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Science 4 October 2002: Vol. 298. no. 5591, pp. 129 - 149 DOI: 10.1126/science.1076181
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Research Articles
The Genome Sequence of the Malaria Mosquito Anopheles gambiae
Robert A. Holt,1*
G. Mani Subramanian,1
Aaron Halpern,1
Granger G. Sutton,1
Rosane Charlab,1
Deborah R. Nusskern,1
Patrick Wincker,2
Andrew G. Clark,3
José M. C. Ribeiro,4
Ron Wides,5
Steven L. Salzberg,6
Brendan Loftus,6
Mark Yandell,1
William H. Majoros,16
Douglas B. Rusch,1
Zhongwu Lai,1
Cheryl L. Kraft,1
Josep F. Abril,7
Veronique Anthouard,2
Peter Arensburger,8
Peter W. Atkinson,8
Holly Baden,1
Veronique de Berardinis,2
Danita Baldwin,1
Vladimir Benes,9
Jim Biedler,10
Claudia Blass,9
Randall Bolanos,1
Didier Boscus,2
Mary Barnstead,1
Shuang Cai,1
Angela Center,1
Kabir Chatuverdi,1
George K. Christophides,9
Mathew A. Chrystal,11
Michele Clamp,12
Anibal Cravchik,1
Val Curwen,12
Ali Dana,11
Art Delcher,1
Ian Dew,1
Cheryl A. Evans,1
Michael Flanigan,1
Anne Grundschober-Freimoser,13
Lisa Friedli,8
Zhiping Gu,1
Ping Guan,1
Roderic Guigo,7
Maureen E. Hillenmeyer,11
Susanne L. Hladun,1
James R. Hogan,11
Young S. Hong,11
Jeffrey Hoover,1
Olivier Jaillon,2
Zhaoxi Ke,111
Chinnappa Kodira,1
Elena Kokoza,14
Anastasios Koutsos,1516
Ivica Letunic,9
Alex Levitsky,1
Yong Liang,1
Jhy-Jhu Lin,16
Neil F. Lobo,11
John R. Lopez,1
Joel A. Malek,6
Tina C. McIntosh,1
Stephan Meister,9
Jason Miller,1
Clark Mobarry,1
Emmanuel Mongin,17
Sean D. Murphy,1
David A. O'Brochta,13
Cynthia Pfannkoch,1
Rong Qi,1
Megan A. Regier,1
Karin Remington,1
Hongguang Shao,10
Maria V. Sharakhova,11
Cynthia D. Sitter,1
Jyoti Shetty,6
Thomas J. Smith,1
Renee Strong,1
Jingtao Sun,1
Dana Thomasova,9
Lucas Q. Ton,11
Pantelis Topalis,15
Zhijian Tu,10
Maria F. Unger,11
Brian Walenz,1
Aihui Wang,1
Jian Wang,1
Mei Wang,1
Xuelan Wang,11§
Kerry J. Woodford,1
Jennifer R. Wortman,16
Martin Wu,6
Alison Yao,1
Evgeny M. Zdobnov,9
Hongyu Zhang,1
Qi Zhao,1
Shaying Zhao,6
Shiaoping C. Zhu,1
Igor Zhimulev,14
Mario Coluzzi,18
Alessandra della Torre,18
Charles W. Roth,19
Christos Louis,1516
Francis Kalush,1
Richard J. Mural,1
Eugene W. Myers,1
Mark D. Adams,1
Hamilton O. Smith,1
Samuel Broder,1
Malcolm J. Gardner,6
Claire M. Fraser,6
Ewan Birney,17
Peer Bork,9
Paul T. Brey,19
J. Craig Venter,16
Jean Weissenbach,2
Fotis C. Kafatos,9
Frank H. Collins,11
Stephen L. Hoffman1
Anopheles gambiae is the principal vector
of malaria, a disease that afflicts more than 500 million people and
causes more than 1 million deaths each year. Tenfold shotgun sequence
coverage was obtained from the PEST strain of A. gambiae and
assembled into scaffolds that span 278 million base pairs. A total of
91% of the genome was organized in 303 scaffolds; the largest scaffold was 23.1 million base pairs. There was substantial genetic variation within this strain, and the apparent existence of two haplotypes of
approximately equal frequency ("dual haplotypes") in a substantial fraction of the genome likely reflects the outbred nature of the PEST
strain. The sequence produced a conservative inference of more than
400,000 single-nucleotide polymorphisms that showed a markedly bimodal
density distribution. Analysis of the genome sequence revealed strong
evidence for about 14,000 protein-encoding transcripts. Prominent
expansions in specific families of proteins likely involved in cell
adhesion and immunity were noted. An expressed sequence tag analysis of
genes regulated by blood feeding provided insights into the
physiological adaptations of a hematophagous insect.
