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Originally published in Science Express on 1 March 2001
Science 23 March 2001:
Vol. 291. no. 5512, pp. 2413 - 2417
DOI: 10.1126/science.1058867
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Reports

Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

David Masopust, Vaiva Vezys, Amanda L. Marzo, Leo Lefrançois*

Many intracellular pathogens infect a broad range of host tissues, but the importance of T cells for immunity in these sites is unclear because most of our understanding of antimicrobial T cell responses comes from analyses of lymphoid tissue. Here, we show that in response to viral or bacterial infection, antigen-specific CD8 T cells migrated to nonlymphoid tissues and were present as long-lived memory cells. Strikingly, CD8 memory T cells isolated from nonlymphoid tissues exhibited effector levels of lytic activity directly ex vivo, in contrast to their splenic counterparts. These results point to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection.

Division of Immunology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.
*   To whom correspondence should be addressed. E-mail: llefranc{at}neuron.uchc.edu

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   Abstract »    Full Text »    PDF »
Unique Ability of Activated CD4+ T Cells but Not Rested Effectors to Migrate to Non-lymphoid Sites in the Absence of Inflammation.
J. N. Agrewala, D. M. Brown, N. M. Lepak, D. Duso, G. Huston, and S. L. Swain (2007)
J. Biol. Chem. 282, 6106-6115
   Abstract »    Full Text »    PDF »
Increased CD8+ central memory T cells in patients with multiple sclerosis.
G.-Z. Liu, L.-B. Fang, P. Hjelmstrom, and X.-G. Gao (2007)
Multiple Sclerosis 13, 149-155
   Abstract »    PDF »
Interleukin-1 Receptor Type 1 Is Essential for Control of Cerebral but Not Systemic Listeriosis.
M. Deckert, S. Virna, M. Sakowicz-Burkiewicz, S. Lutjen, S. Soltek, H. Bluethmann, and D. Schluter (2007)
Am. J. Pathol. 170, 990-1002
   Abstract »    Full Text »    PDF »
Virus-Specific CD8+ T Cells in the Liver: Armed and Ready to Kill.
R. Keating, W. Yue, J. A. Rutigliano, J. So, E. Olivas, P. G. Thomas, and P. C. Doherty (2007)
J. Immunol. 178, 2737-2745
   Abstract »    Full Text »    PDF »
Persistent Antigen Presentation after Acute Vesicular Stomatitis Virus Infection.
D. L. Turner, L. S. Cauley, K. M. Khanna, and L. Lefrancois (2007)
J. Virol. 81, 2039-2046
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Rapid Clonal Expansion and Prolonged Maintenance of Memory CD8+ T Cells of the Effector (CD44highCD62Llow) and Central (CD44highCD62Lhigh) Phenotype by an Archaeosome Adjuvant Independent of TLR2.
L. Krishnan, K. Gurnani, C. J. Dicaire, H. van Faassen, A. Zafer, C. J. Kirschning, S. Sad, and G. D. Sprott (2007)
J. Immunol. 178, 2396-2406
   Abstract »    Full Text »    PDF »
An In Vivo Cytotoxicity Threshold for Influenza A Virus-Specific Effector and Memory CD8+ T Cells.
J. Stambas, P. C. Doherty, and S. J. Turner (2007)
J. Immunol. 178, 1285-1292
   Abstract »    Full Text »    PDF »
Combined TLR/CD40 Stimulation Mediates Potent Cellular Immunity by Regulating Dendritic Cell Expression of CD70 In Vivo.
P. J. Sanchez, J. A. McWilliams, C. Haluszczak, H. Yagita, and R. M. Kedl (2007)
J. Immunol. 178, 1564-1572
   Abstract »    Full Text »    PDF »
Protection against Vaccinia Virus Challenge by CD8 Memory T Cells Resolved by Molecular Mimicry.
M. Cornberg, B. S. Sheridan, F. M. Saccoccio, M. A. Brehm, and L. K. Selin (2007)
J. Virol. 81, 934-944
   Abstract »    Full Text »    PDF »
CD27low CD4 T Lymphocytes That Accumulate in the Mouse Lungs during Mycobacterial Infection Differentiate from CD27high Precursors In Situ, Produce IFN-{gamma}, and Protect the Host against Tuberculosis Infection.
M. A. Kapina, G. S. Shepelkova, V. V. Mischenko, P. Sayles, P. Bogacheva, G. Winslow, A. S. Apt, and I. V. Lyadova (2007)
J. Immunol. 178, 976-985
   Abstract »    Full Text »    PDF »
Human and Murine Obliterative Bronchiolitis in Transplant.
J. F. McDyer (2007)
Proceedings of the ATS 4, 37-43
   Abstract »    Full Text »    PDF »
Latent Virus Influences the Generation and Maintenance of CD8+ T Cell Memory.
B. S. Sheridan, K. M. Khanna, G. M. Frank, and R. L. Hendricks (2006)
J. Immunol. 177, 8356-8364
   Abstract »    Full Text »    PDF »
Control of Memory CD4 T Cell Recall by the CD28/B7 Costimulatory Pathway.
M. P. Ndejembi, J. R. Teijaro, D. S. Patke, A. W. Bingaman, M. R. Chandok, A. Azimzadeh, S. G. Nadler, and D. L. Farber (2006)
J. Immunol. 177, 7698-7706
   Abstract »    Full Text »    PDF »
Human Bone Marrow: A Reservoir for "Enhanced Effector Memory" CD8+ T Cells with Potent Recall Function.
X. Zhang, H. Dong, W. Lin, S. Voss, L. Hinkley, M. Westergren, G. Tian, D. Berry, D. Lewellen, R. G. Vile, et al. (2006)
J. Immunol. 177, 6730-6737
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CD8 T Cell Recall Responses Are Regulated by the Tissue Tropism of the Memory Cell and Pathogen.
K. D. Klonowski, A. L. Marzo, K. J. Williams, S.-J. Lee, Q.-M. Pham, and L. Lefrancois (2006)
J. Immunol. 177, 6738-6746
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Differential requirement for Lck during primary and memory CD8+ T cell responses.
K. Tewari, J. Walent, J. Svaren, R. Zamoyska, and M. Suresh (2006)
PNAS 103, 16388-16393
   Abstract »    Full Text »    PDF »
CD127+CCR5+CD38+++ CD4+ Th1 Effector Cells Are an Early Component of the Primary Immune Response to Vaccinia Virus and Precede Development of Interleukin-2+ Memory CD4+ T Cells..
J. J. Zaunders, W. B. Dyer, M. L. Munier, S. Ip, J. Liu, E. Amyes, W. Rawlinson, R. De Rose, S. J. Kent, J. S. Sullivan, et al. (2006)
J. Virol. 80, 10151-10161
   Abstract »    Full Text »    PDF »


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