolk, S. Schafer, M. A.M.J. van Zandvoort, T. A. Bayer, H. W.M. Steinbusch, and C. Schmitz (2005)
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|Abstract »|Full Text »|PDF »
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