1 Celera Genomics, 45 West Gude Drive,
Rockville, MD 20850, USA.
2 Genoscope/Centre
National de Sequencage and CNRS-UMR 8030, 2 rue Gaston Cremieux, 91057 Evry Cedex 06, France.
3 Molecular Biology and
Genetics, Cornell University, Ithaca, NY 14853, USA.
4 Laboratory of Malaria and Vector Research,
National Institute of Allergy and Infectious Diseases (NIAID), Building
4, Room 126, 4 Center Drive, MSC-0425, Bethesda, MD 20892, USA.
5 Faculty of Life Sciences, Bar-Ilan University,
Ramat-Gan, Israel.
6 The Institute for Genomic
Research (TIGR), 9712 Medical Center Drive, Rockville, MD 20850, USA.
7 Grup de Recerca en Informatica Biomedica,
IMIM/UPF/CRG, Barcelona, Catalonia, Spain.
8 Department of Entomology, University of
California, Riverside, CA 92521, USA.
9 European
Molecular Biology Laboratory, Meyerhofstr. 1, 69117 Heidelberg,
Germany.
10 Virginia Polytechnic Institute and
State University, Blacksburg, VA 24061, USA.
11 Center for Tropical Disease Research and
Training, University of Notre Dame, Galvin Life Sciences Building,
Notre Dame, IN 46556, USA.
12 Wellcome Trust Sanger
Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA,
UK.
13 Center for Agricultural Biotechnology,
University of Maryland Biotechnology Institute, College Park, MD 20742, USA.
14 Institute of Cytology and Genetics,
Lavrentyeva ave 10, Novosibirsk 630090, Russia.
15 Institute of Molecular Biology and Biotechnology
of the Foundation of Research and Technology-Hellas (IMBB-FORTH), Post
Office Box 1527, GR-711 10 Heraklion, Crete, Greece, and University of
Crete, GR-711 10 Heraklion, Crete, Greece.
16 Department of Biology, University of Crete,
GR-711 10 Heraklion, Crete, Greece.
17 European
Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton,
Cambridge CB10 1SD, UK.
18 Dipartimento di Scienze
di Sanità Pubblica, Sezione di Parassitologia, Università
degli Studi di Roma "La Sapienza," P.le Aldo Moro 5, 00185 Roma,
Italy.
19 Unité de Biochimie et Biologie
Moléculaire des Insectes, Institut Pasteur, Paris 75724 Cedex 15, France.
*
Present address: Canada's Michael Smith Genome Science Centre,
British Columbia Cancer Agency, Room 3427, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada.
Present address: Agencourt Bioscience Corporation,
100 Cummings Center, Suite 107J, Beverly, MA 01915, USA.
§
Present address: Department of Pharmacology, Sun
Yat-Sen Medical School, Sun Yat-Sen University #74, Zhongshan 2nd Road,
Guangzhou (Canton), 510089, P. R. China.
Present address: Sanaria, 308 Argosy Drive, Gaithersburg, MD
20878, USA.
To whom correspondence should be addressed. E-mail:
robert.holt{at}celera.com, rholt{at}bcgsc.ca (R.A.H.),
frank.h.collins.75{at}nd.edu (F.H.C.).
