Related Content
Search Google Scholar for:
More Information
Related Jobs from ScienceCareers
|
|
Science 15 March 2002: Vol. 295. no. 5562, pp. 2091 - 2094 DOI: 10.1126/science.1067467
|
|
Reports
Reverse Transcriptase-Mediated Tropism Switching in Bordetella Bacteriophage
Minghsun Liu,1
Rajendar Deora,1*
Sergei R. Doulatov,1*
Mari Gingery,1
Frederick A. Eiserling,1
Andrew Preston,2
Duncan J. Maskell,2
Robert W. Simons,1
Peggy A. Cotter,3
Julian Parkhill,4
Jeff F. Miller1
Host-pathogen interactions are often driven by mechanisms that
promote genetic variability. We have identified a group of temperate
bacteriophages that generate diversity in a gene, designated mtd (major tropism determinant), which specifies tropism for
receptor molecules on host Bordetella species. Tropism
switching is the result of a template-dependent, reverse
transcriptase-mediated process that introduces nucleotide
substitutions at defined locations within mtd. This
cassette-based mechanism is capable of providing a vast repertoire of
potential ligand-receptor interactions.
1 Department of Microbiology, Immunology and
Molecular Genetics, University of California, Los Angeles, Los Angeles,
CA 90095, USA.
2 Centre for Veterinary Science,
Department of Clinical Veterinary Medicine, University of Cambridge,
Cambridge CB3 OES, UK.
3 Department of Molecular,
Cellular and Developmental Biology, University of California, Santa
Barbara, Santa Barbara, CA 93106, USA.
4 The Sanger
Centre, The Wellcome Trust Genome Campus, Hixton, Cambridge, UK.
*
These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail:
jfmiller{at}ucla.edu.
Read the Full Text
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Genomics of Actinobacteria: Tracing the Evolutionary History of an Ancient Phylum.
- M. Ventura, C. Canchaya, A. Tauch, G. Chandra, G. F. Fitzgerald, K. F. Chater, and D. van Sinderen (2007)
Microbiol. Mol. Biol. Rev.
71, 495-548
| Abstract »
| Full Text »
| PDF »
- Comparative genomic analysis of mycobacteriophage Tweety: evolutionary insights and construction of compatible site-specific integration vectors for mycobacteria.
- T. T. Pham, D. Jacobs-Sera, M. L. Pedulla, R. W. Hendrix, and G. F. Hatfull (2007)
Microbiology
153, 2711-2723
| Abstract »
| Full Text »
| PDF »
- Dispersing biofilms with engineered enzymatic bacteriophage.
- T. K. Lu and J. J. Collins (2007)
PNAS
104, 11197-11202
| Abstract »
| Full Text »
| PDF »
- Prophage-Like Elements in Bifidobacteria: Insights from Genomics, Transcription, Integration, Distribution, and Phylogenetic Analysis.
- M. Ventura, J.-H. Lee, C. Canchaya, R. Zink, S. Leahy, J. A. Moreno-Munoz, M. O'Connell-Motherway, D. Higgins, G. F. Fitzgerald, D. J. O'Sullivan, et al. (2005)
Appl. Envir. Microbiol.
71, 8692-8705
| Abstract »
| Full Text »
| PDF »
- Self-limiting nature of seasonal cholera epidemics: Role of host-mediated amplification of phage.
- S. M. Faruque, M. J. Islam, Q. S. Ahmad, A. S. G. Faruque, D. A. Sack, G. B. Nair, and J. J. Mekalanos (2005)
PNAS
102, 6119-6124
| Abstract »
| Full Text »
| PDF »
- Type V Protein Secretion Pathway: the Autotransporter Story.
- I. R. Henderson, F. Navarro-Garcia, M. Desvaux, R. C. Fernandez, and D. Ala'Aldeen (2004)
Microbiol. Mol. Biol. Rev.
68, 692-744
| Abstract »
| Full Text »
| PDF »
- The Two Murein Lipoproteins of Salmonella enterica Serovar Typhimurium Contribute to the Virulence of the Organism.
- J. Sha, A. A. Fadl, G. R. Klimpel, D. W. Niesel, V. L. Popov, and A. K. Chopra (2004)
Infect. Immun.
72, 3987-4003
| Abstract »
| Full Text »
| PDF »
- Phage-Host Interaction: an Ecological Perspective.
- S. Chibani-Chennoufi, A. Bruttin, M.-L. Dillmann, and H. Brussow (2004)
J. Bacteriol.
186, 3677-3686
| Full Text »
| PDF »
- Genomic and Genetic Analysis of Bordetella Bacteriophages Encoding Reverse Transcriptase-Mediated Tropism-Switching Cassettes.
- M. Liu, M. Gingery, S. R. Doulatov, Y. Liu, A. Hodes, S. Baker, P. Davis, M. Simmonds, C. Churcher, K. Mungall, et al. (2004)
J. Bacteriol.
186, 1503-1517
| Abstract »
| Full Text »
| PDF »
- Alcaligin Siderophore Production by Bordetella bronchiseptica Strain RB50 Is Not Repressed by the BvgAS Virulence Control System.
- T. J. Brickman and S. K. Armstrong (2002)
J. Bacteriol.
184, 7055-7057
| Abstract »
| Full Text »
| PDF »
|
|