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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- Y. T. Qiu, J. J.A. van Loon, W. Takken, J. Meijerink, and H. M. Smid (2006)
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31, 845-863
| Abstract »
| Full Text »
| PDF »
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- N. Kaplan and M. Linial (2006)
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16, 1431-1438
| Abstract »
| Full Text »
| PDF »
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- P. K. Dearden, M. J. Wilson, L. Sablan, P. W. Osborne, M. Havler, E. McNaughton, K. Kimura, N. V. Milshina, M. Hasselmann, T. Gempe, et al. (2006)
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16, 1376-1384
| Abstract »
| Full Text »
| PDF »
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- J. Savard, D. Tautz, S. Richards, G. M. Weinstock, R. A. Gibbs, J. H. Werren, H. Tettelin, and M. J. Lercher (2006)
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16, 1334-1338
| Abstract »
| Full Text »
| PDF »
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- K. L. McElroy, K. A. Tsetsarkin, D. L. Vanlandingham, and S. Higgs (2006)
J. Gen. Virol.
87, 2993-3001
| Abstract »
| Full Text »
| PDF »
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- A. K. Pullikuth, K. Aimanova, W. Kang'ethe, H. R. Sanders, and S. S. Gill (2006)
J. Exp. Biol.
209, 3529-3544
| Abstract »
| Full Text »
| PDF »
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- M. S. Thimgan, J. S. Berg, and A. E. Stuart (2006)
J. Exp. Biol.
209, 3383-3404
| Abstract »
| Full Text »
| PDF »
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- S. Waldrop, C.-C. Chan, T. Cagatay, S. Zhang, R. Rousset, J. Mack, W. Zeng, M. Fish, M. Zhang, M. Amanai, et al. (2006)
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174, 331-348
| Abstract »
| Full Text »
| PDF »
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- S. R. Schulze, B. F. McAllister, D. A. R. Sinclair, K. A. Fitzpatrick, M. Marchetti, S. Pimpinelli, and B. M. Honda (2006)
Genetics
173, 1433-1445
| Abstract »
| Full Text »
| PDF »
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Genome Res.
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| Abstract »
| Full Text »
| PDF »
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- J. Grassot, M. Gouy, G. Perriere, and G. Mouchiroud (2006)
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| Abstract »
| Full Text »
| PDF »
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- I. V. Sharakhov, B. J. White, M. V. Sharakhova, J. Kayondo, N. F. Lobo, F. Santolamazza, A. della Torre, F. Simard, F. H. Collins, and N. J. Besansky (2006)
PNAS
103, 6258-6262
| Abstract »
| Full Text »
| PDF »
- Evolution of exon-intron structure and alternative splicing in fruit flies and malarial mosquito genomes.
- D. B. Malko, V. J. Makeev, A. A. Mironov, and M. S. Gelfand (2006)
Genome Res.
16, 505-509
| Abstract »
| Full Text »
| PDF »
- Functional Conservation of the fruitless Male Sex-Determination Gene Across 250 Myr of Insect Evolution.
- D. A. Gailey, J.-C. Billeter, J. H. Liu, F. Bauzon, J. B. Allendorfer, and S. F. Goodwin (2006)
Mol. Biol. Evol.
23, 633-643
| Abstract »
| Full Text »
| PDF »
- Identifying neuropeptide and protein hormone receptors in Drosophila melanogaster by exploiting genomic data.
- F. Hauser, M. Williamson, G. Cazzamali, and C. J. P. Grimmelikhuijzen (2006)
Brief Funct Genomic Proteomic
4, 321-330
| Abstract »
| Full Text »
| PDF »
- Function and Evolution of a Mosquito Salivary Protein Family.
- E. Calvo, B. J. Mans, J. F. Andersen, and J. M. C. Ribeiro (2006)
J. Biol. Chem.
281, 1935-1942
| Abstract »
| Full Text »
| PDF »
- Stimulation of muscarinic receptors mimics experience-dependent plasticity in the honey bee brain.
- N. Ismail, G. E. Robinson, and S. E. Fahrbach (2006)
PNAS
103, 207-211
| Abstract »
| Full Text »
| PDF »
- Sequence and Comparative Genomic Analysis of Actin-related Proteins.
- J. Muller, Y. Oma, L. Vallar, E. Friederich, O. Poch, and B. Winsor (2005)
Mol. Biol. Cell
16, 5736-5748
| Abstract »
| Full Text »
| PDF »
- S-Phase-Dependent Enhancement of Dengue Virus 2 Replication in Mosquito Cells, but Not in Human Cells.
- A.-M. Helt and E. Harris (2005)
J. Virol.
79, 13218-13230
| Abstract »
| Full Text »
| PDF »
- The Origin and Evolution of Mosquito APE Retroposons.
- J. L. Crainey, C. F. Garvey, and C. A. Malcolm (2005)
Mol. Biol. Evol.
22, 2190-2197
| Abstract »
| Full Text »
| PDF »
- The Coevolution of Insect Muscle TpnT and TpnI Gene Isoforms.
- R. Herranz, J. Mateos, J. A. Mas, E. Garcia-Zaragoza, M. Cervera, and R. Marco (2005)
Mol. Biol. Evol.
22, 2231-2242
| Abstract »
| Full Text »
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- Realizing the Promise of Genomics in Biomedical Research.
- A. E. Guttmacher and F. S. Collins (2005)
JAMA
294, 1399-1402
| Full Text »
| PDF »
- Carbonic anhydrase in the adult mosquito midgut.
- M. del Pilar Corena, L. VanEkeris, Ma. I. Salazar, D. Bowers, M. M. Fiedler, D. Silverman, C. Tu, and P. J. Linser (2005)
J. Exp. Biol.
208, 3263-3273
| Abstract »
| Full Text »
| PDF »
- Mosquito natriuretic peptide identified as a calcitonin-like diuretic hormone in Anopheles gambiae (Giles).
- G. M. Coast, C. S. Garside, S. G. Webster, K. M. Schegg, and D. A. Schooley (2005)
J. Exp. Biol.
208, 3281-3291
| Abstract »
| Full Text »
| PDF »
- Immune signaling pathways regulating bacterial and malaria parasite infection of the mosquito Anopheles gambiae.
- S. Meister, S. M. Kanzok, X.-l. Zheng, C. Luna, T.-R. Li, N. T. Hoa, J. R. Clayton, K. P. White, F. C. Kafatos, G. K. Christophides, et al. (2005)
PNAS
102, 11420-11425
| Abstract »
| Full Text »
| PDF »
- Assembly of polymorphic genomes: Algorithms and application to Ciona savignyi.
- J. P. Vinson, D. B. Jaffe, K. O'Neill, E. K. Karlsson, N. Stange-Thomann, S. Anderson, J. P. Mesirov, N. Satoh, Y. Satou, C. Nusbaum, et al. (2005)
Genome Res.
15, 1127-1135
| Abstract »
| Full Text »
| PDF »
- Estimating the tempo and mode of gene family evolution from comparative genomic data.
- M. W. Hahn, T. De Bie, J. E. Stajich, C. Nguyen, and N. Cristianini (2005)
Genome Res.
15, 1153-1160
| Abstract »
| Full Text »
| PDF »
- Malaria in the post-genomics era: light at the end of the tunnel or just another train?.
- D L Gardiner, J S McCarthy, and K R Trenholme (2005)
Postgrad. Med. J.
81, 505-509
| Abstract »
| Full Text »
| PDF »
- A Cellular Drosophila melanogaster Protein with Similarity to Baculovirus F Envelope Fusion Proteins.
- O. Lung and G. W. Blissard (2005)
J. Virol.
79, 7979-7989
| Abstract »
| Full Text »
| PDF »
- Ultraconserved elements in insect genomes: A highly conserved intronic sequence implicated in the control of homothorax mRNA splicing.
- E. A. Glazov, M. Pheasant, E. A. McGraw, G. Bejerano, and J. S. Mattick (2005)
Genome Res.
15, 800-808
| Abstract »
| Full Text »
| PDF »
- AnoEST: Toward A. gambiae functional genomics.
- E. V. Kriventseva, A. C. Koutsos, C. Blass, F. C. Kafatos, G. K. Christophides, and E. M. Zdobnov (2005)
Genome Res.
15, 893-899
| Abstract »
| Full Text »
| PDF »
- Future Directions In Vaccines: The Payoffs Of Basic Research.
- S. Landry and C. Heilman (2005)
Health Aff.
24, 758-769
| Abstract »
| Full Text »
| PDF »
- The Repertoire of G-Protein-Coupled Receptors in Fully Sequenced Genomes.
- R. Fredriksson and H. B. Schioth (2005)
Mol. Pharmacol.
67, 1414-1425
| Abstract »
| Full Text »
| PDF »
- Evolution of Proteins and Gene Expression Levels are Coupled in Drosophila and are Independently Associated with mRNA Abundance, Protein Length, and Number of Protein-Protein Interactions.
- B. Lemos, B. R. Bettencourt, C. D. Meiklejohn, and D. L. Hartl (2005)
Mol. Biol. Evol.
22, 1345-1354
| Abstract »
| Full Text »
| PDF »
- REL1, a Homologue of Drosophila Dorsal, Regulates Toll Antifungal Immune Pathway in the Female Mosquito Aedes aegypti.
- S. W. Shin, V. Kokoza, G. Bian, H.-M. Cheon, Y. J. Kim, and A. S. Raikhel (2005)
J. Biol. Chem.
280, 16499-16507
| Abstract »
| Full Text »
| PDF »
- Identification of putative noncoding polyadenylated transcripts in Drosophila melanogaster.
- J. L. Tupy, A. M. Bailey, G. Dailey, M. Evans-Holm, C. W. Siebel, S. Misra, S. E. Celniker, and G. M. Rubin (2005)
PNAS
102, 5495-5500
| Abstract »
| Full Text »
| PDF »
- Comparing low coverage random shotgun sequence data from Brassica oleracea and Oryza sativa genome sequence for their ability to add to the annotation of Arabidopsis thaliana.
- M. S. Katari, V. Balija, R. K. Wilson, R. A. Martienssen, and W. R. McCombie (2005)
Genome Res.
15, 496-504
| Abstract »
| Full Text »
| PDF »
- Using shared genomic synteny and shared protein functions to enhance the identification of orthologous gene pairs.
- X. H. Zheng, F. Lu, Z.-Y. Wang, F. Zhong, J. Hoover, and R. Mural (2005)
Bioinformatics
21, 703-710
| Abstract »
| Full Text »
| PDF »
- Biosynthesis and secretion of insect lipoprotein: involvement of furin in cleavage of the apoB homolog, apolipophorin-II/I.
- M. M. W. Smolenaars, M. A. M. Kasperaitis, P. E. Richardson, K. W. Rodenburg, and D. J. Van der Horst (2005)
J. Lipid Res.
46, 412-421
| Abstract »
| Full Text »
| PDF »
- Drosophila N-cadherin functions in the first stage of the two-stage layer-selection process of R7 photoreceptor afferents.
- C.-Y. Ting, S. Yonekura, P. Chung, S.-n. Hsu, H. M. Robertson, A. Chiba, and C.-H. Lee (2005)
Development
132, 953-963
| Abstract »
| Full Text »
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- Sex-Linked Differentiation Between Incipient Species of Anopheles gambiae.
- A. D. Stump, J. A. Shoener, C. Costantini, N. Sagnon, and N. J. Besansky (2005)
Genetics
169, 1509-1519
| Abstract »
| Full Text »
| PDF »
- Complex early genes.
- S. W. Roy and W. Gilbert (2005)
PNAS
102, 1986-1991
| Abstract »
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- An Active Transposable Element, Herves, From the African Malaria Mosquito Anopheles gambiae.
- P. Arensburger, Y.-J. Kim, J. Orsetti, C. Aluvihare, D. A. O'Brochta, and P. W. Atkinson (2005)
Genetics
169, 697-708
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